Collagen gel formation in the presence of a carbon nanobrush

Dombi, George W.; Purohit, Kaushalkumar; Martin, Lenore M.; Yang, Sze C.

doi:10.1007/s10856-014-5356-4

Cited by 8 publications

(6 citation statements)

References 37 publications

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“…Some managed to develop a platform of sustained release of nitric oxide, using nanoparticles, to achieve a reduction in inflammation, along with a marked increase in collagen deposition, accelerating wound healing (131). Other interesting designs have produced similar effects; carbon nanotube on polystyrene and polyaniline copolymer increased collagen gelation in a dose-dependent manner, whilst leaving D-periodicity and average fibril diameter of this immense protein, largely unchanged (132). An appreciation of the size of collagen molecules, along with the cross-linking required, results in more justice to the complexity of the process and the role of nanoparticles.…”

Section: Nanoparticles and Collagen Depositionmentioning

confidence: 99%

Nanoparticles in wound healing from hope to promise from promise to routine

Seifalian¹

2018

Front Biosci

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Chronic non-healing wounds represent a growing problem due to their high morbidity and cost. Despite recent advances in wound healing, several systemic and local factors can disrupt the weighed physiologic healing process. This paper critically reviews and discusses the role of nanotechnology in promoting the wound healing process. Nanotechnology-based materials have physicochemical, optical and biological properties unique from their bulk equivalent. These nanoparticles can be incorporated into scaffolds to create nanocomposite smart materials, which promote wound healing through their antimicrobial, as well as selective anti- and pro-inflammatory, and pro-angiogenic properties. Owed to their high surface area, nanoparticles have also been used for drug delivery as well as gene delivery vectors. In addition, nanoparticles affect wound healing by influencing collagen deposition and realignment and provide approaches for skin regeneration and wound healing.

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Section: Nanoparticles and Collagen Depositionmentioning

confidence: 99%

Nanoparticles in wound healing from hope to promise from promise to routine

Seifalian¹

2018

Front Biosci

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“…Fullerene itself acts as an antioxidant and prevents premature skin aging. [225][226][227][228][229] Fullerene delivers vitamins to effectively enhance the skin. Recently, some researchers developed a fullerene nanocapsule with ascorbic acid and vitamin E. It showed enhanced skin protective activity against premature aging by its antioxidant activities.…”

Section: Fullerenementioning

confidence: 99%

“…226,239,240 Recently, curcumin was conjugated to a single wall carbon nanotube for the effective delivery. 241 The role of hyaluronic acids in the delivery of drugs using carbon nanotubes was reviewed recently, 242 and further clinical trials are needed to assess their biosafety.…”

mentioning

confidence: 99%

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

Ganesan¹,

Choi²

2016

IJN

131

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Phytocompounds have been used in cosmeceuticals for decades and have shown potential for beauty applications, including sunscreen, moisturizing and antiaging, and skin-based therapy. The major concerns in the usage of phyto-based cosmeceuticals are lower penetration and high compound instability of various cosmetic products for sustained and enhanced compound delivery to the beauty-based skin therapy. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery of phyto-derived bioactive compounds in cosmeceutical sectors and products. Nanosizing of phytocompounds enhances the aseptic feel in various cosmeceutical products with sustained delivery and enhanced skin protecting activities. Solid lipid nanoparticles, transfersomes, ethosomes, nanostructured lipid carriers, fullerenes, and carbon nanotubes are some of the emerging nanotechnologies currently in use for their enhanced delivery of phytocompounds in skin care. Aloe vera , curcumin, resveratrol, quercetin, vitamins C and E, genistein, and green tea catechins were successfully nanosized using various delivery technologies and incorporated in various gels, lotions, and creams for skin, lip, and hair care for their sustained effects. However, certain delivery agents such as carbon nanotubes need to be studied for their roles in toxicity. This review broadly focuses on the usage of phytocompounds in various cosmeceutical products, nanodelivery technologies used in the delivery of phytocompounds to various cosmeceuticals, and various nanosized phytocompounds used in the development of novel nanocosmeceuticals to enhance skin-based therapy.

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“…bones, tendons, lungs, and skin. Additionally, the proteins ability to improve the cells adhesion and promote the production of ECM from proliferating cells is the reason that collagen and elastin are attractive for biomaterials technology and tissue engineering . However, their use, particularly the elastin, is limited because of the purification procedures.…”

Section: Introductionmentioning

confidence: 99%

PEG-dialdehyde-the new cross-linking agent for collagen/elastin hydrogels

Skopińska-Wiśniewska

Bajek

Maj

et al. 2016

Polym. Adv. Technol.

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Collagen and elastin are the major proteins of an extracellular matrix. They possess attractive, complementary mechanical properties in their native state, but during isolation, its unique structure is destroyed, which affects the parameters of the materials. However, they still have excellent biological properties. The cross-linking process improves the physicochemical properties of protein materials. The ideal cross-linking agent should be effective and does not impair the biological properties of the material. Therefore, poly(ethylene) glycol-dialdehyde was used in the study. The results show that the addition of poly(ethylene) glycol-dialdehyde in combination with the neutralization of a collagen/elastin solution is a useful method for preparation of protein hydrogels. The gels are transparent and relatively stiff. They exhibit good mechanical properties, surface properties and are attractive for 3 T3 cells.

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Collagen gel formation in the presence of a carbon nanobrush

Cited by 8 publications

References 37 publications

Nanoparticles in wound healing from hope to promise from promise to routine

Nanoparticles in wound healing from hope to promise from promise to routine

Current application of phytocompound-based nanocosmeceuticals for beauty and skin therapy

PEG-dialdehyde-the new cross-linking agent for collagen/elastin hydrogels

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