Collagen type in dysfunctional temporomandibular joint disks

Gage, J. P.; Shaw, Robin M.; Moloney, Frank

doi:10.1016/s0022-3913(05)80355-5

Cited by 33 publications

(27 citation statements)

References 20 publications

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“…40 These fibers are roughly parallel, with considerable crimping and branching observed in the intermediate zone. 28 Elastin fibers can also be found in the TMJ disc; however, these fibers are found in much smaller amounts relative to collagen. The elastin content of the bovine TMJ disc was found to be in the range of 3-7% of the total mass; 42 in the human disc, elastin content has been reported to make up 0.339% of the total volume.…”

Section: Collagen and Elastin Fibersmentioning

confidence: 99%

“…Collagen fibers construct the vast majority of the TMJ disc's ECM architecture. Approximately 30% of the wet weight, 28 83-96% of the dry ALLEN AND ATHANASIOU weight, 29,30 and 50% of the volume 12,31 of the TMJ disc are occupied by collagen. Collagen fibers form a ringlike alignment around the periphery of the TMJ disc and a strong anteroposterior alignment through the central regions.…”

Section: Collagen and Elastin Fibersmentioning

confidence: 99%

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Tissue Engineering of the TMJ Disc: A Review

Allen

Athanasiou

2006

Tissue Engineering

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The potential impact of a tissue-engineered temporomandibular joint (TMJ) disc is immense. Currently, patients suffering from a severely dysfunctional TMJ have few options. Facing the general lack of safe, effective TMJ disc implants, many patients undergo discectomy, a procedure that removes the injured TMJ disc in hopes of reducing debilitating symptoms associated with severe TMJ disorders. This procedure may not be ideal as the TMJ is left without an important functional component. Tissue engineering is a promising approach for the creation of viable, effective implants. The first attempt to investigate TMJ disc cells on a biomaterial was conducted in 1991. The first TMJ tissue-engineered constructs to be tested biochemically and biomechanically were formed in 1994; however, in examining this study in retrospect, it is clear how little TMJ knowledge was available at that time. Within the last 10 to 15 years, multiple studies have investigated critical TMJ disc characteristics, and while this characterization is not complete, these data have created a solid foundation for tissue-engineering research. Thus, the last 5 years have yielded core studies investigating the principal elements of tissue engineering: scaffold, cell source, and biological/biomechanical stimuli. Although TMJ disc tissue engineering is still in its formative years, its future is quite promising. Key studies are now being conducted that will assist in the establishment of a solid TMJ disc tissue-engineering approach. As the challenges of tissue engineering are faced and met, the ultimate goal of creating a functional biological implant nears.

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Section: Collagen and Elastin Fibersmentioning

confidence: 99%

Section: Collagen and Elastin Fibersmentioning

confidence: 99%

Tissue Engineering of the TMJ Disc: A Review

Allen

Athanasiou

2006

Tissue Engineering

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“…In EDS dermatosparaxis type different orofacial structures primarily consisting of type Tcollagen, such as the craniofacial skeleton, mucosa, teeth and temporomandibular joints [Gage et al, 1995], may be affected. Evidence of dentin defects, presenting with opalescent discoloration, pre-and post-eruptive pulp calcification and dysplastic roots, may be seen in some permanent teeth.…”

Section: Fig 4 Illustration Of Facial Resemblance Between Patients mentioning

confidence: 99%

The natural history, including orofacial features of three patients with Ehlers–Danlos syndrome, dermatosparaxis type (EDS type VIIC)

Malfait

Coster

Haußer

et al. 2004

American J of Med Genetics Pt A

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Ehlers-Danlos syndrome (EDS) dermatosparaxis type (type VIIC) and the related disease of cattle dermatosparaxis, are recessively inherited connective tissue disorders, caused by a deficient activity of procollagen I N-proteinase, the enzyme that excises the N-terminal propeptide in procollagen type I, type II, and type III. Although well documented in cattle, to date only seven human cases have been recorded, most of them aged under 2 years. We document the natural history of three patients with EDS dermatosparaxis type, two of whom have been reported before the age of 2 years, and one new patient. The phenotype of the patients, and especially the facial resemblance, is striking, making this a clinically recognizable condition. The most consistent anomalies during the first years of life are premature rupture of the membranes, extreme skin fragility and easy bruising, large fontanels, blue sclerae, puffy eyelids, micrognathia, umbilical hernia, and short fingers. Joint hypermobility becomes more important with age. The children are at risk for rupture of internal organs due to soft tissue fragility, as is illustrated by different internal events in two of the three patients described here. Orofacial features include micrognathia, a frontal open bite, and gingival hyperplasia with varying degrees of hyperkeratosis. The deciduous dentition shows abnormal morphology of the molars, obliteration of the tooth pulp, and severe enamel attrition. The permanent dentition shows agenesis and microdontia of several teeth. Tooth discoloration, dysplastic roots, and tooth pulp obliteration are present in a restricted number of permanent teeth.

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“…1 Reports in the literature are scarce and not always consistent. Collagen content has been reported to be 58% by volume, 10 or about 37% by wet weight, 23 or 68% 3 to 83% 38 by dry weight. It has been well established in the literature that type I collagen is the most abundant collagen type found in the TMJ disc by far.…”

Section: Introductionmentioning

confidence: 99%

Effects of Initial Cell Seeding Density for the Tissue Engineering of the Temporomandibular Joint Disc

Almarza

Athanasiou

2005

Ann Biomed Eng

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Tissue engineering may provide a better treatment modality for postoperative discectomy patients. The TMJ disc is an ideal candidate for tissue engineering approaches because of its lack of an intrinsic regenerative ability. Unfortunately, basic knowledge related to TMJ disc tissue engineering is still at an infancy level and not on par to that related to articular cartilage tissue engineering. The objective of this study was to examine the effects of initial cell density of TMJ disc cells seeded in nonwoven poly-glycolic acid (PGA) scaffolds on the biochemical and biomechanical properties of constructs examined at 0, 3, and 6 weeks after seeding. Low, medium, and high seeding densities were chosen to be 15, 30, and 120 million cells per ml of scaffold, which were seeded using a spinner flask. Significant differences were found temporally and as a function of seeding density in morphology, total collagen, GAG content, and permeability of the constructs, but not in aggregate modulus. The high seeding density group outperformed the low and medium groups in collagen and GAG content at all time points measured. The high-density group produced a total of 55.37 +/- 3.56 microg of collagen per construct, maintained 15.77 +/- 1.86 microg of GAG per construct, and only shrunk to 50% of the original scaffold size. Permeability of the constructs at 6 weeks was decreased by 70% compared to 0 weeks.

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Collagen type in dysfunctional temporomandibular joint disks

Cited by 33 publications

References 20 publications

Tissue Engineering of the TMJ Disc: A Review

Tissue Engineering of the TMJ Disc: A Review

The natural history, including orofacial features of three patients with Ehlers–Danlos syndrome, dermatosparaxis type (EDS type VIIC)

Effects of Initial Cell Seeding Density for the Tissue Engineering of the Temporomandibular Joint Disc

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