Collagencin, an antibacterial peptide from fish collagen: Activity, structure and interaction dynamics with membrane

Ennaas, Nadia; Hammami, Riadh; Gomaa, Ahmed; Bédard, François; Biron, Éric; Subirade, Muriel; Beaulieu, Lucie; Fliss, Ismaı̈l

doi:10.1016/j.bbrc.2016.03.121

Cited by 92 publications

(56 citation statements)

References 18 publications

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“…Compared with marine collagen, MCPs have lower molecular weights resulting in easily being absorbed and strong affinities for water [18]. Due to the special marine ecological environment, such as high pressure, low temperature and high salinity, MCPs from marine fishes differ greatly from those from terrestrial livestock in both physicochemical properties and amino acid compositions, and have unique physiological functions including antibacterial [19], antioxidant [16,20], antihypertensive [21,22,23], neuroprotective [24] and anti-skin-aging activities [25]. It was reported that oral administration of marine collagen peptides from Chum Salmon ( Oncorhynchus keta ) skin enhanced cutaneous wound healing and angiogenesis in rats [26].…”

Section: Introductionmentioning

confidence: 99%

Marine Collagen Peptides from the Skin of Nile Tilapia (Oreochromis niloticus): Characterization and Wound Healing Evaluation

et al. 2017

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Burns can cause tremendous economic problems associated with irreparable harm to patients and their families. To characterize marine collagen peptides (MCPs) from the skin of Nile tilapia (Oreochromis niloticus), molecular weight distribution and amino acid composition of MCPs were determined, and Fourier transform infrared spectroscopy (FTIR) was used to analyze the chemical structure. Meanwhile, to evaluate the wound healing activity, in vitro and in vivo experiments were carried out. The results showed that MCPs prepared from the skin of Nile tilapia by composite enzymatic hydrolysis were composed of polypeptides with different molecular weights and the contents of polypeptides with molecular weights of less than 5 kDa accounted for 99.14%. From the amino acid composition, the majority of residues, accounting for over 58% of the total residues in MCPs, were hydrophilic. FTIR indicated that the main molecular conformations inside MCPs were random coil. In vitro scratch assay showed that there were significant effects on the scratch closure by the treatment of MCPs with the concentration of 50.0 μg/mL. In the experiments of deep partial-thickness scald wound in rabbits, MCPs could enhance the process of wound healing. Therefore, MCPs from the skin of Nile tilapia (O. niloticus) have promising applications in wound care.

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Section: Introductionmentioning

confidence: 99%

Marine Collagen Peptides from the Skin of Nile Tilapia (Oreochromis niloticus): Characterization and Wound Healing Evaluation

et al. 2017

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“…Available literature suggested that different nutritional properties of fish protein hydrolysates were related to their amino acids content (Abdelhedi et al., ). Fish protein hydrolysates for peptides generation have been reported (Ennaas et al., ). To accomplish this with much lower cost and workload, the virtual screening of ACE inhibitory peptides from Oncorhynchus mykiss nebulin was performed using in silico techniques and molecular docking program to simulate binding mechanism between ACE and the peptides.…”

Section: Introductionmentioning

confidence: 99%

Novel Angiotensin‐Converting Enzyme Inhibitory Peptides Derived from Oncorhynchus mykiss Nebulin: Virtual Screening and In Silico Molecular Docking Study

Yang

Zhao

et al. 2018

Journal of Food Science

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“…The industrial use of collagen has been limited to porcine skin and bovine skin and bone (Badii and Howell, 2006;Larrazábal and Camacho, 2008). However, the bovine spongiform encephalopathy (mad-cow disease) and foot-and-mouth disease (FMD) crisis as well as religious and social issues in some countries and markets and ecological impact of wasting the fish skin are the driving force for the increasing commercial use of fish collagen (Badii and Howell, 2006;Blanco et al, 2017;Ennaas et al, 2016;Gilsenan and Ross-Murphy, 2000;Karim and Bhat, 2009;Kim and Mendis, 2006;Rustad, 2003;Supavititpatana et al, 2008;Wasswa, et al, 2007). This approach assures the sustainable exploitation of marine resources whilst addressing the waste disposal issues related to environmental pollution (Carvalho et al, 2018).…”

Section: Collagen and Gelatinmentioning

confidence: 99%

Utilization of marine by-products for the recovery of value-added products

Shahidi¹,

Varatharajan²,

Han³

et al. 2019

JFB

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The world fisheries resources have exceeded 160 million tons in recent years. However, every year a considerable amount of total catch is discarded as by-catch or as processing leftovers, and that includes trimmings, fins, frames, heads, skin, viscera and among others. In addition, a large quantity of processing by-products is accumulated as shells of crustaceans and shellfish from marine bioprocessing plants. Recognition of the limited marine resources and the increasing environmental pollution has emphasized the need for better utilization of the by-products. Marine by-products contain valuable protein and lipid fractions, minerals, enzymes as well as many other components. The major fraction of by-products are used for feed production-in making fish meal/oil, but this has low profitability. However, there are many ways in which the fish and shellfish waste could be better utilized, including the production of novel food ingredients, nutraceuticals, pharmaceuticals, biomedical materials, fine chemicals, and other value-added products. In recent times, much research is conducted in order to explore the possible uses of different by-products. This contribution primarily covers the characteristics and utilization of the main ingredients such as protein, lipid, chitin and its derivatives, enzymes, carotenoids, and minerals originating from marine by-products.

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Collagencin, an antibacterial peptide from fish collagen: Activity, structure and interaction dynamics with membrane

Cited by 92 publications

References 18 publications

Marine Collagen Peptides from the Skin of Nile Tilapia (Oreochromis niloticus): Characterization and Wound Healing Evaluation

Marine Collagen Peptides from the Skin of Nile Tilapia (Oreochromis niloticus): Characterization and Wound Healing Evaluation

Novel Angiotensin‐Converting Enzyme Inhibitory Peptides Derived from Oncorhynchus mykiss Nebulin: Virtual Screening and In Silico Molecular Docking Study

Utilization of marine by-products for the recovery of value-added products

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