Collagen-chitosan scaffold modified with Au and Ag nanoparticles: Synthesis and structure

Rubina, Margarita S.; Kamitov, E.E.; Zubavichus, Ya. V.; Peters, G. S.; Naumkin, A. V.; Süzer, Şefik; Vasil’kov, A. Yu.

doi:10.1016/j.apsusc.2016.01.107

Cited by 39 publications

(15 citation statements)

References 39 publications

(38 reference statements)

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“…MVS technique is well-proven and effective route to make composites with tailored magnetic, antibacterial, and catalytic properties. The MVS efficacy for preparing biopolymers and their hybrids with biologically active metal NPs has already been demonstrated [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of chitosan–copper nanocomposites and their fungicidal activity against two sclerotia-forming plant pathogenic fungi

et al. 2017

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In this report, the metal-vapor synthesis (MVS) was used for the preparation of copper nanoparticles which was then used for the preparation of chitosan-copper nanocomposite. The antifungal activity of Cu@Chit NCs against two sclerotium-forming plant pathogenic fungi Sclerotium rolfsii (S. rolfsii) and Rhizoctonia solani (R. solani) AG-4 was evaluated in vitro and their effects on hyphal morphology, and sclerotia formation were observed for the first time. The NCs were prepared through impregnation of chitosan with colloid solution of copper nanoparticles in organic solvent (acetone or toluene). Transmission electron microscopy shows that the particles have predominantly spherical form, polydisperse character, the mean diameter about 2-3 nm and a rather uniform distribution in the chitosan matrice. Analysis of the small angle scattering curves suggests that the copper particles in the NCs with the size of B2 nm are mostly located in the chitosan pores with the same size. The effect of Cu@Chit NCs on fungal growth reveals some significant inhibitory activity against two tested fungi. The highest level of inhibition against S. rolfsii and R. solani AG-4 was observed using the high concentrations of Cu@Chit NC prepared using acetone as a solvent. A loss of the cytoplasm content, cytoplasmic coagulation, irregular shape of mycelia, or destruction in the hyphae was confirmed. The experiments demonstrate that the Cu@Chit NC synthesized via MVS using acetone was more effective than that of toluene in inhibiting fungal hyphae growth against R. solani AG-4 and S. rolfsii. The results show that the Cu@Chit NCs are fungicidal against both the tested fungus at high concentrations and the fungicidal or fungistatic activity is dependent on the tested fungus species.

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of chitosan–copper nanocomposites and their fungicidal activity against two sclerotia-forming plant pathogenic fungi

et al. 2017

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“…Thus, the observed changes in parameters can be explained by the significant contribution of the surface silver atoms . In addition, a distorted local structure of AgNPs also contributes to the effect .…”

Section: Resultsmentioning

confidence: 96%

“…It has been demonstrated that MVS can be employed for successful preparation of gauze bandage loaded with AgNPs with pronounced antibacterial activity against S. aureus , Staphylococcus haemolyticus , P. aeruginosa , Klebsiella pneumoniae , Escherichia coli , and Moraxella spp . The composite metal‐bearing materials based on commercially available collagen–chitosan dressing material for treatment of wounds and burns were prepared by means of MVS .…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of biomedical collagen–chitosan scaffolds with entrapped ibuprofen and silver nanoparticles

Rubina

Said-Galiev

Naumkin

et al. 2019

Polymer Engineering & Sci

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In this work, the preparation and characterization of a novel multifunctional collagen–chitosan material containing silver nanoparticles and nonsteroid anti‐inflammatory drug ibuprofen is described. As a starting material, the commercially available collagen–chitosan scaffold was used. Drug‐loading procedure was performed via supercritical CO2‐assisted impregnation technique. Silver nanoparticles were prepared via metal vapor synthesis and introduced into the composite biopolymer matrix. An analysis of the small‐angle X‐ray scattering profiles revealed that silver nanoparticles are characterized by having a logarithmic normal size distribution with the maximum at 25 nm. The average size of particles determined from the broadening of diffraction peaks is in a good agreement with this result. The surface of the materials was characterized by X‐ray photoelectron spectroscopy. The in vitro release kinetics of ibuprofen in phosphate buffer solution with pH = 7.4 from prepared materials was studied. The drug release to solution is governed by Fickian diffusion and can be described within the Ritger–Peppas model. Introduction of silver nanoparticles has no effect on the diffusion mechanism. The as‐prepared materials are promising for the medical applications such as dressings for treatments of infected wounds and infection preventing. These materials can act as a matrix for transdermal drug administration. POLYM. ENG. SCI., 59:2479–2487, 2019. © 2019 Society of Plastics Engineers

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“…Chitosan is polysaccharide, which can be obtained during deacetylation of chitin . Chitosan is also often applied as a biomaterial because it promotes wound and burn healing during skin regeneration . Chitosan can be used for drug delivery system, surgical thread, and as a component of wound dressing materials .…”

Section: Introductionmentioning

confidence: 99%

“…Silver nanoparticles may have different sizes, morphology, and stability depending on methods of preparation . Material based on collagen/chitosan and silver nanoparticles was already synthesized as a three‐dimensional (3D) scaffold for regenerative medicine . The aim of this work was to obtain new composite based on collagen/chitosan films with silver nanoparticles in order to obtain new material with antimicrobial properties for the potential biomedical application as a wound dressing material.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of collagen/chitosan composites with silver nanoparticles

2019

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In this work, thin films made from the blends of collagen and chitosan with silver nanoparticles were prepared and their properties, which are important for potential biomedical applications, were studied. Thin biopolimeric film was obtained by solvent evaporation from collagen/chitosan mixture containing silver nanoparticles. Mechanical properties of the composites were tested in dry condition using a mechanical testing machine. Microstructure of films was analyzed by Atomic Force Microscope. The surface properties were analyzed by contact angle measurements using hydrophilic and hydrophobic liquids. In addition, antimicrobial properties of collagen/chitosan/silver composites were tested during the microbiological test. It was found that the addition of silver nanoparticles to collagen/chitosan film affects several of its properties. Microbiological studies showed that obtained collagen/chitosan/silver nanoparticles materials possess bacteriostatic activity against Staphylococcus aureus.

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Collagen-chitosan scaffold modified with Au and Ag nanoparticles: Synthesis and structure

Cited by 39 publications

References 39 publications

Synthesis and characterization of chitosan–copper nanocomposites and their fungicidal activity against two sclerotia-forming plant pathogenic fungi

Synthesis and characterization of chitosan–copper nanocomposites and their fungicidal activity against two sclerotia-forming plant pathogenic fungi

Preparation and characterization of biomedical collagen–chitosan scaffolds with entrapped ibuprofen and silver nanoparticles

Preparation and characterization of collagen/chitosan composites with silver nanoparticles

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