Long-term Outcome of Neonatal Meningitis

Franco, Sofia; Cornelius, Victoria E.; Andrews, Billy F.

doi:10.1001/archpedi.1992.02160170047014

Cited by 40 publications

(40 citation statements)

References 11 publications

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“…A freqüência dessa lesão estrutural após a meningite bacteriana em crianças de diferentes idades é de 3,6" a 41,7% 27 . Sete crianças (12,7%) evoluíram com microcefalia, freqüência superior à relatada por outros autores, de 7,7% 13 a 11,5% 8 .…”

Section: Discussionunclassified

“…Em nossa casuística as alterações visuais ocorreram em 17 (30,9%) crianças, resultado semelhante aos de Franco et al 8 , que as observaram em 37% dos casos. O estrabismo tem sido a anormalidade mais freqüentemente relatada, em especial nas crianças com múltiplas deficiências 6 , fato observado por nós em 18,2% dos pacientes, todos com seqüelas graves.…”

Section: Discussionunclassified

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Meningite bacteriana neonatal: estudo prospectivo da evolução a longo prazo de 55 crianças

et al. 1996

Arq. Neuro-Psiquiatr.

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RESUMO -Foram estudadas prospectivamente 55 crianças que apresentaram meningite bacteriana no período neonatal, com o objetivo da analisar a frequência e o tipo de sequelas neurológicas. Todas as crianças nasceram a termo, sendo 38 do sexo masculino e 17 do feminino; a idade de início da doença variou de 3 a 28 dias. Os principais agentes etiológicos foram as enterobactérias. O tempo médio de seguimento foi 5 anos. A frequência de sequelas neurológicas foi 67,3%, representadas principalmente pelo atraso do desenvolvimento neuropsicomotor (58,2%), hidrocefalia (45,5%) e convulsões (34,5%). As alterações motoras graves ocorreram em 23,6% dos pacientes (tetraplegia, diplegia, hemiparesia e ataxia). As convulsões na fase aguda da doença e a cultura positiva do líquido cefalorraqueano estiveram associadas significativamente com a presença de sequelas. Na avaliação do desempenho escolar, realizada em 25 crianças, observaram-se dificuldades na aprendizagem em 48% dos casos, associadas significativamente à deficiência mental.PALAVRAS-CHAVE: recém-nascido, meningite, seguimento.Vários estudos têm mostrado que a meningite bacteriana neonatal representa causa importante de morbimortalidade infantil, apesar dos avanços nas áreas da terapêutica antimicrobiana e cuidados Neonatal bacterial meningitis: prospective study of the long term outcome of 55 childrenABSTRACT -Fifty-five infants who presented bacterial neonatal meningitis were prospectively studied to analyze the frequency and the type of sequelae. All the infants were full term newborns.There were 38 boys and 17 girls; the age of disease onset varied from 3 to 28 days. The causative organism was represented mainly by enterobacteriae. The median time of follow-up was 5 years. The frequency of neurologic sequelae was 63.7%, represented mainly by neuropsychomotor development delay (58.2%), hydrocephaly (45.5%) and convulsions (34.5%). Severe motor abnormalities ocurred in 23.6% of children (quadriplegia, diplegia, hemiparesia and ataxia). Convulsions in the acute phase of the disease and the positive cerebrospinal fluid culture were highly associated to sequelae. The school performance, obtained in 25 children, showed presence of disabilities in 48% of cases, which were significantly associated to mental retardation.

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Meningite bacteriana neonatal: estudo prospectivo da evolução a longo prazo de 55 crianças

et al. 1996

Arq. Neuro-Psiquiatr.

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“…Higher case fatality rates have been reported for gram negative organisms than for gram positive organisms [11,12]. Third generation cephalosporins and aminoglycosides have been used in treating gram negative neonatal sepsis and meningitis [13].…”

Section: Resultsmentioning

confidence: 99%

Neonatal Meningoventriculitis Due to Proteus Mirabilis – A Case Report

Juyal¹

2013

JCDR

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A five day old full term born baby was admitted to our Neonatal Intensive Care Unit with seizures, opisthotonous posture and was icteric upto thigh. Baby had a three day history of poor feeding, lethargy and abnormal body movements. Mother was a 29 years old primigravida and had a normal vaginal delivery at home. Sepsis profile of the patient was requested, lumbar puncture and ventricular tap was performed. Patient was put on third generation cephalosporins, aminoglycosides and phenobarbitone. Culture and sensitivity report of blood, Cerebro spinal fluid and ventricular fluid showed Proteus mirabilis. Computerized Tomography scan showed a large parenchymal lesion in the right frontal lobe and diffuse ependymal enhancement along both the lateral ventricles suggestive of meningoventriculitis. We hereby present a fatal case of neonatal meningoventriculitis due to Proteus mirabilis.

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“…The incidence of early-onset gram-negative meningitis has been stable. Recent studies found no difference in outcome between early-onset GBS meningitis and gramnegative meningitis, but early-onset had poorer outcome that late-onset GBS meningitis [3,4]. The most important known risk factors for sepsis are prematurity [5], lack of maternal anti-GBS IgG protection [6], placental infections, and prolonged rupture of the foetal membranes.…”

Section: Bacterial Infectionmentioning

confidence: 99%

Neonatal brain infections

Schneider

2011

Pediatr Radiol

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Infections of the brain in the neonatal period differ considerably from infections in the older child, due to a variety of age-specific factors that are related not only to the child, but also to the mother, and to specific pathogenic organisms. It has been recognized that clinical and neurological signs are often non-specific, sometimes scarce, and seldom correlate with the extent of neuroimaging findings, thus warranting early imaging to ensure timely therapy and improved outcome.

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Long-term Outcome of Neonatal Meningitis

Cited by 40 publications

References 11 publications

Meningite bacteriana neonatal: estudo prospectivo da evolução a longo prazo de 55 crianças

Meningite bacteriana neonatal: estudo prospectivo da evolução a longo prazo de 55 crianças

Neonatal Meningoventriculitis Due to Proteus Mirabilis – A Case Report

Neonatal brain infections

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