Coinfection by Strongyloides stercoralis in blood donors infected with human T-cell leukemia/lymphoma virus type 1 in São Paulo city, Brazil

Chieffi, Pedro Paulo; Chiattone, Carlos; Feltrim, E N; Alves, Rita de Cássia; Paschoalotti, Maria Aparecida

doi:10.1590/s0074-02762000000500017

Cited by 28 publications

(21 citation statements)

References 11 publications

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“…In the present study, the rate of infection with S. stercoralis was 14.3% among patients infected with HTLV-1. This result was consistent with two reports from Brazil, specifically from the Cities of São Paulo (12.1%) 15 and Salvador (15.7%) 1 .…”

Section: Conflict Of Interest Acknowledgments Financial Supportsupporting

confidence: 93%

Occurrence of strongyloidiasis among patients with HTLV-1/2 seen at the outpatient clinic of the Núcleo de Medicina Tropical, Belém, State of Pará, Brazil

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Costa

Ferreira

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Revista da Sociedade Brasileira de Medicina Tropical 46(2):241-243, Mar-Apr, 2013 http://dx.doi. org/10.1590/0037-8682-981-2013 Occurrence of strongyloidiasis among patients with HTLV-1/2 seen at the outpatient clinic of the ABSTRACT Introduction:This study investigated the occurrence of Strongyloides stercoralis infestation and coinfection with HTLV-1/2 in Belém, Brazil. Methods: S. stercoralis was investigated in stool samples obtained from individuals infected with HTLV-1/2 and their uninfected relatives. Results: The frequency of S. stercoralis was 9% (9/100), including six patients infected with HTLV-1 (14.3%), two patients infected with HTLV-2 (11.1%), and one uninfected relative. Two cases of hyperinfestation by S. stercoralis were characterized as HTLV-1. Conclusions: These results support the need for the routine investigation of S. stercoralis in patients with HTLV-1, in an attempt to prevent the development of severe forms of strongyloidiasis.

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Section: Conflict Of Interest Acknowledgments Financial Supportsupporting

confidence: 93%

Occurrence of strongyloidiasis among patients with HTLV-1/2 seen at the outpatient clinic of the Núcleo de Medicina Tropical, Belém, State of Pará, Brazil

Furtado

Costa

Ferreira

et al. 2013

Rev. Soc. Bras. Med. Trop.

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“…This is based on epidemiologic association of Strongyloides and HTLV-1 infections in Brazil, the Caribbean Islands, and Southern Japan, and from small clinical series reporting more severe disease manifestations in the presence of both infections than with either one alone [2][3][4]. The mechanism for the synergism between these two infectious agents is unclear.…”

Section: Introductionmentioning

confidence: 99%

Effect of treatment of Strongyloides infection on HTLV‐1 expression in a patient with adult T‐cell leukemia

et al. 2007

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Human T-cell leukemia virus type 1 (HTLV-1) is associated with adult T-cell leukemia-lymphoma (ATLL) in about 5% of infected individuals. Coinfection by Strongyloides stercoralis has been suggested to be a cofactor for development of ATLL. We describe a patient who presented with HTLV-1-associated chronic ATLL and Strongyloides infection. Studies of this patient's viral RNA levels demonstrated stimulation of HTLV-1 replication by Strongyloides, which resolved with anti-helminthic therapy. This case provides support for the hypothesis that Strongyloides is a cofactor for ATLL via T-cell stimulation. Am. J. Hematol. 82:929-931, 2007. V

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“…However, a growing body of literature suggests that many HTLV-1-infected individuals show chronic immunosuppression, even in the absence of malignant disease. HTLV-1-infected individuals are more susceptible to several infectious diseases, such as strongyloidiasis (1,30), Hansen's disease (11), and tuberculosis (21,25). In addition, they have reduced cutaneous delayed-type hypersensitivity responses to purified protein derivative (PPD) of Mycobacterium tuberculosis (14,23,33,36).…”

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confidence: 99%

Peripheral Blood Mononuclear Cells from Individuals Infected with Human T-Cell Lymphotropic Virus Type 1 Have a Reduced Capacity To Respond to Recall Antigens

Mascarenhas

Brodskyn

Barbosa

et al. 2006

Clin Vaccine Immunol

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Coinfection by Strongyloides stercoralis in blood donors infected with human T-cell leukemia/lymphoma virus type 1 in São Paulo city, Brazil

Cited by 28 publications

References 11 publications

Occurrence of strongyloidiasis among patients with HTLV-1/2 seen at the outpatient clinic of the Núcleo de Medicina Tropical, Belém, State of Pará, Brazil

Occurrence of strongyloidiasis among patients with HTLV-1/2 seen at the outpatient clinic of the Núcleo de Medicina Tropical, Belém, State of Pará, Brazil

Effect of treatment of Strongyloides infection on HTLV‐1 expression in a patient with adult T‐cell leukemia

Peripheral Blood Mononuclear Cells from Individuals Infected with Human T-Cell Lymphotropic Virus Type 1 Have a Reduced Capacity To Respond to Recall Antigens

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