Colchicine in experimental alkaline burns of the rat esophagus: an old drug, a new indication?

Abstract

At non-toxic doses, colchicine was not effective in the treatment of alkaline esophageal burn in rats. Colchicine-like molecules with less adverse effects or colchicine itself in titrated doses may be hopeful in preventing the development of fibrosis in the alkaline burns of the esophagus.

Role of allopurinol on oxidative stress in caustic burn: cure for stricture?

“…Based on previous studies attesting to experimental caustic burn, we designated the present study in an analogous fashion where acute changes were studied at 72 h and chronic stages towards the development of esophageal stricture were studied after 28 days [2,3,11,12]. Strictures typically manifest between 4 and 6 weeks after the initial injury [1].…”

“…A thinner catheter was inserted through the feeding catheter for irrigation. The irrigation water came out through the channel between the two catheters [1] dithiobis (2-nitrobenzoic acid) for color development. The standard curve was used to calculate GSH content.…”

“…Although there is a huge sum of proposed treatment regiments, there is still no consensus for the treatment in these cases [1]. Stricture still is a serious problem and will not last since preventive strategies for especially the child, the psychotic patient and the drug addicted are inadequate.…”

The route of the catheter directly affects the volume needed in experimental corrosive esophagitis

“…1). This experimental procedure was schematically presented to be clearly understood in our article [5]. In our method, as the catheter was placed via the mouth, at the catheter there is a distance to the isolated esophageal segment, which filled with the corrosive agent during the burning procedure.…”

“…We reported several experimental studies previously [3][4][5][6][7]. In our studies, corrosive esophageal burn was induced by using the experimental model described previously with modifications [2].…”