Colistin-resistance mcr genes in Klebsiella pneumoniae from companion animals

Wang, Guizhen; Liu, Hongtao; Feng, Yuyang; Zhang, Zhiyuan; Hu, Huimin; Liu, Jiayang; Qiu, Lihao; Guo, Zhimin; Huang, Jing; Qiu, Jiazhang; Du, Cheng

doi:10.1016/j.jgar.2021.02.023

Cited by 7 publications

(8 citation statements)

References 5 publications

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“…Among seven studies reporting the detection of mcr genes in dogs, only three studies from China reported detection of the mcr-1 gene. This was in relation to the detection of several strains of mcr-1-producing K. pneumoniae and E. coli from fecal samples, rectal swabs, and clinical samples [98][99][100]. The mcr-1 gene was harbored by the IncI2, IncX4, and IncHI2 plasmids [98].…”

Section: Mcr Genes In Dogsmentioning

confidence: 89%

“…Except for mcr-6 and mcr-7, all the other mcr genes have been reported from dogs. Wang et al (2021) reported the detection of mcr-2, mcr-3, mcr-4, mcr-5, mcr-9, and mcr-10 in K. pneumoniae isolates from fecal samples in China. Interestingly, associations between mcr-1 and mcr-3 or mcr-5 were reported [100].…”

Section: Mcr Genes In Dogsmentioning

confidence: 99%

“…Wang et al (2021) reported the detection of mcr-2, mcr-3, mcr-4, mcr-5, mcr-9, and mcr-10 in K. pneumoniae isolates from fecal samples in China. Interestingly, associations between mcr-1 and mcr-3 or mcr-5 were reported [100]. The mcr-3 gene was also reported in E. coli ST10 co-expressing bla CTX-M-55 isolated from clinical samples in Thailand [101].…”

Section: Mcr Genes In Dogsmentioning

confidence: 99%

“…In Beijing, characteristics of K. pneumoniae in humans and companion animals were largely different, and mcr genes and bla NDM were not present in the genomes of K. pneumoniae isolated from humans [99]. In another study, researchers suspected that farm animals were the source of mcr genes in diseased dogs and cats (without colistin treatment) [100]. The environment is also an important factor in the spread of mcr genes such as mcr-1, mcr-3, and mcr-7.1, as well as other ARGs [112].…”

Section: Source Of Mcr Genes In Petsmentioning

confidence: 99%

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Mobile Colistin Resistance (mcr) Genes in Cats and Dogs and Their Zoonotic Transmission Risks

et al. 2022

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Background: Pets, especially cats and dogs, represent a great potential for zoonotic transmission, leading to major health problems. The purpose of this systematic review was to present the latest developments concerning colistin resistance through mcr genes in pets. The current study also highlights the health risks of the transmission of colistin resistance between pets and humans. Methods: We conducted a systematic review on mcr-positive bacteria in pets and studies reporting their zoonotic transmission to humans. Bibliographic research queries were performed on the following databases: Google Scholar, PubMed, Scopus, Microsoft Academic, and Web of Science. Articles of interest were selected using the PRISMA guideline principles. Results: The analyzed articles from the investigated databases described the presence of mcr gene variants in pets including mcr-1, mcr-2, mcr-3, mcr-4, mcr-5, mcr-8, mcr-9, and mcr-10. Among these articles, four studies reported potential zoonotic transmission of mcr genes between pets and humans. The epidemiological analysis revealed that dogs and cats can be colonized by mcr genes that are beginning to spread in different countries worldwide. Overall, reported articles on this subject highlight the high risk of zoonotic transmission of colistin resistance genes between pets and their owners. Conclusions: This review demonstrated the spread of mcr genes in pets and their transmission to humans, indicating the need for further measures to control this significant threat to public health. Therefore, we suggest here some strategies against this threat such as avoiding zoonotic transmission.

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Section: Mcr Genes In Dogsmentioning

confidence: 89%

Section: Mcr Genes In Dogsmentioning

confidence: 99%

Section: Mcr Genes In Dogsmentioning

confidence: 99%

Section: Source Of Mcr Genes In Petsmentioning

confidence: 99%

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Mobile Colistin Resistance (mcr) Genes in Cats and Dogs and Their Zoonotic Transmission Risks

et al. 2022

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“…In accordance with 'One Health', it is also crucial to monitor the distribution of mcr genes in animals, particularly in companion animals, since antimicrobial agents used in companion animals are often more closely related to ones used in humans ( 16 , 17 ), thus antimicrobial resistance (AMR) risks should not be ignored. In certain studies, mcr genes have been identified in companion animals' populations of different species, such as various mcr variants in K. pneumoniae ( 18 ), mcr-1 in E. coli ( 19 ), mcr-8 in K. pneumoniae , mcr-9 in E. hormaechei ( 20 ). It is evident from these data that companion animals play a significant role in the dissemination of the mcr gene.…”

Section: Introductionmentioning

confidence: 99%

Emergence and Transmission of Plasmid-Mediated Mobile Colistin Resistance Gene mcr-10 in Humans and Companion Animals

et al. 2022

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Colistin was considered as the last-resort drug against severe clinical infections caused by multidrug-resistant Gram-negative pathogens. Mobile colistin resistance ( mcr ) genes and its variants carried by plasmids have been reported in diverse niches in recent years, and yet few studies reported carriage of mcr-10 in ECC strains of companion animal origin.

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Global epidemiology and genetic diversity of mcr-positive Klebsiella pneumoniae: A systematic review and genomic analysis

Liu,

Wu,

Zhao

et al. 2024

Environmental Research

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Colistin-resistance mcr genes in Klebsiella pneumoniae from companion animals

Cited by 7 publications

References 5 publications

Mobile Colistin Resistance (mcr) Genes in Cats and Dogs and Their Zoonotic Transmission Risks

Mobile Colistin Resistance (mcr) Genes in Cats and Dogs and Their Zoonotic Transmission Risks

Emergence and Transmission of Plasmid-Mediated Mobile Colistin Resistance Gene mcr-10 in Humans and Companion Animals

Global epidemiology and genetic diversity of mcr-positive Klebsiella pneumoniae: A systematic review and genomic analysis

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