Coix seed improves growth performance and productivity in post-weaning pigs by reducing gut pH and modulating gut microbiota

Li, Zhaolong; Lin, Zhongning; Zheng, Libing; Feng, Zhen; Chen, Qi; Deng, Su-Fang; Li, Zhenwu; Yan, Yong; Zhao-yang, Ying

doi:10.1186/s13568-019-0828-z

Cited by 18 publications

(13 citation statements)

References 49 publications

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“…(Pairwise comparison using T test and multiple comparisons with Tukey test). Biomarker features were screened using Metastats (version 1.0) and LEfSe as described by Li [59].…”

Section: Taxonomic Analysesmentioning

confidence: 99%

The different dietary sugars modulate the composition of the gut microbiota in honeybee during overwintering

Wang

Liu

et al. 2020

BMC Microbiol

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Background: The health of honeybee colonies is critical for bee products and agricultural production, and colony health is closely associated with the bacteria in the guts of honeybees. Although colony loss in winter is now the primary restriction in beekeeping, the effects of different sugars as winter food on the health of honeybee colonies are not well understood. Therefore, in this study, the influence of different sugar diets on honeybee gut bacteria during overwintering was examined. Results: The bacterial communities in honeybee midguts and hindguts before winter and after bees were fed honey, sucrose, and high-fructose syrup as winter-food were determined by targeting the V3-V4 region of 16S rDNA using the Illumina MiSeq platform. The dominant microbiota in honeybee guts were the phyla Proteobacteria (63.17%), Firmicutes (17.61%; Lactobacillus, 15.91%), Actinobacteria (4.06%; Bifidobacterium, 3.34%), and Bacteroidetes (1.72%). The dominant taxa were conserved and not affected by season, type of overwintering sugar, or spatial position in the gut. However, the relative abundance of the dominant taxa was affected by those factors. In the midgut, microbial diversity of the sucrose group was higher than that of the honey and high-fructose syrup groups, but in the hindgut, microbial diversity of the honey and high-fructose groups was higher than that in the sucrose group. Sucrose increased the relative abundance of Actinobacteria (Bifidobacteriales Bifidobacteriaceae) and Alphaproteobacteria (Rhizobiales and Mitochondria) of honeybee midgut, and honey enriched the Bacteroidetes and Gammaproteobacteria (Pasteurellales) in honeybee hindgut. High-fructose syrup increased the relative abundance of Betaproteobacteria (Neisseriales: Neisseriaceae) of the midgut. Conclusion: The type of sugar used as winter food affected the relative abundance of the dominant bacterial communities in honeybee guts, not the taxa, which could affect the health and safety of honeybee colonies during overwintering. The presence of the supernal Alphaproteobacteria, Bifidobacteriales, and Lactobacillaceae in the gut of honeybees fed sucrose and cheaper than honey both indicate that sucrose is very suitable as the overwintering food for honeybees.

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“…(Pairwise comparison using T test and multiple comparisons with Tukey test). Biomarker features were screened using Metastats (version 1.0) and LEfSe as described by Li [59].…”

Section: Taxonomic Analysesmentioning

confidence: 99%

The different dietary sugars modulate the composition of the gut microbiota in honeybee during overwintering

Wang

Liu

et al. 2020

BMC Microbiol

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“…This is because bacteria in the gut, including Lactobacillus and Paraprevotella, have been proven to play an active and protective role in intestinal health of the host through producing antimicrobial molecules, competitive exclusion, and changing bile acid metabolism in the gut (69)(70)(71). Succinatimonas, Paludibacter, and Sphaerochaeta were found to produce volatile fatty acids including acetic acid, propionic acid, and succinic acid that could positively impact energy metabolism of the host and regulate hindgut pH to inhibit the growth of harmful bacteria (72)(73)(74)(75)(76)(77). Dietary supplementation of high-level vitamin B 12 depressed the richness of Acinetobacter and Bilophila that were inflammation-associated genera (78).…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Production Performance, Egg Quality, and Cecal Microbiota in Laying Hens Receiving Graded Levels of Vitamin B12

