2008
DOI: 10.1111/j.1600-0528.2007.00424.x
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COL1A2 gene polymorphisms (Pvu II and Rsa I), serum calciotropic hormone levels, and dental fluorosis

Abstract: This study provides the first evidence of an association between polymorphisms in the COL1A2 gene with dental fluorosis in high fluoride exposed populations. Future studies are needed to confirm the association.

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Cited by 46 publications
(52 citation statements)
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References 23 publications
(44 reference statements)
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“…Rajasthan is severely affected by fluororsis problem. Huang et al, 2008 had reported that children with homozygous P allele of COL1A2 PvuII had about five times the risk of dental flouorosis compared to children with homozygous p allele after adjusting for age and gender [13]. COL1A2 gene polymorphism study is undertaken and study area is Jaipur District of Rajasthan, India.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Rajasthan is severely affected by fluororsis problem. Huang et al, 2008 had reported that children with homozygous P allele of COL1A2 PvuII had about five times the risk of dental flouorosis compared to children with homozygous p allele after adjusting for age and gender [13]. COL1A2 gene polymorphism study is undertaken and study area is Jaipur District of Rajasthan, India.…”
Section: Resultsmentioning
confidence: 99%
“…This association between the COL1A2 gene and dental fluorosis was only observed for children who came from endemic fluoride villages. It is possible that this polymorphism may be in linkage disequilibrium with a causal mutation in the same gene [13]. A casecontrol study was conducted in two blocks of Jaipur district of Rajasthan, India to investigate the COL1A2 gene polymorphisms with relation to dental fluorosis in Indian children.…”
Section: Introductionmentioning
confidence: 99%
“…However, the observed associations were not related to fluoride exposure (Wang et al, 2012). Huang et al (2008) found that homozygosity for the P allele of the COL1A2 PvuII (coding for the pro-alpha2 (I) chain of collagen) was associated with an increased risk for dental fluorosis compared to children carrying the homozygous genotype pp from the same fluoride-rich area (OR 4.85, 95 % CI 1.22-19.32), but the risk was not elevated when the control population was recruited from low-fluoride areas.…”
Section: Effects Of Genotypesmentioning
confidence: 99%
“…Similarly, Dawson 5 and Huang et al, 4 concluded that some polymorphisms of the COL1A2 gene are involved in the development of dental fluorosis. However, Escobar-García et al, 6 and Pragya & Vandana 8 argue that there is no evidence of association between polymorphisms of the COL1A2 gene and dental fluorosis in populations exposed to high concentrations of fluoride.…”
Section: Referencesmentioning
confidence: 99%
“…Procollagen molecules organize themselves into long, thin fibrils that intertwine in the spaces around the cells, resulting in the formation of mature and strong Type I collagen fibers. 4 Due to its important role in bone formation and architecture, mutations in the COL1A2 gene have been associated with a broad spectrum of diseases of bone, cartilage and blood vessels. Likewise, the…”
mentioning
confidence: 99%