Cold stress provokes lung injury in rats co-exposed to fine particulate matter and lipopolysaccharide

Luo, Bin; Shi, Hong-Xia; Zhang, Kai; Wei, Qiaozhen; Niu, Jingping; Wang, Jun Ling; Hammond, S. Katharine; Liu, Sa

doi:10.1016/j.ecoenv.2018.10.064

Cited by 18 publications

(12 citation statements)

References 42 publications

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“…Cold stress was also reported to affect respiratory system through suppressing the macrophage phagocytic function of alveolar macrophage 12 . Particularly, cold stress may aggravate the lung injury caused by PM 2.5 , indicated by reduced lung function and worsened pathologic change in rat lung 13 . It is possible that PM 2.5 exposure combined with cold stress may also trigger the asthma.…”

Section: Introductionmentioning

confidence: 99%

“…12 Particularly, cold stress may aggravate the lung injury caused by PM 2.5 , indicated by reduced lung function and worsened pathologic change in rat lung. 13 It is possible that PM 2.5 exposure combined with cold stress may also trigger the asthma. Besides, potential effects of lower temperature on asthma may not occur immediately after exposure in childhood but presented in adulthood with symptomatic attacks, suggesting the contribution of childhood lower temperature exposure to the development of asthma.…”

Section: Introductionmentioning

confidence: 99%

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Childhood co‐exposure of cold stress and PM_2.5 aggravates the susceptibility and severity of asthma in adulthood of mice

Zhou

Geng

et al. 2020

Environmental Toxicology

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Both cold stress and ambient fine particle particulate matter (PM2.5) has been reported to aggravate and induce respiratory problems like asthma, but the mechanism involved in that has not been fully understood. Therefore, the present study is to explore the mechanism involved in the increased susceptibility and severity of asthma caused by cold stress and PM2.5 exposure. Urban PM2.5 of Shanghai was concentrated to simulate a PM2.5‐polluted environment with an average concentration of 400 μg/m3, where 1‐month young C57BL/6J mice were exposed for 2 months under cold stress (2°C). Co‐exposure of cold stress and PM2.5 in childhood of mice led to significant infiltration of inflammatory cells in the peribronchial region or airspaces and the thickening or fibrosis of alveolar septum, increased OVA‐specific IgE in serum and total cells, eosinophil cells, and the levels of inflammatory cytokines including IL‐4, IL‐8, IL‐1β, IL‐5, IL‐13, and IFN‐γ in bronchoalveolar lavage fluid (BALF) of asthma mice. Moreover, mice in co‐exposure group presented a significantly high cough feature, reduced catalase (CAT), glutathione (GSH), superoxide dismutase (SOD), and elevated malonaldehyde (MDA) elevated in BALF; increased ratio of Th2/Th1 and the markable inhibition of Th17 differentiation toward Treg cells in the adulthood of asthma mice. Cold stress and PM2.5 co‐exposure in childhood may promote the deterioration of asthma symptoms in adulthood of mice by increasing inflammatory cytokines, ROS formation, Th2/Th1 imbalance, and suppressing the differentiation of Th17 toward Treg cells, which will help to provide experimental references when making some therapeutic strategies in allergic diseases through focusing on some natural solutions.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Childhood co‐exposure of cold stress and PM_2.5 aggravates the susceptibility and severity of asthma in adulthood of mice

Zhou

Geng

et al. 2020

Environmental Toxicology

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“…There is a limitation to our study that we were not able to collect enough PM 2.5 samples for ne particulate matter components analysis. At the same location our group analyzed the PM 2.5 components and found elevated amounts of polycyclic aromatic hydrocarbons (PAHs) [44]. Future study should investigate the effect of major PM 2.5 components and the role of each one in the pathological process of PM 2.5 -induced ocular hypertension.…”

Section: Discussionmentioning

confidence: 91%

“…Airborne particulate matter (PM 2.5 ) collection Atmospheric PM 2.5 samples were obtained from January to October 2016 in Lanzhou, China, according to our previously described methods [44]. PM samples were gathered on glass ber lters by a ow air particle sampler (TH-150C, Wuhan Tianhong Instrument Factory, Wuhan, China) at a constant ow rate of 100 L/min.…”

