The intensifying pace of research based on cross-cultural studies in the social sciences necessitates a discussion of the unique challenges of multi-sited research. Given an increasing demand for social scientists to expand their data collection beyond WEIRD (western, educated, industrialized, rich, and democratic) populations, there is an urgent need for transdisciplinary conversations on the logistical, scientific, and ethical considerations inherent of this kind of scholarship. As a group of social scientists engaged in cross-cultural research in psychology and anthropology, we guide prospective cross-cultural researchers through some of the complex scientific and ethical challenges involved in this type of work. Such challenges involve (a) study site selection, (b) culturally appropriate research methods, and (c) community involvement. We aim to shed light on some of the difficult ethical quandaries inherent in of this type of high-profile research. Our recommendation emphasizes a community-centered approach, in which the desires of the community regarding research methodology, community involvement, results distribution, and data sharing are held in highest regard by the researchers.