Collagen-based 3D structures—versatile, efficient materials for biomedical applications

David, Geta

doi:10.1016/b978-0-12-816897-4.00035-7

Cited by 10 publications

(14 citation statements)

References 127 publications

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“…Thus, drug-coated ceramics [ 19 ] are described in the literature, as well as composites of hydrogels introduced into the ceramics [ 20 ] to achieve a delayed drug release. Other approaches are also being pursued by adding the ceramics as powder or granules to scaffolds made of hydrogels [ 21 ] or xerogels, e.g., collagen [ 22 , 23 ]. This offers the advantage of being able to print these gels by means of 3D extrusion.…”

Section: Introductionmentioning

confidence: 99%

Inverse 3D Printing with Variations of the Strand Width of the Resulting Scaffolds for Bone Replacement

et al. 2021

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The objective of this study was to vary the wall thicknesses and pore sizes of inversely printed 3D molded bodies. Wall thicknesses were varied from 1500 to 2000 to 2500 µm. The pores had sizes of 500, 750 and 1000 µm. The sacrificial structures were fabricated from polylactide (PLA) using fused deposition modeling (FDM). To obtain the final bioceramic scaffolds, a water-based slurry was filled into the PLA molds. The PLA sacrificial molds were burned out at approximately 450 °C for 4 h. Subsequently, the samples were sintered at 1250 °C for at least 4 h. The scaffolds were mechanically characterized (native and after incubation in simulated body fluid (SBF) for 28 days). In addition, the biocompatibility was assessed by live/dead staining. The scaffolds with a strand spacing of 500 µm showed the highest compressive strength; there was no significant difference in compressive strength regardless of pore size. The specimens with 1000 µm pore size showed a significant dependence on strand width. Thus, the specimens (1000 µm pores) with 2500 µm wall thickness showed the highest compressive strength of 5.97 + 0.89 MPa. While the 1000(1500) showed a value of 2.90 + 0.67 MPa and the 1000(2000) of 3.49 + 1.16 MPa. As expected for beta-Tricalciumphosphate (β-TCP), very good biocompatibility was observed with increasing cell numbers over the experimental period.

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Section: Introductionmentioning

confidence: 99%

Inverse 3D Printing with Variations of the Strand Width of the Resulting Scaffolds for Bone Replacement

et al. 2021

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“…Protein-based micro-and nanoparticles present high biodegradability and low thermal and mechanical stability, which lead to collagen chemical modification (maintaining its native structure) or the combination with other biopolymers or synthetic polymers or even inorganic materials, also allowing to increase the system functionality [107,108] and to modulate their properties according to the desired application. Thus, several collagen-based micro-and nanoparticles were developed with different biomedical applications (tissue engineering, imagistic/diagnosis, and drug/gene delivery) [109].…”

Section: Nanomicrofibers and Nanomicroparticlesmentioning

confidence: 99%

“…Modifications were introduced into the emulsification method to improve the delivery kinetics, maintaining the collagen meshwork biocompatibility as the replacement of chemicals for photochemical crosslinking or the use of self-assembling collagen fiber reconstitution [ 114 ]. However, the emulsion method remains to present poor control of the particle shape and size, as well as a reduced loading level [ 109 ], which leads to the exploitation of other strategies to produce micro- or nanoparticles.…”

Section: Development Of Marine-polymeric Architectures Via Ionic Lmentioning

confidence: 99%

Marine-Derived Polymers in Ionic Liquids: Architectures Development and Biomedical Applications

et al. 2020

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Marine resources have considerable potential to develop high-value materials for applications in different fields, namely pharmaceutical, environmental, and biomedical. Despite that, the lack of solubility of marine-derived polymers in water and common organic solvents could restrict their applications. In the last years, ionic liquids (ILs) have emerged as platforms able to overcome those drawbacks, opening many routes to enlarge the use of marine-derived polymers as biomaterials, among other applications. From this perspective, ILs can be used as an efficient extraction media for polysaccharides from marine microalgae and wastes (e.g., crab shells, squid, and skeletons) or as solvents to process them in different shapes, such as films, hydrogels, nano/microparticles, and scaffolds. The resulting architectures can be applied in wound repair, bone regeneration, or gene and drug delivery systems. This review is focused on the recent research on the applications of ILs as processing platforms of biomaterials derived from marine polymers.

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“…Collagen-based 3D materials are extensively used in biomedical applications (scaffolds in tissue engineering, lab models for drug screening, modern wound dressings, and drug delivery devices) due to their protein properties. The most envisaged are: biocompatibility and inherent bio-functionality enabling cells' proliferation and differentiation, coupled with haemostatic properties, low immunogenicity, a rich chemistry and high water-holding capacity [1,2]. A porous architecture facilitates cell adhesion and improves flexibility and substance permeability, finally promoting 3D structure biomimicry [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…A porous architecture facilitates cell adhesion and improves flexibility and substance permeability, finally promoting 3D structure biomimicry [3,4]. However, the application of this protein for biomedical devices, as a unique raw source, is limited by some disadvantages, such as the poor mechanical and antibacterial properties, fast degradation, modification and processing difficulties, some batch-to-batch variations and risk of human transgenic disease transmission [1]. Cross-linking (by physical, chemical or combined techniques) and combination with other polymers (natural or synthetic) or materials (i.e., ceramics) may be used as topical, convenient routes to avoid the biopolymer drawbacks and to improve/control the physico-chemical and biological properties of collagen-based materials, to meet specific needs [1,[5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Comparative Investigation of Collagen-Based Hybrid 3D Structures for Potential Biomedical Applications

et al. 2021

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Collagen is a key component for devices envisaging biomedical applications; however, current increasing requirements impose the use of multicomponent materials. Here, a series of hybrid collagen-based 3D materials, comprising also poly(ε-caprolactone) (PCL) and different concentrations of hyaluronic acid (HA)—in dense, porous or macroporous form—were characterized in comparison with a commercially available collagen sponge, used as control. Properties, such as water uptake ability, water vapour sorption, drug loading and delivery, were investigated in correlation with the material structural characteristics (composition and morphology). Methylene blue (MB) and curcumin (CU) were used as model drugs. For spongeous matrices, it was evidenced that, in contrast to the control sample, the multicomponent materials favor improved sustained release, the kinetics being controlled by composition and cross-linking degree. The other characteristics were within an acceptable range for the intended purpose of use. The obtained results demonstrate that such materials are promising for future biomedical applications (wound dressings and lab models).

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Collagen-based 3D structures—versatile, efficient materials for biomedical applications

Cited by 10 publications

References 127 publications

Inverse 3D Printing with Variations of the Strand Width of the Resulting Scaffolds for Bone Replacement

Inverse 3D Printing with Variations of the Strand Width of the Resulting Scaffolds for Bone Replacement

Marine-Derived Polymers in Ionic Liquids: Architectures Development and Biomedical Applications

Comparative Investigation of Collagen-Based Hybrid 3D Structures for Potential Biomedical Applications

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