Collagen-protein-polysaccharide interactions in human intervertebral disc

Steven, F. S.; Knott, Jeff; Jackson, David S.; Podrazký, V.

doi:10.1016/0005-2795(69)90080-4

Cited by 25 publications

(10 citation statements)

References 14 publications

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“…Therefore, our data are in agreement with those of Steven et al (14), Mathews (IS), and Mashburn and Hoffman ( 1 7 ) in that there are both ionic and covalent bonds between collagen and acid mucopolysaccharide. Under our electrophoretic conditions, the separation of the toluidine blue positive acid mucopolysaccharides from the proteins indicated that the bonds between the acid mucopolysaccharides and the proteins are due to ionic interactions in most of the fractions that we obtained (ie., Al, A2, A3, T1, TZ, and R ) exceptions being T3 and Tq.…”

supporting

confidence: 93%

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Studies on the Insoluble Residue of Human Costal Cartilage

Kao

Leslie

Hitt

1971

Experimental Biology and Medicine

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supporting

confidence: 93%

“…(12)(13)(14) extracted and fractionated the proteins from human articular, costal, and intervertebral cartilages. Recently, Steven et at?.…”

mentioning

confidence: 99%

Studies on the Insoluble Residue of Human Costal Cartilage

Kao

Leslie

Hitt

1971

Experimental Biology and Medicine

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“…There is now an overwhelming body of evidence (191,201,202,205,206,311) to support the view originally proposed by Meyer (215) that the long-chain matrix polymers with their regular anionic spacings provide the essential molecular template for the precise orderly deposition of collagen precursors and their regular sequential arrangement into collagen fibrils. Thus, enzymatic dissolution of the matrix would also inhibit new collagen formation.…”

Section: March 1979mentioning

confidence: 78%

“…More specifically, electron microscopy show a precise molecular alignment of proteoglycans along collagen chains (191). Ionic interactions between positively charged lysine and arginine residues of polymeric collagen and negatively charged glycosaminoglycan and proteoglycan sulfonic acid groups, together with the formation of hydrogen bonds, offer a probable explanation for this "adhesiveness" (311). The enzymatic degradation of such vital cross-linking bonds in the immediate vicinity of neoplastic cells could result in the dissolution and "microscopic disappearance" of this essential molecular scaffolding.…”

Section: March 1979mentioning

confidence: 99%

Orthomolecular Medicine

McLeay¹

2001

World Scientific Series in 20th Century Chemistry

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“…Ascorbate deficiency significantly reduces hydroxylation of proline and lysine to hydroxyproline and hydroxylysine respectively, thereby interfering with the required collagen cross-linking. Additionally the strength of the intercellular matrix also depends upon the abundance of certain long-chain mucopolysaccharide polymers, the glycosaminoglycans and proteoglycans [117,118]. Normally the intercellular matrix is maintained in steady-state equilibrium with the homeostatic balance between the formation of new macromolecules (polymerization) and decay (depolymerization) of the pre-existing ones.…”

Section: Stabilization Of Intercellular Matrix and "Walling Off" Effectmentioning

confidence: 99%

Ascorbic Acid in Cancer Chemoprevention: Translational Perspectives and Efficacy

Ullah¹,

Bhat²,

Hussain³

et al. 2012

CDT

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Chemoprevention, which is referred to as the use of nontoxic natural or synthetic chemicals to intervene in multistage carcinogenesis has since decades attracted a considerable interest in plant-derived chemical constituents often termed as "phytochemicals" or sometimes as "Nutraceuticals" in case they are derived from dietary sources. A comprehensive search of the literature show that such an interest in natural product pharmacology has surged in the last 25 years and particularly risen at exponential rates since the last one decade. Phytochemicals such as curcumin (from spice turmeric), resveratrol (from red wine) and genistein (from soy) share the major efforts as indicated by overwhelming publications, despite skepticism concerning their bioavailability. Ascorbic acid (AA), the popular anti-oxidant in fruits and vegetables, has even a longer historical perspective than these dietary agents as for more than 35 years; there had been lingering questions about the efficacy of AA in cancer therapy. The footprints of AA from "scurvy" to "cancer" though complex seems to carry potential provided the puzzle could be set right. The use of AA in cancer treatment has been debated extensively as evident from the literature but surprisingly the complementing early phase bench work on the mechanistic studies for anticancer action was rather retarded. Proposed mechanisms of action for AA in the prevention and treatment of cancer includes antioxidant as well as pro-oxidant properties, stimulation of the immune system, altering carcinogen metabolism, enhancement of collagen synthesis necessary for tumor encapsulation and interference with cancer cell signaling. The observation that the intravenous administration of AA enhances its bioavailability to the extent of deriving pharmacological benefits against cancer has in recent years partially supported the clinical plausibility (efficacy) of AA towards realizing its translational advantage. Here, we provide an overview of AA with regard to its potential in the management of cancer disease.

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Collagen-protein-polysaccharide interactions in human intervertebral disc

Cited by 25 publications

References 14 publications

Studies on the Insoluble Residue of Human Costal Cartilage

Studies on the Insoluble Residue of Human Costal Cartilage

Orthomolecular Medicine

Ascorbic Acid in Cancer Chemoprevention: Translational Perspectives and Efficacy

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