The route of the catheter directly affects the volume needed in experimental corrosive esophagitis

Yukselen, Vahit; Oruç, Nevin; Özütemiz, Ömer

doi:10.1007/s00383-008-2249-y

Cited by 1 publication

(3 citation statements)

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“…[ 13 17 ] The amount of corrosive substance to create oesophageal burn in the oesophagus of rat varies from 0.3to 10 mL in the literature. [ 6 13 14 15 16 17 ] It has also been reported that the oesophageal volume of adult male rat is around 0.1-0.3 mL. [ 17 ] Our method allows the standardisation of the experimental model and operative techniques.…”

Section: Discussionmentioning

confidence: 99%

“…This is an important advantage of our model because the same pressure can be applied in the oesophagus of all rats and this allows us to standardise the burn process. In the other models,[ 13 14 15 16 17 ] there is confusion in the amount of corrosive substance that should be given to create corrosive burns. [ 13 17 ] The amount of corrosive substance to create oesophageal burn in the oesophagus of rat varies from 0.3to 10 mL in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, three corrosive oesophageal burn models that believed to be less invasive have been described by Yukselen[ 16 ] Senturk et al . [ 14 ] and Kalkan et al .…”

Section: Discussionmentioning

confidence: 99%

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A corrosive oesophageal burn model in rats: Double-lumen central venous catheter usage

Bakan

Çıralık

Kartal

2015

Afr J Paediatr Surg

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Background:We aimed to create a new and less invasive experimental corrosive oesophageal burn model using a catheter without a gastric puncture (gastrotomy).Materials and Methods:We conducted the study with two groups composed of 8 male rats. The experimental oesophageal burn was established by the application of 10% sodium hydroxide to the distal oesophagus under a pressure of 20 cmH2O, via 5-F double-lumen central venous catheter without a gastrotomy. The control group was given 0.9% sodium chloride. All rats were killed 24 h after administration of NaOH or 0.9% NaCl. Histologic damage to oesophageal tissue was scored by a single pathologist blind to groups.Results:The rats in the control group were observed to have no pathological changes. Corrosive oesophagitis (tissue congestion, oedema, inflammation, ulcer and necrosis) was observed in rats exposed to NaOH.Conclusion:We believe that an experimental corrosive oesophageal burn can safely be created under same hydrostatic pressure without a gastric puncture using this model.

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