Section: Methodsmentioning

confidence: 99%

Airborne particulate matter (PM2.5) triggers ocular hypertension through pyroptosis

Xing

Niu

et al. 2021

Preprint

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Background Particulate matter (PM) is strongly linked to human health and has detrimental effects on the eye. Studies have, however, focused on the ocular surface, with limited research on the impact of PM2.5 on intraocular pressure (IOP).Methods To investigate the impact of PM2.5 on IOP and the associated mechanism, C57BL/6 mouse eyes were topically exposed to a PM2.5 suspension for 3 months, and human trabecular meshwork (HTM) cells were subjected to various PM2.5 concentrations in vitro.Results The results revealed that the IOP increased gradually after PM2.5 exposure, and an upregulation of NLRP3 inflammasome, caspase-1, IL-1β, and GSDMD protein levels was observed in outflow tissues. PM2.5 exposure decreased HTM cell viability and affected contraction. Further, elevated ROS levels were observed as well as an activation of the NLRP3 inflammasome and downstream inflammatory factors caspase-1 and IL-1β. ROS scavenger or caspase-1 inhibitor treatment improved these PM2.5-induced changes.Conclusion This study provides novel evidence of the PM2.5-mediated development of ocular hypertension, which occurs as a result of increased oxidative stress and the subsequent induction of pyroptosis in trabecular meshwork cells.

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“…A prolonged stress led to a decrease in the level of Lactobacilli and an increase in the level of circulating kynurenine, since metabolic products of lactobacilli can modulate the metabolism of host kynurenine, inhibiting the expression of the metabolizing enzyme IDO1 in the intestine of mice [5]. Cold stress can lead to intestinal inflammation accompanied by changes in the microbiome of mice [6], rats [7] and humans [8]. The changes in the structure of the colon microbiome during acute stress in rats were characterized by a decrease in the number of Lactobacilli, Bifidobacteria and E. coli with normal enzymatic activity [7].…”

Section: Introductionmentioning

confidence: 99%

Effect of probiotic strains upon intestinal immune system under cold stress

et al. 2020

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Gut microbiome changes can be considered as a causative factor of stress-associated intestinal diseases. The aim of the investigation was to study the effects of the oral probiotic strains Lactobacillus casei LB 148 and E. coli EB 387 onto gut microbiota, as well as the intestinal immune system of rats Sprague Dawley in a healthy state and under cold stress. There are no strict official recommendations here in the Russian Federation for preclinical studies of new probiotic strains. Here we describe a method used to estimate the safety and effectiveness of the oral use of a probiotic. It is cheap and simple, so we recommend using it at least for the screening search of effective and safe probiotics. The number of Peyer’s patches in the small intestine of rats in different compartments was counted and then compared between different groups of rats. After cold stress there was a change in the number of Peyer’s patches together with microbiota shifts. Lactobacillus casei LB 148 as well as E. coli EB 387 protected the immune system against the stress effects.

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Cold stress provokes lung injury in rats co-exposed to fine particulate matter and lipopolysaccharide

Cited by 18 publications

References 42 publications

Childhood co‐exposure of cold stress and PM_2.5 aggravates the susceptibility and severity of asthma in adulthood of mice

Childhood co‐exposure of cold stress and PM_2.5 aggravates the susceptibility and severity of asthma in adulthood of mice

Airborne particulate matter (PM2.5) triggers ocular hypertension through pyroptosis

Effect of probiotic strains upon intestinal immune system under cold stress

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Cold stress provokes lung injury in rats co-exposed to fine particulate matter and lipopolysaccharide

Cited by 18 publications

References 42 publications

Childhood co‐exposure of cold stress and PM2.5 aggravates the susceptibility and severity of asthma in adulthood of mice

Childhood co‐exposure of cold stress and PM2.5 aggravates the susceptibility and severity of asthma in adulthood of mice

Airborne particulate matter (PM2.5) triggers ocular hypertension through pyroptosis

Effect of probiotic strains upon intestinal immune system under cold stress

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Childhood co‐exposure of cold stress and PM_2.5 aggravates the susceptibility and severity of asthma in adulthood of mice

Childhood co‐exposure of cold stress and PM_2.5 aggravates the susceptibility and severity of asthma in adulthood of mice