Collagen/aminated MWCNTs nanocomposites for biomedical applications

Chakoli, Ali Nabipour; He, Jin Mei; Huang, Yu Dong

doi:10.1016/j.mtcomm.2018.03.003

Cited by 13 publications

(6 citation statements)

References 27 publications

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“…The presence of zirconia NPs enhanced the triple-helical structure of collagen, and the derived scaffolds were used for studying the direct electron transfer of proteins and for the fabrication of biosensors [170]. Similarly, various studies were reported on the development of composite blends of collagen and carbon nanotubes (CNTs) [171]. For instance, collagen was embedded with CNTs with varying concentrations of carboxylated CNTs [172].…”

Section: Role Of Npmentioning

confidence: 99%

Materials science perspective of multifunctional materials derived from collagen

Ashokkumar

Ajayan

2020

International Materials Reviews

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Grand challenges facing humanity today are closely linked to the rapid exhaustion of natural resources in conjunction with the massive growth of industrial production that sustains the booming world population. The processing of animal skin waste to create collagen-based materials has the potential to provide an eco-friendly method to develop multifunctional materials such as films, sponges/scaffolds, fibers, gels, etc., that could contribute to technological advancements in different sectors. Hence in this review, we present methods for potential improvements in the development of collagen-based materials from a materials science perspective. We explored different possible approaches for utilizing collagen to generate multifunctional materials that exhibit outstanding properties, in combination with mechanical robustness and chemical stability. In sum, this review will present collagen as an eco-friendly resource that can be used to produce multifunctional, recyclable, biocompatible, and biodegradable materials that are ideal for new technologies in materials science, biomedicine, and environmental remediation.

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Section: Role Of Npmentioning

confidence: 99%

Materials science perspective of multifunctional materials derived from collagen

Ashokkumar

Ajayan

2020

International Materials Reviews

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“…Furthermore, the main peak component in binding energy corresponds to approximately 285 eV in the C 1s spectrum and 534 eV in the O 1s spectrum, while the peak at 400 eV corresponds to N 1s in the wide survey scan spectrum ( Figure 1 f). 37 A decrease was observed in the atomic percent of carbon (from 98.30 to 91.37%), while an increase was observed in the atomic percent of oxygen (from 1.70 to 7.53%) after oxidation of MWCNT. After the modification of PAMAM, the N 1s peak was observed, and its atomic percent was found to be 4.01% ( Figure 1 g).…”

Section: Resultsmentioning

confidence: 92%

“…The presence of the amide bond is indicative of the successful synthesis of MWCNT-PAMAM (Figure d,e). Furthermore, the main peak component in binding energy corresponds to approximately 285 eV in the C 1s spectrum and 534 eV in the O 1s spectrum, while the peak at 400 eV corresponds to N 1s in the wide survey scan spectrum (Figure f) . A decrease was observed in the atomic percent of carbon (from 98.30 to 91.37%), while an increase was observed in the atomic percent of oxygen (from 1.70 to 7.53%) after oxidation of MWCNT.…”

Section: Resultsmentioning

confidence: 93%

Carbon Nanotube-Incorporated Nanofibers for Immunosensor Preparation against CD36

Demirkol

2023

ACS Omega

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The increased serum concentration of CD36 is significantly associated with atherosclerosis, insulin resistance, and diabetes mellitus. Currently, there is no sensor system used for the detection of CD36 in the clinical field. Therefore, there is a need to develop a sensor system for the detection of CD36. The large surface area/volume ratio and controllable surface conformation of electrospun nanofibers (ENs) make them highly attractive for immunosensor applications. In the present study, PS/MWCNT-PAMAM ENs were produced and used as an immobilization matrix of Anti-CD36. Thus, the electrochemical behavior of the developed nanocomposite-based ENs and their usage potential were investigated for immunosensor applications. First, an oxidized multiwall carbon nanotube (MWCNT-OH) was synthesized and modified with a polyamidoamine generation 3 (PAMAM G3) dendrimer. The synthesized MWCNT-PAMAM nanocomposite was mixed with polystyrene (PS) solutions at different ratios to produce bead-free, smooth, and uniform PS/MWCNT-PAMAM ENs. PS/MWCNT-PAMAM ENs were accumulated on a screen-printed carbon electrode (SPCE) using the electrospinning technique. A biofunctional surface on the PS/MWCNT-PAMAM EN-coated SPCE was created using carbodiimide chemistry by covalent immobilization of Anti-CD36. The analytic performance characteristics of the developed PS/MWCNT-PAMAM/Anti-CD36 immunosensor were determined by performing electrochemical measurements in the presence of the CD36 protein. The linear detection range was found to be from 5 to 40 ng/mL, and the limit of detection was calculated as 3.94 ng/mL for CD36. The developed PS/MWCNT-PAMAM/Anti-CD36 immunosensor also displayed high tolerance to interference substances, good repeatability, and high recovery percent (recovery%) for artificial blood serum analysis.

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“…Electrophilic addition of alkyl halides results in the formation of alkyl and hydroxyl groups, whereas nucleophilic addition of amine-based nucleophiles leads to amino-functionalized CNTs (Scheme 2). As an example of electrophilic reaction, Friedel-Crafts acylation between MWCNT Scheme 1 Fluorination and further functionalization of carbon nanotubes and p-aminobenzoic acid in the presence of polyphosphoric acid renders MWCNT-NH 2 (Scheme 2a), which can be used for further functionalization with poly(l-lactide) polymer [57] or with collagen using glutamic acid as a crosslinker [58]. As an example of nucleophilic addition, SWCNT can be alkylated by the treatment with t-butyllithium and subsequent reoxidation of the intermediates to obtain neutral CNTs decorated with tert-butyl moieties [59].…”

Section: Electrophilic and Nucleophilic Additionsmentioning

confidence: 99%

Carbon Nanotubes in Biomedicine

et al. 2020

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Nowadays, biomaterials have become a crucial element in numerous biomedical, preclinical, and clinical applications. The use of nanoparticles entails a great potential in these fields mainly because of the high ratio of surface atoms that modify the physicochemical properties and increases the chemical reactivity. Among them, carbon nanotubes (CNTs) have emerged as a powerful tool to improve biomedical approaches in the management of numerous diseases. CNTs have an excellent ability to penetrate cell membranes, and the sp 2 hybridization of all carbons enables their functionalization with almost every biomolecule or compound, allowing them to target cells and deliver drugs under the appropriate environmental stimuli. Besides, in the new promising field of artificial biomaterial generation, nanotubes are studied as the load in nanocomposite materials, improving their mechanical and electrical properties, or even for direct use as scaffolds in body tissue manufacturing. Nevertheless, despite their beneficial contributions, some major concerns need to be solved to boost the clinical development of CNTs, including poor solubility in water, low biodegradability and dispersivity, and toxicity problems associated with CNTs' interaction with biomolecules in tissues and organs, including the possible effects in the proteome and genome. This review performs a wide literature analysis to present the main and latest advances in the optimal design and characterization of carbon nanotubes with biomedical applications, and their capacities in different areas of preclinical research.

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Collagen/aminated MWCNTs nanocomposites for biomedical applications

Cited by 13 publications

References 27 publications

Materials science perspective of multifunctional materials derived from collagen

Materials science perspective of multifunctional materials derived from collagen

Carbon Nanotube-Incorporated Nanofibers for Immunosensor Preparation against CD36

Carbon Nanotubes in Biomedicine

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