Collagenase-3 (MMP-13) Expression in Cutaneous Malignant Melanoma

Corte, M.D.; González, Luis O.; Corte, M.G.; Quintela, I; Pidal, Iván; Bongera, Miguel; Vizoso, F

doi:10.1177/172460080502000407

Cited by 34 publications

(27 citation statements)

References 40 publications

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“…However, it may also act as a potent gelatinase by degrading a wide variety of extracellular matrix components (30,31). MMP-13 is overexpressed in a variety of tumors from such as head and neck, laryngeal, breast, chondrosarcoma, gastric, colorectal, vulvar carcinomas and cutaneous malignant lymphoma (17,(32)(33)(34)(35)(36)(37)(38)(39).…”

Section: Discussionmentioning

confidence: 99%

Matrix Metalloproteinase-13 (MMP-13) Directly and Indirectly Promotes Tumor Angiogenesis

Kudo

Iizuka

Yoshida

et al. 2012

Journal of Biological Chemistry

119

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Background:Angiogenesis is an important step in the metastatic cascade of tumors. Results: MMP-13 itself as well as VEGF-A secretion from fibroblasts promotes angiogenesis. Indeed, MMP-13 is well correlated with blood vessel density in human cancer tissues. Conclusion: MMP-13 can be a marker for prediction of malignant behaviors and a therapeutic target in cancer. Significance: This work provides new insights regarding the role of MMP-13 in tumor angiogenesis.

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Section: Discussionmentioning

confidence: 99%

Matrix Metalloproteinase-13 (MMP-13) Directly and Indirectly Promotes Tumor Angiogenesis

Kudo

Iizuka

Yoshida

et al. 2012

Journal of Biological Chemistry

119

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“…12,16 MMP13 seems to be related to an aggressive phenotype of melanoma. 17,18 In contrast to MMP2, MMP9 and MMP21 seem to have a more essential function in early events of melanoma formation and are downregulated in invasive stages. 18,19 In parallel to extracellular matrix degradation, adhesive characteristic of tumour cells during melanoma progression is changing.…”

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confidence: 99%

MMP19 is upregulated during melanoma progression and increases invasion of melanoma cells

Müller

Beck

Gadesmann³

et al. 2010

Modern Pathology

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During the progression of cutaneous melanomas, matrix metalloproteinases (MMPs) facilitate the tumour cells to traverse the basement membrane and invade the dermis. In this study, we analysed the expression of MMP19 in the course of melanoma progression. Although MMP19 was absent in melanocytes and melanoma cells of early stages of melanoma development, its expression was strongly upregulated in the neighbouring keratinocytes that may facilitate the vertical outgrowth of melanoma cells. In contrast to early stages, MMP19 was upregulated during the vertical growth phase of melanoma and in metastases. The upregulation of MMP19 in melanoma of Clark levels IV and V correlates with that of MMP2 and also simultaneously with ceased expression of E-cadherin. To reveal whether MMP19 facilitates the invasion of melanomas, we examined adhesion and migratory capacity of selected melanoma cell lines. Melanoma cell lines with low expression of MMP19 exhibited increased adhesion to various substrates and lower migration in comparison with the cell line with higher expression of MMP19. Moreover, ectopic expression of MMP19 could restore the migratory capacity of melanoma cells with low endogenous level of MMP19. These results suggest that the increase of MMP19 expression hallmarks the progression of cutaneous melanoma and might augment melanoma growth by promoting the invasion of tumour cells.

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“…Compared to patients with negative-to-moderate MMP2 expression, patients with high MMP2 levels have significantly lower survival rates, and this information could predict patient survival, independent of tumor thickness and ulceration (48). Other studies have shown that higher MMP13 expression, which belongs to the collagenase group, is notably associated with metastasis and poorer survival of melanoma patients (26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

“…Although MMP13 is also gelatinolytic and type IV collagenolytic, it is prone to degrading type I, II and III collagens (25). Previous studies have shown that upregulated MMP13 and its activity in melanoma cell lines are involved in the metastasis of melanoma (26,27). A recent study revealed that MMP13 not only cleaves laminin-5 into small fragments to accelerate tumor metastasis but also disrupts vasculogenic mimicry in the presence of cleaved laminin-5, exerting dual effects on melanoma (28).…”

Section: Introductionmentioning

confidence: 99%

Lentiviral-mediated overexpression of long non-coding RNA GAS5 reduces invasion by mediating MMP2 expression and activity in human melanoma cells

Chen

Yang

et al. 2016

International Journal of Oncology

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Abstract. The present study evaluated the effects of long non-coding RNA GAS5 on the migration and invasion of melanoma cells. Using the SK-Mel-110 melanoma cell line, we stably expressed GAS5, visualized the distribution of GAS5 by RNA fluorescence in situ hybridization (FISH) and examined changes in cell migration and invasion with Transwell assays. In GAS5 overexpressed SK-Mel-110 cells, migrated and invaded cells decreased by 65.3 and 55.6%, respectively. Moreover, the MMP2 protein level, and its activity was downregulated by 67.9 and 15.8%, respectively. Overexpressing lncRNA GAS5 inhibited the migration and invasion ability of melanoma SK-Mel-110 cells, partially by decreasing the MMP2 expression and its activity. This study is the first to reveal a potential relationship between lncRNA GAS5 and the migration and invasion of melanoma.

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Collagenase-3 (MMP-13) Expression in Cutaneous Malignant Melanoma

Abstract: MMP-13 appears to be a factor associated with tumor aggressiveness in CMM. It seems to eliminate an important barrier not only against tumoral invasion but also against proliferation.

Cited by 34 publications

References 40 publications

Matrix Metalloproteinase-13 (MMP-13) Directly and Indirectly Promotes Tumor Angiogenesis

Matrix Metalloproteinase-13 (MMP-13) Directly and Indirectly Promotes Tumor Angiogenesis

MMP19 is upregulated during melanoma progression and increases invasion of melanoma cells

Lentiviral-mediated overexpression of long non-coding RNA GAS5 reduces invasion by mediating MMP2 expression and activity in human melanoma cells

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