COLCHIC - Occupational Exposure to Chemical Agents Database: Current Content and Development Perspectives

Vincent, R. J.; Jeandel, Brigitte

doi:10.1080/104732201460190

Cited by 46 publications

(27 citation statements)

References 2 publications

(2 reference statements)

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“…This means that the method is usable for making measurements for comparison with the HCl shortterm LV and that it can be used for making measurements for However, for methods using only one filter impregnated with 500 µL of 5% Na 2 CO 3 , such as the former MétroPol 009 method, there could be an underestimation for amounts of HCl higher than 5000 µg. Nevertheless, it was noted from the COLCHIC database (13) that no occupational HCl assessment using the former MétroPol 009 method exhibited concentrations as high as 5000 µg.…”

Section: Hcl Recovery and Breakthrough Testsmentioning

confidence: 96%

Evaluation of Sampling Methods for Measuring Exposure to Volatile Inorganic Acids in Workplace Air. Part 2: Sampling Capacity and Breakthrough Tests for Sodium Carbonate-Impregnated Filters

Demange

Oury

Rousset

2011

Journal of Occupational and Environmental Hygiene

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In France, the MétroPol 009 method used to measure workplace exposure to inorganic acids, such as HF, HCl, and HNO3, consists of a closed-face cassette fitted with a prefilter to collect particles, and two sodium carbonate-impregnated filters to collect acid vapor. This method was compared with other European methods during the development of a three-part standard (ISO 21438) on the determination of inorganic acids in workplace air by ion chromatography. Results of this work, presented in a companion paper, led to a need to go deeper into the performance of the MétroPol 009 method regarding evaluation of the breakthrough of the acids, both alone and in mixtures, interference from particulate salts, the amount of sodium carbonate required to impregnate the sampling filter, the influence of sampler components, and so on. Results enabled improvements to be made to the sampling device with respect to the required amount of sodium carbonate to sample high HCl or HNO3 concentrations (500 μL of 5% Na2CO3 on each of two impregnated filters). In addition, a PVC-A filter used as a prefilter in a sampling device showed a propensity to retain HNO3 vapor so a PTFE filter was considered more suitable for use as a prefilter. Neither the material of the sampling cassette (polystyrene or polypropylene) nor the sampling flowrate (1 L/min or 2 L/min) influenced the performance of the sampling device, as a recovery of about 100% was achieved in all experiments for HNO3, HCl, and HF, as well as HNO3+HF and HNO3+HCl mixtures, over a wide range of concentrations. However, this work points to the possibility of interference between an acid and salts of other acids. For instance, interference can occur through interaction of HNO3 with chloride salts: the stronger the acid, the greater the interference. Methods based on impregnated filters are reliable for quantitative recovery of inorganic volatile acids in workplace atmosphere but are valuable only in the absence of interferents.

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Section: Hcl Recovery and Breakthrough Testsmentioning

confidence: 96%

Evaluation of Sampling Methods for Measuring Exposure to Volatile Inorganic Acids in Workplace Air. Part 2: Sampling Capacity and Breakthrough Tests for Sodium Carbonate-Impregnated Filters

Demange

Oury

Rousset

2011

Journal of Occupational and Environmental Hygiene

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“…A level of exposure was then calculated for each job by multiplying concentration by frequency. The classification of exposure levels was based on measurement data available in Finland and France 29,30 and on exposure estimates generated for the EU member states in another arm (WOOD-RISK) of the larger study program (WOOD-RISK) to which this study also belongs. 12 In Denmark, exposure levels were estimated from the Danish exposure estimates in WOODEX, 31 mainly based on measurements of inhalable wood dust concentrations measured in different Danish and Finnish woodprocessing industries in the 1990s.…”

