"Collagen disease" due to carbamazepine (Tegretol).

Simpson, J. R.

doi:10.1136/bmj.2.5527.1434

Cited by 37 publications

(15 citation statements)

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“…The pattern of reaction occurring in our patient has not, to our knowledge, been previously documented with carbamazepine overdosage, although a bullous skin eruption has been described with imipramine, a chemically related compound, (Freeman and Raza, 1965). A lupus erythematosus-like phenomenon has been described with therapeutic dosage of carbamazepine (Simpson, 1966) and the relationship of therapy to the serological findings in our patient is not clear. However, before the overdose, our patient had taken very few carbamazepine tablets.…”

Section: Discussioncontrasting

confidence: 51%

Bullous skin eruption associated with carbamazepine overdosage

Godden¹,

McPhie²

1983

Postgraduate Medical Journal

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Section: Discussioncontrasting

confidence: 51%

Bullous skin eruption associated with carbamazepine overdosage

Godden¹,

McPhie²

1983

Postgraduate Medical Journal

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“…There have been occasional reports of agranUlocytosis, aplastic anemia, thrombocytopenia and cholestatic jaundice. In a few cases, carbamazepine had been implicated in urticarial rashes, Stevens-Johnson syndrome, lupus erythematosus, exfoliative dermatitis, alopecia, lichenoid eruptions and generalized erythema (1)(2)(3)(4). The patient reported here had experienced 2 episodes of cutaneous reaction with spontaneous recovery on stopping Tegretol and prompt recurrence on resuming it.…”

Section: Commentmentioning

confidence: 85%

Patch test diagnosis of exfoliative dermatitis due to carbamazepine

Camarasa¹

1985

Contact Dermatitis

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“…Phenytoin and ethosuximide intake have both been associated with the presence of circulating antinuclear 328 antibodies in occasional patients (Beernink & Miller 1973). Reversible instances of systemic lupus erythematosus have been reported in patients taking phenytoin, primidone, carbamazepine and ethosuximide (Rallison et al 1961;Simpson 1966;Singsen et al 1976). Rarely, phenytoin intake has been associated with the development of a pseudolymphoma syndrome with Hodgkin-like histological features, which resolves on cessation of the drug (Saltzstein & Ackerman 1959).…”

Section: Haematological Effectsmentioning

confidence: 99%

The Risk-Benefit Ratio of Anticonvulsant Drugs

Eadie

1987

Medical Toxicology

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The concepts underlying the notion of a risk-benefit ratio for anticonvulsant therapy have determined the development of the drug treatment of epilepsy over many years. The risk element in the ratio arises from the various possible physical and psychological adverse effects of anticonvulsant therapy; the benefit is derived from the capacity of therapy to prevent seizures and thus reduce the disadvantages which result from having epilepsy. The physical adverse effects of anticonvulsant therapy may involve many tissues and organs. The drugs tend to depress cerebral, cerebellar and brain stem function, and may slow peripheral nerve conduction. Prolonged intake may cause hypocalcaemia and osteoporosis, folate depletion, various haematological and immunological abnormalities, and overgrowth of subcutaneous and gingival tissues. Idiopathic reactions may involve the skin, lymph nodes, liver, pancreas, kidney and thyroid, and cause electrolyte disturbances, while maternal anticonvulsant intake during pregnancy may be associated with an increased incidence of fetal malformations. Local reactions may occur at drug administration sites, and anticonvulsants may interact pharmacokinetically and pharmacodynamically with co-administered drugs. The taking of anticonvulsants sometimes has undesirable psychological effects on both the patient and his or her family. Epilepsy itself often results in adverse psychological consequences which emanate from the uncertainty and insecurity that is imposed by the unpredictable occurrence of seizures, from the limitations epilepsy sets on the patient's lifestyle and employment prospects, and from unfavourable community attitudes towards the disorder. Contemporary anticonvulsant therapy is not fully effective in all patients, but to the extent that it can control seizures it may help alleviate these emotional burdens that are a result of epilepsy. The consensus of present day medical opinion is that, in the great majority of clinical situations, the benefits of anticonvulsant therapy outweigh the disadvantages. However, to provide optimal management for individual patients, the risk-benefit ratio of therapy must be repeatedly assessed at all stages of a patient's treatment, and therapeutic decisions taken in the light of the ratio as it applies to the individual.

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"Collagen disease" due to carbamazepine (Tegretol).

Cited by 37 publications

References 0 publications

Bullous skin eruption associated with carbamazepine overdosage

Bullous skin eruption associated with carbamazepine overdosage

Patch test diagnosis of exfoliative dermatitis due to carbamazepine

The Risk-Benefit Ratio of Anticonvulsant Drugs

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