Collaborative Brazilian pediatric renal transplant registry (CoBrazPed‐RTx): A report from 2004 to 2018

Abstract

The Brazilian collaborative registry for pediatric renal transplantation began in 2004 as a multicenter initiative aimed at analyzing, reporting, and disseminating the results of pediatric renal transplantation in Brazil. Data from all pediatric renal transplants performed from January 2004 to May 2018 at the 13 participating centers were analyzed. A total of 2744 pediatric renal transplants were performed in the thirteen participating centers. The median age at transplantation was 12.2 years, with the majority being male recipients (56%). The main underlying diseases were CAKUT (40.5%) and glomerulopathy (28%). 1981 (72%) of the grafts were from deceased donors (DD). Graft survival at one year (censored by death) was 94% in the live donor group (LD) and 91% in the DD group (log‐rank test P < 0.01). The patient’s survival at one and 5 years was 97% and 95% for the LD group and 96% and 93% for the DD group (log‐rank test P = 0.02). The graft loss rate was 19% (n = 517), more frequently caused by vascular thrombosis (n = 102) and chronic graft nephropathy (n = 90). DD recipients had 1.6 (1.0‐2.2) times greater chance of death and 1.5 (1.2‐1.8) times greater chance of graft loss compared to LD recipients. The mortality rate was 5.4% (n = 148), mainly due to infection (n = 69) and cardiovascular disease (n = 28). The results of this collaborative pediatric renal transplant record are comparable to other international registries, although we still have a high infection rate as a cause of death.

Indications, Challenges, and Characteristics of Successful Implementation of Perioperative Registries in Low Resource Settings: A Systematic Review

“…They were all carried out within individual countries, with eleven being multi-centre studies. The data software included Research Electronic Data Capture (REDCap) used by three hospitals [15][16][17]; four further studies used unspecified apps, two of which were hosted in the United States of America (USA), where the principal investigators were located [18][19][20][21], one used FILE MAKER Pro [22], and the remaining two registries used locally designed software [23,24]. The databases were located outside the nations where the data collection was conducted in four sites, mainly in the USA and the remaining sites used local storage [18,19].…”

“…The databases were located outside the nations where the data collection was conducted in four sites, mainly in the USA and the remaining sites used local storage [18,19]. Researchers with specific registry objectives typically initiated implementation efforts (n = 10) [15][16][17][18][19][22][23][24][25][26]. Details of the included studies are shown in Table 1.…”

“…Finance-related challenges included insufficient funds to organise a team, build infrastructure, and pay data collectors' salaries, as well as rapid depreciation of local currencies resulting in difficulties paying data collector salaries in lower-income countries by investigators from higher-income countries [15, 17-19, 22, 23], and high costs To identify risk factors [17,23] 3…”

Oral findings in kidney transplant children and adolescents

“…According to the Brazilian Transplant Registry, congenital and hereditary diseases are the primary causes of renal failure in children from birth to 4 years old. Between the ages of 5 and 14 years, renal failure is mostly caused by hereditary conditions, nephrotic syndrome and systemic diseases, whereas the main underlying diseases are congenital anomalies of the kidneys and the urinary tract (CAKUT) (40.5%) and glomerulopathy (28%) 5 …”

“…Between the ages of 5 and 14 years, renal failure is mostly caused by hereditary conditions, nephrotic syndrome and systemic diseases, whereas the main underlying diseases are congenital anomalies of the kidneys and the urinary tract (CAKUT) (40.5%) and glomerulopathy (28%). 5…”