Section: Exposure Assessmentmentioning

confidence: 99%

Mutations in TP53 tumor suppressor gene in wood dust‐related sinonasal cancer

Holmila

Bornholdt

Heikkilä

et al. 2010

Intl Journal of Cancer

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The causal role of work-related exposure to wood dust in the development of sinonasal cancer has long been established by numerous epidemiologic studies. To study molecular changes in these tumors, we analyzed TP53 gene mutations in 358 sinonasal cancer cases with or without occupational exposure to wood dust, using capillary electrophoresis single-strand conformation polymorphism analysis and direct sequencing. A significant association between wood-dust exposure and adenocarcinoma histology was observed [adjusted odds ratio (OR) 12.6, 95% confidence interval (CI), 5.0-31.6]. TP53 mutations occurred in all histologies, with an overall frequency of 77%. TP53 mutation positive status was most common in adenocarcinoma (OR 2.0, 95% CI, 1.1-3.7; compared with squamous cell carcinoma), and mutation positivity showed an overall, nonsignificant association with wood-dust exposure (OR 1.6, 95% CI, 0.8-3.1). Risk of TP53 mutation was significantly increased in association with duration (!24 years, OR 5.1, 95% CI, 1.5-17.1), average level (>2 mg/m 3 ; OR 3.6, 95% CI, 1.2-10.8) and cumulative level (!30 mg/m 3 3 years; OR 3.5, 95% CI, 1.2-10.7) of wood-dust exposure; adjustment for formaldehyde affected the ORs only slightly. Smoking did not influence the occurrence of TP53 mutation; however, it was associated with multiple mutations (p 5 0.03). As far as we are aware, this is the first study to demonstrate a high prevalence of TP53 mutation-positive cases in a large collection of sinonasal cancers with data on occupational exposure. Our results indicate that mutational mechanisms, in particular TP53 mutations, are associated with work-related exposure to wood dust in sinonasal cancer.

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“…concrete) in mines, as well as in rooms with ineffi cient ventilation; workers performing tasks related to abrasive cleaning -of large surfaces, with the use of sand; workers involved in pouring liquid silica materials; -workers cleaning castings and repairing high---temperature furnaces; workers performing dry processing of ceramic ware, -refractories and abrasive products [3,6,7]. In the European Union, the number of workers exposed to crystalline silica, except for coal miners, is estimated to be over 2 million [8], and the data collected for many years at the national databases: COLCHIC in France [9] and MEGA in Germany [10], provide evidence that the determination of crystalline silica is one of the most prevalent analyses conducted in work environment. In Poland, according to the statistics of GUS (Central Statistical Offi ce), over 50 thousand people [2] are exposed to industrial dust at levels exceeding occupational exposure limits, which are the conditions conducive to the development of lung fi brosis.…”

Section: R E V I E W P a P E R Smentioning

confidence: 99%

Occupational Exposure Assessment for Crystalline Silica Dust: Approach in Poland and Worldwide

Maciejewska

2008

International Journal of Occupational Medicine and Environmental Health

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Crystalline silica is a health hazard commonly encountered in work environment. Occupational exposure to crystalline silica dust concerns workers employed in such industries as mineral, fuel-energy, metal, chemical and construction industry. It is estimated that over 2 million workers in the European Union are exposed to crystalline silica. In Poland, over 50 thousand people work under conditions of silica dust exposure exceeding the occupational exposure limit. The assessment of occupational exposure to crystalline silica is a multi-phase process, primarily dependent on workplace measurements, quantitative analyses of samples, and comparison of results with respective standards. The present article summarizes the approaches to and methods used for assessment of exposure to crystalline silica as adopted in different countries in the EU and worldwide. It also compares the occupational limit values in force in almost 40 countries. Further, it points out the consequences resulting from the fact that IARC has regarded the two most common forms of crystalline silica: quartz and cristobalite as human carcinogens. The article includes an inter-country review of the methods used for air sample collection, dust concentration measurements, and determination of crystalline silica. The selection was based on the GESTIS database which lists the methods approved by the European Union for the measurements and tests regarding hazardous agents. Special attention has been paid to the methods of determining crystalline silica. The author attempts to analyze the infl uence of analytical techniques, sample preparation and the reference materials on determination results. Also the operating parameters of the method, including limit of detection, limit of quantifi cation, and precision, have been compared.

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COLCHIC - Occupational Exposure to Chemical Agents Database: Current Content and Development Perspectives

Cited by 46 publications

References 2 publications

Evaluation of Sampling Methods for Measuring Exposure to Volatile Inorganic Acids in Workplace Air. Part 2: Sampling Capacity and Breakthrough Tests for Sodium Carbonate-Impregnated Filters

Evaluation of Sampling Methods for Measuring Exposure to Volatile Inorganic Acids in Workplace Air. Part 2: Sampling Capacity and Breakthrough Tests for Sodium Carbonate-Impregnated Filters

Mutations in TP53 tumor suppressor gene in wood dust‐related sinonasal cancer

Occupational Exposure Assessment for Crystalline Silica Dust: Approach in Poland and Worldwide

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