Collagen-Shield Delivery of Gentamicin and Vancomycin

Phinney, Richard B.

doi:10.1001/archopht.1988.01060140767052

Cited by 100 publications

(30 citation statements)

References 26 publications

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“…In addition to the soft hydrogel lens and their derivatives, collagen shields have also proven to be effective delivery modalities. The collagen shield contact lens is a therapeutic lens composed of non-cross linked porcine collagen with the capability of dissolving on the corneal surface over a period of around 12 hours (Phinney et al, 1988). Studies done using collagen shields soaked with gentamicin and vancomycin produced tear, cornea, and aqueous humor levels that were generally higher or comparable to those achieved through frequent drop administrations (Phinney et al, 1988).…”

Section: Ocular Surface Prosthetic Devicessupporting

confidence: 39%

“…The collagen shield contact lens is a therapeutic lens composed of non-cross linked porcine collagen with the capability of dissolving on the corneal surface over a period of around 12 hours (Phinney et al, 1988). Studies done using collagen shields soaked with gentamicin and vancomycin produced tear, cornea, and aqueous humor levels that were generally higher or comparable to those achieved through frequent drop administrations (Phinney et al, 1988). Further, collagen shields used for heparin delivery in postoperative rabbit eyes helped to prevent postoperative fibrin formation in eyes at risk for this complication (i.e.…”

Section: Ocular Surface Prosthetic Devicesmentioning

confidence: 44%

See 1 more Smart Citation

Ocular Surface Reconstitution

Nguyẽ̂n¹,

Khashabi²,

Yiu³

2011

Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications

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Section: Ocular Surface Prosthetic Devicessupporting

confidence: 39%

Section: Ocular Surface Prosthetic Devicesmentioning

confidence: 44%

Ocular Surface Reconstitution

Nguyẽ̂n¹,

Khashabi²,

Yiu³

2011

Progress in Molecular and Environmental Bioengineering - From Analysis and Modeling to Technology Applications

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“…Pumps can deliver fluid to the eye for extended periods of time via a tube with its distal opening into the congjunctival sac, anterior chamber or vitreous cavity. Collagen shields have been used to deliver drugs and promote epithelial healing [2,3]. For example, postoperative antibiotics can be delivered by a pre-soaked collagen shield applied at the completion of cataract or corneal surgery.…”

supporting

confidence: 39%

Antibiotic-Impregnated Fibrin Glue in Ocular Surgery:In vitro Antibacterial Activity

Marone¹,

Monzillo

Segú³

et al. 1998

Ophthalmologica

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A strategy to reduce postoperative ocular infections might consist in maintaining a high antibiotic concentration in the eye by using a topical slow-release drug formulation. Fibrin glue is widely used in ocular surgery. Vancomycin, teicoplanin, cephalothin and gentamicin were added to a 500 IU/ml thrombin solution, their concentrations in 1 g fibrin glue being 500 µg for vancomycin and 400 µg for the other drugs. The in vitro antibacterial activity of antibiotic-impregnated fibrin glue was evaluated against a recent clinical isolate of Staphylococcus epidermidis. Moreover the antibiotic elution from fibrin discs in saline was assayed for up to 96 h. Fibrin glue properties were maintained when thrombin was reconstituted with a CaCl₂ solution additioned with the antibiotics tested. All antibiotic fibrin mixtures exhibited good antistaphylococcal activity immediately after the preparation. A prolonged inhibition (4 days) of S. epidermidis growth was observed with teicoplanin discs. Gentamicin and teicoplanin levels were higher than those of the other antibiotics. The results suggest that the fibrin glycopeptide and/or gentamicin mixtures can be used, both prophylactically and therapeutically, in ocular surgery.

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“…77 It is worth mentioning that type I collagen is also com mercially available and used as wound dressing, especially in the case of burns, 83,84 as a main component of many creams designed for care or treatment of skin laxity, rhytides, or photoaging, 85 or as a component of many engineered materi als used for bone regeneration and cancer treatment. 70,78,86,87 Collagen has also been used since 1980 as a drugdelivery system for ophthalmic agents (especially the antibiotics gentamicin and vancomycin), 88 the trend being to extend the use of this material in obtaining many other drugdelivery systems. 71,78,89 Despite intensive research efforts in the field of bone and bone grafts, 29,[90][91][92][93][94] the properties of the materials obtained are still far from those of healthy bone.…”

Section: Collagen-hydroxyapatite Composite Materialsmentioning

confidence: 41%

Multifunctional materials for bone cancer treatment

Marques¹,

Ferreira²,

Andronescu³

et al. 2014

IJN

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The purpose of this review is to present the most recent findings in bone tissue engineering. Special attention is given to multifunctional materials based on collagen and collagen–hydroxyapatite composites used for skin and bone cancer treatments. The multi-functionality of these materials was obtained by adding to the base regenerative grafts proper components, such as ferrites (magnetite being the most important representative), cytostatics (cisplatin, carboplatin, vincristine, methotrexate, paclitaxel, doxorubicin), silver nanoparticles, antibiotics (anthracyclines, geldanamycin), and/or analgesics (ibuprofen, fentanyl). The suitability of complex systems for the intended applications was systematically analyzed. The developmental possibilities of multifunctional materials with regenerative and curative roles (antitumoral as well as pain management) in the field of skin and bone cancer treatment are discussed. It is worth mentioning that better materials are likely to be developed by combining conventional and unconventional experimental strategies.

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Collagen-Shield Delivery of Gentamicin and Vancomycin

Cited by 100 publications

References 26 publications

Ocular Surface Reconstitution

Ocular Surface Reconstitution

Antibiotic-Impregnated Fibrin Glue in Ocular Surgery:In vitro Antibacterial Activity

Multifunctional materials for bone cancer treatment

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