Cold atmospheric pressure plasma for treatment of chronic wounds: drug or medical device?

Krämer, Axel; Conway, Barbara R.; Meissner, Konrad; Scholz, Fritz; Rauch, Bernhard; Moroder, Anke; Ehlers, Anne P.; Meixner, Alfred J.; Heidecke, Claus–Dieter; Partecke, Lars Ivo; Kietzmann, Manfred; Assadian, Ojan

doi:10.12968/jowc.2017.26.8.470

Cited by 14 publications

(8 citation statements)

References 83 publications

(71 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meanwhile, first case reports exist on beneficial plasma effects in cancer patients. The kINPen MED is accredited as medical device in Germany and the European Union for skin surface treatment and decontamination [ 57 ], although the classification as a device is at least controversial for wound treatment [ 58 ]. Final stage head and neck cancer patients often suffer from microbial infections [ 59 ].…”

Section: Introductionmentioning

confidence: 99%

Cold Atmospheric Plasma in the Treatment of Osteosarcoma

Gümbel

Bekeschus

Gelbrich

et al. 2017

IJMS

View full text Add to dashboard Cite

Human osteosarcoma (OS) is the most common primary malignant bone tumor occurring most commonly in adolescents and young adults. Major improvements in disease-free survival have been achieved by implementing a combination therapy consisting of radical surgical resection of the tumor and systemic multi-agent chemotherapy. However, long-term survival remains poor, so novel targeted therapies to improve outcomes for patients with osteosarcoma remains an area of active research. This includes immunotherapy, photodynamic therapy, or treatment with nanoparticles. Cold atmospheric plasma (CAP), a highly reactive (partially) ionized physical state, has been shown to inherit a significant anticancer capacity, leading to a new field in medicine called “plasma oncology.” The current article summarizes the potential of CAP in the treatment of human OS and reviews the underlying molecular mode of action.

show abstract

Section: Introductionmentioning

confidence: 99%

Cold Atmospheric Plasma in the Treatment of Osteosarcoma

Gümbel

Bekeschus

Gelbrich

et al. 2017

IJMS

View full text Add to dashboard Cite

show abstract

“…For more details, refer to Figure 2 belongs to the group of direct cold plasma sources, whose mode of operation is based on integrating the treated tissue into the electrical circuit, inducing a stimulating electric current flow into the tissue in the presence of strong electric fields in addition to exposure to reactive oxygen and nitrogen species, charged particles, and mild UV-A radiation. The manufacturer declared the conformity according to EU Guideline 93/42/EEC for medical devices, although the classification of plasma medical devices for wound treatment seems controversial [35,36]. Pursuant to the manufacturer, the treatment area of the class IIa medical device covered 27.5 cm 2 , in which a low-temperature plasma is ignited directly in the ambient air layer, covering the skin surface.…”

Section: Cap Applicationmentioning

confidence: 99%

Topically confined enhancement of cutaneous microcirculation by cold plasma

Borchardt¹,

Helmke²,

Ernst³

et al. 2022

Skin Pharmacol Physiol

View full text Add to dashboard Cite

Introduction: We aim to explore potentials and modalities of cold atmospheric pressure plasma (CAP) for the subsequent development of therapies targeting an increased perfusion of the lower leg skin tissue. In this study, we addressed the question whether the microcirculation enhancement is restricted to the tissue in direct contact with plasma or if adjacent tissue might also benefit. Methods: A dielectric barrier discharge (DBD)-generated CAP device exhibiting an electrode area of 27.5 cm² was used to treat the anterior lower leg of ten healthy subjects for 4.5 minutes. Subsequently, hyperspectral imaging (HIS) was performed to measure tempo-spatially resolved characteristics of microcirculation parameters in superficial (up to 1 mm) and deeper (up to 5 mm) skin layers. Results: In the tissue area covered by the plasma electrode, DBD-CAP treatment enhances most of the perfusion parameters. The maximum oxygen saturation (StO2) increase reached 8 %, the near infrared perfusion index (NIR) increases by a maximum of 4 %, and the maximum tissue hemoglobin (THI) increase equaled 14 %. Tissue water index (TWI) was lower in both the control and the plasma group thus not affected by the DBD-CAP treatment. Yet, our study reveals that adjacent tissue is hardly affected by the enhancements in the electrode area and the effects are locally confined. Conclusion: Application of DBD-CAP to the lower leg resulted in enhancement of cutaneous microcirculation that extended 1 h beyond the treatment period with localization to the tissue area in direct contact with the cold plasma. This suggests the possibility of tailoring application schemes for topically confined enhancement of skin microcirculation, e.g. in the treatment of chronic wounds.

show abstract

“…The energy source needed to create plasma may be thermal, chemical or electrical in nature [1]. Based on its thermal properties, the role of plasma in medicine has expanded to include a wide range of applications including cancer [2], wound healing [3], infectious disease [4], and dentistry [5]. Plasma is also being used with increasing frequency in dermatology [6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Skin Tissue Effects of Two-Pass Helium Plasma Treatment in Comparison to Nitrogen Plasma Using a Swine Model

Ruff¹

2021

BJSTR

View full text Add to dashboard Cite

Background: Helium plasma is a new technology for dermal resurfacing. Objectives: To compare the depth of thermal effect produced by a two-pass skin treatment protocol for a helium plasma system in comparison to nitrogen plasma.Methods: A 6-month-old domestic pig was anesthetized, intubated, and ventilated. Thirty-six 1.5 cm x 1.5 cm square treatment sites were drawn on both shaved flanks. Energy was applied to each flank using helium and nitrogen plasma systems. Helium treatment was delivered as linear/non-overlapping strokes in single and double passes at 1 cm/sec treatment speed. Helium plasma device settings were 20% Power (energy density 8.6 J/cm 2 ) and 40% power (energy density 17.8 J/cm 2 ) with 4 lpm of helium flow. Nitrogen treatment was delivered in consecutive pulses using the PSR3 treatment protocol (4.0 J, 2.5 Hz pulse rate and energy density 14.1 J/cm 2 ). Histology assessments of thermal injury were made from harvested tissue samples. Results:The shallowest depth of thermal effect was 0.25±0.07mm obtained using the helium plasma at 20% energy setting and a single pass. The deepest thermal effect was 0.72±0.07mm obtained using the helium plasma at 40% energy setting with two passes. The maximum depth of thermal effect associated with the nitrogen plasma was 0.60±0.07 mm and equivalent to helium plasma using 20% and 40% power with two passes. Conclusions:There are no significant differences in the depth of thermal effect associated with a two-pass treatment protocol for the helium-based plasma system when compared to PSR3 treatment with a nitrogen-based plasma skin resurfacing system.

show abstract

Cold atmospheric pressure plasma for treatment of chronic wounds: drug or medical device?

Cited by 14 publications

References 83 publications

Cold Atmospheric Plasma in the Treatment of Osteosarcoma

Cold Atmospheric Plasma in the Treatment of Osteosarcoma

Topically confined enhancement of cutaneous microcirculation by cold plasma

Evaluation of Skin Tissue Effects of Two-Pass Helium Plasma Treatment in Comparison to Nitrogen Plasma Using a Swine Model

Contact Info

Product

Resources

About