Colistin resistance gene mcr-1 harboured on a multidrug resistant plasmid

Abstract

All samples were taken as part of standard care procedures. We thank Christina Gerstmann for excellent technical assistance and our collaboration partners from DZIF and RESET for providing the isolates. We declare no competing interests.

Identification of a novel plasmid-mediated colistin-resistance gene, mcr-2, in Escherichia coli, Belgium, June 2016

“…. mcr-1 was detected in 12.4% (n = 13) of the E. coli isolates, of which six and seven were from calves and piglets, respectively [3,4]. In the present study, we analysed porcine and bovine colistin-resistant Escherichia coli isolates that did not show presence of mcr-1 and identified a novel plasmid-mediated colistin resistance-conferring gene, mcr-2.…”

“…Following the report of of mcr-1 detection in China in November 2015 [1], we screened 105 colistin-resistant Escherichia coli (colistin minimum inhibitory concentration (MIC) 4-8 mg/L [2]) isolated during 2011-12 from passive surveillance of diarrhoea in 52 calves and 53 piglets in Belgium [3]. mcr-1 was detected in 12.4% (n = 13) of the E. coli isolates, of which six and seven were from calves and piglets, respectively [3,4].…”

Epidemiology of antimicrobial resistance in bloodstream infections

“…82 Plasmid-mediated colistin resistance (via mcr-1 colistin resistance gene) has recently described in E. coli isolates worldwide from mainly livestock and less frequently in human samples. [84][85][86][87][88][89] The implications of this finding may be horrendous since the offending plasmid can easily be transferred between E. coli strains including those with epidemic potential (e.g. ST131) and to K. pneumoniae and P. aeruginosa.…”

The emerging problem of bacterial resistance in cancer patients; proceedings of a workshop held by MASCC “Neutropenia, Infection and Myelosuppression” Study Group during the MASCC annual meeting held in Berlin on 27–29 June 2013

“…A new gene mediating resistance to colistin (mcr-1) has been described recently on a multidrug-resistant plasmid [17]. This development could prove very dangerous to neutropenic patients infected with multidrug-resistant Gram-negative bacteria.…”