Coliform meningitis in the newborn.

Heckmatt, J Z

doi:10.1136/adc.51.8.569

Cited by 36 publications

(17 citation statements)

References 11 publications

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“…As for the survival rate, a greater mean birth weight among survivors of this infection was observed by McCracken and Mize,4 Hechmatt, 5 Overall,1 and Bortolussi and colleagues.8 A similar trend was seen in our study in which neonates of greater birth weight had a higher survival rate (92%) than neonates in the lower birth weight group (69%). A higher proportion of our patients with meningitis were girls.…”

Section: Resultssupporting

confidence: 76%

Long-term Outcome of Neonatal Meningitis

Franco

Cornelius²,

Andrews³

1992

Arch Pediatr Adolesc Med

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Section: Resultssupporting

confidence: 76%

Long-term Outcome of Neonatal Meningitis

Franco

Cornelius²,

Andrews³

1992

Arch Pediatr Adolesc Med

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“…Most cases of neonatal or postneurosurgical meningitis are now caused by the Enterobacteriaceae or Pseudomonas (7,9,11). The mortality rate and frequency of neurological sequelae remain high (2,17).…”

mentioning

confidence: 99%

Mecillinam-Ampicillin Synergism in Experimental Enterobacteriaceae Meningitis

Scheld

Fink

Fletcher

et al. 1979

Antimicrob Agents Chemother

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The in vitro activities of mecillinam, a new f)-amidinopenicilhin, and ampicillin, alone and in combination, against an Escherichia coli strain and a Klebsiella pneumoniae strain were compared, and these results were correlated with their respective activities in vivo in experimental meningitis. The mecillinam-ampicillin combination was synergistic in vitro against both strains when tested by a modified checkerboard technique (bacteriostatic synergy). However when quantitative bactericidal synergy studies were made, the relative bactericidal rate of the combination was more rapid than that of either drug alone ("bactericidal synergy") against the Escherichia coli isolate only. In a rabbit model of Enterobacteriaceae meningitis, in vivo bactericidal activity correlated with results obtained in vitro. Both drugs were administered by continuous intravenous infusion for 8 h. Serum and cerebrospinal fluid antibiotic levels were similar to those achieved in humans. Cerebrospinal fluid bacterial concentrations (colonyforming units [CFU] per milliliter) were quantitatively titrated at 2-h intervals. Both drugs, alone or the combination, were ineffective against the K. pneumoniae strain in vivo (change in titer <1 log in 8 h). In contrast, the combination produced a markedly enhanced bactericidal effect against the E. coli strain (mean + standard deviation, decrease of log1o CFU per milliliter of 3.65 ± 1.02) compared with those of ampicillin alone (decrease of log1o CFU per milliter of 0.07 ± 0.8) and mecillinam alone (decrease of logio CFU per milliliter of 1.6 ± 0.05) (P < 0.001). When bactericidal synergism can be demonstrated for mecillinam-ampicillin in vitro in a case of gram-negative-bacillary meningitis this combination may be useful in the therapy of the illness.

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“…Neonatal meningitis, when caused by group B streptococci or Escherichia coli, has a mortality rate of 15 to 50% (3,4,9,10,15,21). Ampicillin plus a parenteral aminoglycoside, standard therapy for this disease, does not always effect clinical and microbiological cure.…”

mentioning

confidence: 99%

“…In time-kill evaluations, ampicillin (3.0 [Lg/ml) and penicillin (0.75 ,tg/ml) effected 2.5 to 3.5 logi0 reductions in numbers of colony-forming units. The addition of 4 ,tg of cefotaxime per ml or 8 to 16 Neonatal meningitis, when caused by group B streptococci or Escherichia coli, has a mortality rate of 15 to 50% (3,4,9,10,15,21). Ampicillin plus a parenteral aminoglycoside, standard therapy for this disease, does not always effect clinical and microbiological cure.…”

mentioning

confidence: 99%

Activity of moxalactam and cefotaxime alone and in combination with ampicillin or penicillin against group B streptococci

Landesman¹,

Corrado²,

Cherubin³

et al. 1981

Antimicrob Agents Chemother

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The activities of moxalactam and cefotaxime, alone and combined with ampicillin or penicillin, against 40 isolates of group B streptococci were assessed by using the microtiter broth dilution, checkerboard, and time-kill techniques. Neonatal meningitis, when caused by group B streptococci or Escherichia coli, has a mortality rate of 15 to 50% (3,4,9,10,15,21). Ampicillin plus a parenteral aminoglycoside, standard therapy for this disease, does not always effect clinical and microbiological cure. Although numerous factors, e.g., prematurity, play roles in determining the poor outcome of neonatal meningitis, there is definitely room for improvement in the antimicrobial therapy of this disease.Moxalactam and cefotaxime, two relatively new beta-lactam derivatives, hold promise for therapy of neonatal meningitis caused by gramnegative bacteria. The minimal inhibitory concentrations (MICs) of these agents for most strains of E. coli range from 0.06 to 0.125 ,ug/ml (7,17,18

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Coliform meningitis in the newborn.

Cited by 36 publications

References 11 publications

Long-term Outcome of Neonatal Meningitis

Long-term Outcome of Neonatal Meningitis

Mecillinam-Ampicillin Synergism in Experimental Enterobacteriaceae Meningitis

Activity of moxalactam and cefotaxime alone and in combination with ampicillin or penicillin against group B streptococci

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