Peripheral Blood Mononuclear Cells from Individuals Infected with Human T-Cell Lymphotropic Virus Type 1 Have a Reduced Capacity To Respond to Recall Antigens

Mascarenhas, Rita Elizabeth Moreira; Brodskyn, Cláudia; Barbosa, Gisele Peixoto; Clarêncio, Jorge; Andrade-Filho, Antônio Souza; Figueiroa, Frederico; Galvão–Castro, Bernardo; Grassi, Maria Fernanda Rios

doi:10.1128/cvi.13.5.547-552.2006

Cited by 31 publications

(28 citation statements)

References 33 publications

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“…Classically, the highest frequency and magnitude of proliferation are found in HAM/TSP [31, 32] although a lower frequency of infected asymptomatic individuals also presents similar levels of proliferation [13, 14]. …”

Section: Discussionmentioning

confidence: 99%

Human T lymphotropic virus type 1 (HTLV-1) proviral load induces activation of T-lymphocytes in asymptomatic carriers

et al. 2014

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BackgroundHigh HTLV-1 proviral load (PVL) is mainly found in infected individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). However one third of asymptomatic carriers may have high PVL.This study aimed to evaluate the impact of PVL in the activation of T lymphocytes of asymptomatic individuals infected with HTLV-1.MethodsMembrane activation markers (CD25+, CD28+, CD45RO+, CD69+, CD62L+, HLA-DR+), FoxP3+ and intracellular IFN-γ expression were evaluated on both CD4+ and CD8+ T-lymphocytes from asymptomatic carriers with PVL ≥ and < 1% of infected cells, using flow cytometry. HTLV-1 proviral load was determined using real-time PCR.ResultsAsymptomatic carriers with PVL ≥ 1% presented a higher frequency of CD4+CD25+CD45RO+ (13.2% vs. 4%, p = 0.02), CD4+HLA-DR+ (18% vs. 8.3%, p = 0.01) and CD4+IFN-γ+ (4.5%; 1%, p = 0.01) T-cells, than healthy donors. HTLV-1 PVL was directly correlated with the proportion of CD4+CD25+CD45RO+ T-cells (R = 0.7, p = 0.003). Moreover, a significant increase in the proportion of CD4 + FoxP3+ T-cells was observed in HTLV-1-infected individuals, compared to healthy donors.ConclusionHTLV-1 PVL is associated with activation of both CD4+ and CD8+ T-lymphocytes in asymptomatic individuals. Prospective studies should be conducted to evaluate whether asymptomatic individuals with higher PVL and high immune activation are more prone to developing HTLV-1-associated diseases.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2334-14-453) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Human T lymphotropic virus type 1 (HTLV-1) proviral load induces activation of T-lymphocytes in asymptomatic carriers

et al. 2014

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“…This ultimately leads to defects in TcRinduced calcium flux and cytotoxicity (60,101,102,114,146,170). The effect on T-cell function may occur in vivo, as well; peripheral blood mononuclear cells from HTLV-1-infected individuals have been shown to have a reduced response to recall antigens (95). The opposing stimulatory and inhibitory effects of HTLV-1 relate at least in part to opposing functions mediated by the p12 I protein.…”

Section: Hivmentioning

confidence: 99%

Viral Modulation of T-Cell Receptor Signaling

Jerome

2008

J Virol

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“…As a result, HTLV-1-infected individuals have an increased population of activated lymphocytes, an increased expression of proinflammatory cytokines 29 , and lower proliferative response to recall antigens 30 , which may induce an immunosuppression. These immunological abnormalities and the highest exposure to risk factors common to HTLV-1 and HPV could explain the high prevalence of HPV infection 31 .…”

Section: Discussionmentioning

confidence: 99%

“…infection among HTLV-infected and uninfected groups when women were stratified into age ranges (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35), 36-45, 46-55, and 56-65 years). Four positive cases of HPV infection (18.2%) were observed in HTLV-infected women with 46-55 years, whereas none was found in the control group at same age (p = 0.31) (data not shown).…”

Section: Ethical Considerationsmentioning

confidence: 99%

Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional study

Lôpo

Oliveira

Santana

et al. 2012

Rev. Soc. Bras. Med. Trop.

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INTRODUCTION:HTLV-1 infection increases susceptibility to other infections. Few studies have addressed the co-infection between HPV and HTLV-1 and the immune response involved in this interaction. The aim of this study was to determine the prevalence of cervical HPV infection in HTLV-1-infected women and to establish the risk factors involved in this co-infection. METHODS: A cross-sectional study was carried out in Salvador, Brazil, between September 2005 and December 2008, involving 50 HTLV-1-infected women from the HTLV Reference Center and 40 uninfected patients from gynecological clinic, both at the Bahiana School of Medicine. HPV infection was assessed using hybrid capture. HTLV-1 proviral load was quantified using real-time polymerase chain reaction (PCR). RESULTS: The mean age of HTLV-1-infected women (38 ± 10 years) was similar to that of the control group (36 ± 13 years). The prevalence of HPV infection was 44% in the HTLV-1-infected group and 22.5% in uninfected women (p = 0.03). HTLV-1-infected women had lower mean age at onset of sexual life (17 ± 3 years versus 19 ± 3 years; p = 0.03) and greater number of lifetime partners compared with the control group (4 ± 3 versus 2 ± 1; p < 0.01). In the group of HTLV-1-infected patients, there was neither difference in HTLV-1 proviral load between HPV-infected women and the uninfected. CONCLUSIONS: The prevalence of HPV infection was higher in HTLV-1-infected women. Further studies should be performed to evaluate the progression of this co-infection.

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Peripheral Blood Mononuclear Cells from Individuals Infected with Human T-Cell Lymphotropic Virus Type 1 Have a Reduced Capacity To Respond to Recall Antigens

Abstract: Evidence indicates that human T-cell lymphotropic virus type 1 (HTLV-1

Cited by 31 publications

References 33 publications

Human T lymphotropic virus type 1 (HTLV-1) proviral load induces activation of T-lymphocytes in asymptomatic carriers

Human T lymphotropic virus type 1 (HTLV-1) proviral load induces activation of T-lymphocytes in asymptomatic carriers

Viral Modulation of T-Cell Receptor Signaling

Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cross-sectional study

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