et al. 2021

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The objective of the study was to investigate the effect of fortified diets with standard vs. high levels of vitamin B12 on cecal microbiota composition, production performance, and eggshell quality of laying hens. Dietary treatments consisted of a basal diet with no supplementation of vitamin B12 or supplemented with 25, 100, and 400 μg/kg vitamin B12, respectively. A total of 432 laying hens were randomly assigned to four treatments with six replicates per treatment. No significant effect of dietary treatments on the production performance of hens was detected. The shell thickness of eggs from hens fed diet supplemented with 100 μg/kg of vitamin B12 was higher (P < 0.01) than that of eggs from hens fed control diet or supplemented with 25 μg/kg vitamin B12. The shell percentage of eggs from hens fed diet supplemented with 400 μg/kg of vitamin B12 was higher (P < 0.01) than that of eggs from hens fed other treatment diets. Dietary vitamin B12 did not modulate diversity of the cecal microbiota of the layers. At genus level, the cecal content from layers fed diet with supplemental level of 100 or 400 μg/kg of vitamin B12 had higher (P < 0.01) abundance of Faecalibacterium and lower (P < 0.05) abundance of Acinetobacter compared with the cecal content from layers fed other two diets. The abundance of Lactobacillus in the cecal samples from layers fed 100 μg/kg of supplemental level of vitamin B12 was higher (P < 0.05) than that from layers fed other three diets. The abundance of Butyricicoccus was higher (P < 0.05), while Bilophila was lower (P < 0.05) in the cecal content of layers fed 400 μg/kg of vitamin B12 diet compared with those from layers fed other three diets. The results of PICRUSt analysis indicated that 10 predicted metabolic functions of the cecal microbial communities were positively correlated to dietary vitamin B12 level. Overall, dietary supplementation of 100 or 400 μg/kg of vitamin B12 had equivalent effects and caused the significant change in composition and metabolic functions of cecal microorganisms, which could positively impact eggshell quality, metabolism, and gut health of laying hens.

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“…Eucommia ulmoides (EU) flavone, a Chinese herbal plant, contains several compounds which provide health-enhancing effects [ 121 ]. The leaf of this plant is a rich source of flavonoids [ 31 , 122 ] providing beneficial effects on health by direct scavenging of free radicals, inhibiting proinflammatory cytokines via suppressing ROS and nitric oxide, reducing inflammatory genes encompassing cyclooxygenases (COXs) and inducible nitric oxide synthase (iNOS), upregulating antioxidative enzymes, manipulating transcription factors such as NF- κ B and AP-1, and increasing the Nrf2 signaling pathway [ 123 , 124 ]. The in vitro protective effect of Eucommia ulmoides flavones against LPS-triggered enterocyte damage (intestinal porcine epithelial cell line (IPEC-J2)) is well illustrated by Hussain et al [ 120 ].…”

Section: Regulation Of Polyphenols In Weaning Stress Mediated By Gut Microbiotamentioning

confidence: 99%

The Role of Polyphenols in Regulation of Heat Shock Proteins and Gut Microbiota in Weaning Stress

Hussain

Wang

Murtaza

et al. 2021

Oxidative Medicine and Cellular Longevity

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Gut microbiota is the natural residents of the intestinal ecosystem which display multiple functions that provide beneficial effects on host physiology. Disturbances in gut microbiota in weaning stress are regulated by the immune system and oxidative stress-related protein pathways. Weaning stress also alters gut microbiota response, limits digestibility, and influences animal productive performance through the production of inflammatory molecules. Heat shock proteins are the molecular chaperones that perform array functions from physiological to pathological point of view and remodeling cellular stress response. As it is involved in the defense mechanism, polyphenols ensure cellular tolerance against enormous stimuli. Polyphenols are nature-blessed compounds that show their existence in plenty of amounts. Due to their wider availability and popularity, they can exert strong immunomodulatory, antioxidative, and anti-inflammatory activities. Their promising health-promoting effects have been demonstrated in different cellular and animal studies. Dietary interventions with polyphenols may alter the gut microbiome response and attenuate the weaning stress related to inflammation. Further, polyphenols elicit health-favored effects through ameliorating inflammatory processes to improve digestibility and thereby exert a protective effect on animal production. Here, in this article, we will expand the role of dietary polyphenol intervention strategies in weaning stress which perturbs gut microbiota function and also paid emphasis to heat shock proteins in gut health. This review article gives new direction to the feed industry to formulate diet containing polyphenols which would have a significant impact on animal health.

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Coix seed improves growth performance and productivity in post-weaning pigs by reducing gut pH and modulating gut microbiota

Cited by 18 publications

References 49 publications

The different dietary sugars modulate the composition of the gut microbiota in honeybee during overwintering

The different dietary sugars modulate the composition of the gut microbiota in honeybee during overwintering

A Comparison of Production Performance, Egg Quality, and Cecal Microbiota in Laying Hens Receiving Graded Levels of Vitamin B12

The Role of Polyphenols in Regulation of Heat Shock Proteins and Gut Microbiota in Weaning Stress

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