Bullous skin eruption associated with carbamazepine overdosage

Godden, D. J.; McPhie, J L

doi:10.1136/pgmj.59.691.336

Cited by 12 publications

(5 citation statements)

References 6 publications

(5 reference statements)

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“…To evaluate the model derived in the previous section we have mainly used Monte Carlo calculated SPR values but also the experimental values in Godden (1983). The Monte Carlo calculations were performed with the E G S ~ code.…”

Section: Calculation Of Datamentioning

confidence: 99%

“…These supplementary data showed no significant difference between SPR for kerma and dose for 2 > 0.25 cm. Godden (1983). The reason for this choice of Z ' is that the radius of the circular field, equivalent in terms of scatter dose to the square field, is nearly equal to f = s/2x0.891= 0.561s, where P is the average radius from the centre to the periphery of the square (Bjarngard and Siddon 1982).…”

Section: Comparison With Measured Data For 6oco Ymentioning

confidence: 99%

“…The line through the measured data has the same slope as the one for the calculated values but goes below the origin. Negative SPR values are impossible, so one is led to conclude that the TAR(O, d ) values inGodden (1983) are not compatible with the interpretation expressed by equation (11). This, in turn, may be a consequence of the fact that Godden's data are normalised to TAR(O, 0.5) = 1.…”

mentioning

confidence: 92%

“…d / ( f + d ) with F = 0.561s. TAR values were taken fromGodden (1983). The reason for this choice of Z ' is that the radius of the circular field, equivalent in terms of scatter dose to the square field, is nearly equal to f = s/2x0.891= 0.561s, where P is the average radius from the centre to the periphery of the square(Bjarngard and Siddon 1982).For comparison, figure10includes S P R ( Z ) for kerma from the Monte Carlo calculations, i.e.…”

mentioning

confidence: 99%

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Description of the scatter component in photon-beam data

Bjärngard

Petti

1988

Phys. Med. Biol.

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Kerma scatter-to-primary ratios (SPR) were calculated, using a Monte Carlo code, for water irradiated by photon beams (200 keV monoenergetic, 60Co gamma, 4 and 15 MV x-rays). The SPR at depth d on the centreline of a circular field of radius r can be described by SPR = aZ + bZ2, with Z = rd/(r + d). The proportionality constant a is determined by the linear attenuation coefficient mu and the ratio r/d. The coefficient b for the second-order term depends on r/d and energy, the latter by being proportional to mu3. This relation between SPR and Z can facilitate analysis of beam data in terms of the contributions from primary and scattered photons, in particular for small depths and small fields where measurements are difficult. This is illustrated by examining measured TAR data for 60Co gamma beams. While the relation between SPR and Z is not fully explained, it is demonstrated qualitatively that SPR approximately equal to aZ if only first-order scatter is to be accounted for.

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Section: Calculation Of Datamentioning

confidence: 99%

Section: Comparison With Measured Data For 6oco Ymentioning

confidence: 99%

mentioning

confidence: 92%

mentioning

confidence: 99%

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Description of the scatter component in photon-beam data

Bjärngard

Petti

1988

Phys. Med. Biol.

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“…It is still unclear whether this hematologic effect may be connected to the skin reaction. Interestingly, other antibiotics, such as ciprofloxacin, have been also reported to produce skin disorders, concurrently with severe neutropenia (7,8). Bullous skin lesions have been described in association with a variety of drugs (7), but the mechanism of skin adverse reaction is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Nafcillin-Induced Bullous Skin Eruption with Granulocytopenia in a Patient with End-Stage Renal Disease

et al. 2012

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Nafcillin is an antibiotic used for infections due to penicillin-resistant Staphylococcus aureus. In general, the adverse reactions to nafcillin have not been frequent and serious. We report here a new type of adverse reaction to nafcillin in a patient with end-stage renal disease in whom nafcillin caused the unexpected complication of bullous drug eruption and subseqent neutropenia. Three weeks after the start of intravenous nafcillin for the treatment of peritoneal dialysis peritonitis, the patient developed blisters on his right ankle. These became progressive and widespread, with bullae affecting most of the body surface. In addition, neutropenia developed three days after the appearance of bullous skin lesions. Spontaneous recovery of skin lesions and neutropenia was observed after the withdrawal of naficillin. When treating patients with chronic renal failure, physicians should be aware of these rare but potentially severe adverse reactions.

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The vesiculobullous reaction pattern

Weedon

2010

Weedon's Skin Pathology

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Bullous skin eruption associated with carbamazepine overdosage

Cited by 12 publications

References 6 publications

Description of the scatter component in photon-beam data

Description of the scatter component in photon-beam data

Nafcillin-Induced Bullous Skin Eruption with Granulocytopenia in a Patient with End-Stage Renal Disease

The vesiculobullous reaction pattern

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