Colitis Cystica Profunda Simulating Rectal Carcinoma

Kayaçeti̇n, Ertuğrul; Kayaçetin, Serra

doi:10.1080/00015458.2005.11679722

Cited by 9 publications

(5 citation statements)

References 12 publications

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“…For example, colitis cystica profunda is characterized by misplacement of mucin-filled crypts through the muscularis mucosae into the submucosa and muscle layer of the colon. 12 Extracellular mucin occurs in some cases mimicking mucinous adenocarcinoma of the colon. A similar lesion has been described in the solitary rectal ulcer syndrome and has been misinterpreted as adenocarcinoma of the rectum.…”

Section: Discussionmentioning

confidence: 99%

Mucin-containing Rokitansky-Aschoff Sinuses With Extracellular Mucin Deposits Simulating Mucinous Carcinoma of the Gallbladder

Albores‐Saavedra

Galliani

Chablé-Montero

et al. 2009

American Journal of Surgical Pathology

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Rokitansky-Aschoff sinuses (R-As) are epithelial invaginations that extend down the gallbladder wall through the smooth muscle gaps and by this pathway they reach the subserosal connective tissue. We report here 5 cases of mucin-containing R-As that ruptured, and as a result, extracellular mucin escaped into the adjacent stroma. They were compared with 10 mucinous carcinomas of the gallbladder. Three cases of mucin-containing R-As accompanied by abundant extracellular mucin deposits with epithelial strips, glands and papillary structures were misinterpreted as mucinous carcinomas. Because of this, the patients were subjected to a second unnecessary radical surgical procedure. In the remaining 2 cases, the extracellular mucin associated with R-As was acellular and regarded as focal. Three patients were men and 2 women whose ages ranged from 2 to 71 years (average age 52 y). The youngest patient was a 2-year-old boy in whom the mucin-containing R-As were discovered incidentally by magnetic resonance imaging. He was later diagnosed with metachromatic leukodystrophy. The remaining 4 patients complained of right upper quadrant pain and had a thickened gallbladder wall identified by computed tomography and magnetic resonance imaging. There were gallstones in 3 patients. The R-As located in the lamina propria contained mucin but were not cystically dilated whereas those located in the subserosa were mucin-filled and often cystically dilated. Detached fragments of biliary epithelium, small glands, and papillary structures lacking cytologic atypia and mitotic figures were identified in the abundant mucin deposits located in the subserosa of 3 cases. The overlying surface gallbladder epithelium exhibited papillary hyperplasia with focal intestinal metaplasia in 2 patients, one of which had metachromatic leukodystrophy. The lack of reactivity for carcinoembryonic antigen and p53 and the low proliferative activity as measured by MIB-1 labeling index provided additional support to the benign nature of the lesion. Clues to separate mucin-containing R-As from mucinous carcinoma are provided. All 5 patients with mucin-containing R-As are disease free 8 months to 7 years after surgery (median follow-up of 39 mo).

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Section: Discussionmentioning

confidence: 99%

Mucin-containing Rokitansky-Aschoff Sinuses With Extracellular Mucin Deposits Simulating Mucinous Carcinoma of the Gallbladder

Albores‐Saavedra

Galliani

Chablé-Montero

et al. 2009

American Journal of Surgical Pathology

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“…Existen alrededor de 200 casos de colitis quística profunda descritos en la literatura mundial y en la forma de afectación difusa, menos de 30 casos (1,(3)(4)(5)(6). La etiología es desconocida.…”

Section: Discussionunclassified

“…La ecoendoscopia nos puede ayudar a diferenciar la enfermedad del cáncer, visualizando quistes hipoecoicos en la submucosa, sin infiltración de las capas más profundas, ni de los ganglios locales, descartando así el cáncer. La TAC y la resonancia magnética también pueden apoyar el diagnóstico (2,3,8,9).…”

Section: Discussionunclassified

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Colitis quística profunda

Álvarez

García

Miguel

et al. 2008

Rev. esp. enferm. dig.

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Colitis cystica profunda is a rare benign disease, characterized by the presence of mucin-filled cysts in the submucosa layer of colon, which forms polypoid lesions. The most habitual type of clinical presentation is localized, at distal colon or in the rectum, and more rarely appears like a diffuse afectation of colon. We present a case of colitis cystica profunda with diffuse afectation of whole colon, which definitive diagnosis was for the histological finds of the endoscopy macrobiopsys realized to colon's polypoid lesions.

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“…CCP is a rare benign disease characterized by mucin-filled cysts beneath the muscularis mucosa [1]. Knowledge of this pathological entity is important as it can mimic a well-differentiated adenocarcinoma of the rectum and therefore could lead to unnecessary surgical resection [2]. EUS, computed tomography, and MRI are useful for diagnosis of CCP [3,4]; however, the definitive diagnosis is based on endoscopic biopsies, which should be large and deep enough to include the submucosal layer, or resected surgical E-Videos ▶ Fig.…”

Section: B C)mentioning

confidence: 99%

Colitis cystica profunda mimicking mucinous adenocarcinoma of the rectum diagnosed by endoscopic submucosal dissection

Abe¹,

Hamamoto²,

Nagai³

et al. 2020

Endoscopy

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Video 1 Endoscopic submucosal dissection of colitis cystica profunda in the lower rectum along with resection of the tumor using the pocket-creation and clip-with-line methods. ▶ Fig. 3 The resected specimen. a Photograph of the resected specimen, approximately 9 × 6 cm in size. b Macroscopic view of the resected specimen, showing several cystic lesions containing mucin. c Histological images of the resected specimen stained with hematoxylin and eosin, showing colitis cystica profunda without findings of dysplasia or malignancy (× 12.5).

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Colitis Cystica Profunda Simulating Rectal Carcinoma

Cited by 9 publications

References 12 publications

Mucin-containing Rokitansky-Aschoff Sinuses With Extracellular Mucin Deposits Simulating Mucinous Carcinoma of the Gallbladder

Mucin-containing Rokitansky-Aschoff Sinuses With Extracellular Mucin Deposits Simulating Mucinous Carcinoma of the Gallbladder

Colitis quística profunda

Colitis cystica profunda mimicking mucinous adenocarcinoma of the rectum diagnosed by endoscopic submucosal dissection

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