1993
DOI: 10.1006/exer.1993.1070
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Collagen Type I mRNA Levels in Cultured Human Lamina Cribrosa Cells: Effects of Elevated Hydrostatic Pressure

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Cited by 42 publications
(27 citation statements)
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“…As we will demonstrate in subsequent sections, there is overlap between the pressure-induced phenotype and glaucomatous cellular profiles that have been described previously (Hernandez et al, 2002;Nickells, 2007). Similarly, we found that extended HP treatment of ONH astrocytes (72-120 hr) induces further changes in cellular phenotype with respect to the expression of genes that affect cell motility (Miao et al, 2010) and cell morphology (Yang et al, 1993). …”
Section: Microarray Data Analysissupporting
confidence: 84%
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“…As we will demonstrate in subsequent sections, there is overlap between the pressure-induced phenotype and glaucomatous cellular profiles that have been described previously (Hernandez et al, 2002;Nickells, 2007). Similarly, we found that extended HP treatment of ONH astrocytes (72-120 hr) induces further changes in cellular phenotype with respect to the expression of genes that affect cell motility (Miao et al, 2010) and cell morphology (Yang et al, 1993). …”
Section: Microarray Data Analysissupporting
confidence: 84%
“…Cluster 3 genes are found in pathways leading to cytoskeleton remodeling, transport, and other signaling processes. ONH astrocytes undergo changes in morphology after being subjected to elevated HP (Yang et al, 1993) and up-regulation of cytoskeletal signaling processes is consistent with these properties. Moreover, altered cytoskeletal , transport, and cell adhesion gene expression is also found in populations of glaucomatous astrocytes .…”
Section: Hp-induced Cellular Processes In Onh Astrocytessupporting
confidence: 60%
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“…192,196,197 The increased interstitial hydrostatic pressure can, in turn, influence the function of the resident cells and the composition of ECM itself. In vitro studies have shown that exposure to elevated hydrostatic pressure increased production of collagen type I and aggrecan, 198 decreased MMP2 and MMP3 expression, 199,200 decreased collagen I, and increased sulfated glycosaminoglycans production. 201 These changes further alter ECM composition influencing intercellular transportation.…”
Section: Matrix As a Hydrostatic Environmentmentioning
confidence: 99%
“…Concerning the study of glaucoma, EHP has been used to mimic ocular hypertension. Several studies have reported the effect of EHP on cells of the trabecular meshwork [18][19][20] and Schlemm's canal [21] and other cell types [22] . The mechanisms whereby retinal cells sense mechanical pressure have not yet been completely elucidated, yet some possibilities have been considered [for a review, see 23 ].…”
Section: Advantages Of Using In Vitro Models To Study Glaucomamentioning
confidence: 99%