Coincidence of Adrenal Atrophy, Haemolytic Anaemia and Hyperthyroidism in a Patient Followed by Sudden Death

Klaassen, C. H. L.; Dommelen, C. K. V.; Unnik, J. A. M. van

doi:10.1111/j.0954-6820.1966.tb02837.x

Cited by 3 publications

(1 citation statement)

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“…It is widely believed that immunological disturbances participate in the pathogenesis of hyperthyroidism (5, 19,22). Hyperthyroidism is known to be associated with some other diseases thought to be immunologically induced, such as myasthenia gravis (8,18,21), Addison's disease (2,7,9,15) and pernicious anemia (20,25,28). A similar interrelationship is also illustrated by the association of Addison's disease with pernicious anemia (1,2).…”

Section: Discussionmentioning

confidence: 88%

The Thyroid in Ulcerative Colitis and Crohn's Disease

1975

Journal of Internal Medicine

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The frequency of thyroid disease has been surveyed in 300 patients with ulcerative colitis (UC) and 600 controls. The controls were drawn from visitors to the general medical wards of the Radcliffe Infirmary and were matched for age and sex with the UC patients. Two observers independently assessed all these subjects for thyroid enlargement of the simple goitre type. Although there were minor variations between the results obtained by the two observers, they found simple goitre in 8.7–6.3% among the UC patients compared with 4.3–3.3% among the controls; a difference which is significant. A history of thyrotoxicosis was obtained in 3.7% of the UC patients compared with 0.8% of the controls (p < 0.01). In more than half of the UC patients with a history of hyperthyroidism, the hyperthyroidism occurred years before the onset of the colitis. It is therefore highly unlikely that hyperthyroidism is a complication of the colitis. Possible reasons for the association of the two diseases are discussed but it is concluded that no satisfactory explanation exists at present.

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