Collagen: New Dimension in Cosmetic and Healthcare

Samad, Nur Amirah Abd; Sikarwar, Archana Singh

doi:10.9734/ijbcrr/2016/27271

Cited by 17 publications

(15 citation statements)

References 27 publications

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“…Collagen molecules exist in a triple helix structure in which three primary protein strands are twisted, and the amino acid sequence of the collagen protein is typically glycine-proline-X or glycine-X-hydroxyproline, where X may be any amino acid other than glycine, proline, or hydroxyproline [ 10 , 11 ]. Twenty-eight types of collagen proteins are known so far, and there are some differences in amino acid composition and sequence [ 12 , 13 ]. Transforming growth factor (TGF)-β1 plays an important and diverse role in the synthesis of collagen [ 14 ], and the degradation of collagen is mediated by matrix metalloproteinases (MMPs) [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Ascorbic Acid (Vitamin C) as a Cosmeceutical to Increase Dermal Collagen for Skin Antiaging Purposes: Emerging Combination Therapies

Boo

2022

Antioxidants

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Ascorbic acid (AA) is an essential nutrient and has great potential as a cosmeceutical that protects the health and beauty of the skin. AA is expected to attenuate photoaging and the natural aging of the skin by reducing oxidative stress caused by external and internal factors and by promoting collagen gene expression and maturation. In this review, the biochemical basis of AA associated with collagen metabolism and clinical evidence of AA in increasing dermal collagen and inhibiting skin aging were discussed. In addition, we reviewed emerging strategies that have been developed to overcome the shortcomings of AA as a cosmeceutical and achieve maximum efficacy. Because extracellular matrix proteins, such as collagen, have unique amino acid compositions, their production in cells is influenced by the availability of specific amino acids. For example, glycine residues occupy 1/3 of amino acid residues in collagen protein, and the supply of glycine can be a limiting factor for collagen synthesis. Experiments showed that glycinamide was the most effective among the various amino acids and amidated amino acids in stimulating collagen production in human dermal fibroblasts. Thus, it is possible to synergistically improve collagen synthesis by combining AA analogs and amino acid analogs that act at different stages of the collagen production process. This combination therapy would be useful for skin antiaging that requires enhanced collagen production.

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Section: Introductionmentioning

confidence: 99%

Ascorbic Acid (Vitamin C) as a Cosmeceutical to Increase Dermal Collagen for Skin Antiaging Purposes: Emerging Combination Therapies

Boo

2022

Antioxidants

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“…During the first three weeks of exposure, the average TEWL values increased fivefold, then kept increasing over three weeks and then remained almost constant. The extreme increase in TEWL values is attributed to the fact that volunteers were in contact with heavy metals and chemicals at work [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

Collagen Hydrolysate Prepared from Chicken By-Product as a Functional Polymer in Cosmetic Formulation

et al. 2021

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Chicken stomachs can be processed into collagen hydrolysate usable in cosmetic products. The aim of the study was to verify the effects of a carbopol gel formulation enriched with 1.0% (w/w) chicken hydrolysate on the properties of the skin in the periorbital area after regular application twice a day for eight weeks in volunteers ageed 50 ± 9 years. Skin hydration, transepidermal water loss (TEWL), skin elasticity and skin relief were evaluated. Overall, skin hydration increased by 11.82% and 9.45%, TEWL decreased by 25.70% and 17.80% (always reported for the right and left area). Generally, there was an increase in skin elasticity, a decrease in skin roughness, as the resonance times decreased by 85%. The average reduction of wrinkles was 35.40% on the right and 41.20% on the left. For all results, it can be seen that the longer the cosmetic gel formulation is applied, the better the results. Due to the positive effect on the quality and functionality of the skin, it is possible to apply the cosmetic gel formulation in the periorbital area. The advantage of the product with chicken collagen hydrolysate is also the biocompatibility with the skin and the biodegradability of the formulation.

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“… 1 Fibril-Associated Collagens with Interrupted Triple-helices, 2 Membrane-Associated Collagens with Interrupted Triple-helices, 3 Multiple triple-helix domains and interruptions [ 21 , 22 , 23 , 24 , 25 , 26 ]. …”

Section: Figurementioning

confidence: 99%

Collagen Alignment via Electro-Compaction for Biofabrication Applications: A Review

Carr

Chen²,

Chung³

et al. 2022

Polymers

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As the most prevalent structural protein in the extracellular matrix, collagen has been extensively investigated for biofabrication-based applications. However, its utilisation has been impeded due to a lack of sufficient mechanical toughness and the inability of the scaffold to mimic complex natural tissues. The anisotropic alignment of collagen fibres has been proven to be an effective method to enhance its overall mechanical properties and produce biomimetic scaffolds. This review introduces the complicated scenario of collagen structure, fibril arrangement, type, function, and in addition, distribution within the body for the enhancement of collagen-based scaffolds. We describe and compare existing approaches for the alignment of collagen with a sharper focus on electro-compaction. Additionally, various effective processes to further enhance electro-compacted collagen, such as crosslinking, the addition of filler materials, and post-alignment fabrication techniques, are discussed. Finally, current challenges and future directions for the electro-compaction of collagen are presented, providing guidance for the further development of collagenous scaffolds for bioengineering and nanotechnology.

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Collagen: New Dimension in Cosmetic and Healthcare

Cited by 17 publications

References 27 publications

Ascorbic Acid (Vitamin C) as a Cosmeceutical to Increase Dermal Collagen for Skin Antiaging Purposes: Emerging Combination Therapies

Ascorbic Acid (Vitamin C) as a Cosmeceutical to Increase Dermal Collagen for Skin Antiaging Purposes: Emerging Combination Therapies

Collagen Hydrolysate Prepared from Chicken By-Product as a Functional Polymer in Cosmetic Formulation

Collagen Alignment via Electro-Compaction for Biofabrication Applications: A Review

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