Cohort Profile: The STRIP Study (Special Turku Coronary Risk Factor Intervention Project), an Infancy-onset Dietary and Life-style Intervention Trial

Simell, Olli; Niinikoski, Harri; Rönnemaa, Tapani; Raitakari, Olli T.; Lagström, Hanna; Laurinen, Maarit; Aromaa, Minna; Hakala, Paula; Jula, Antti; Jokinen, Eero; Välimäki, Ilkka; Viikari, Jorma

doi:10.1093/ije/dyn072

Cited by 94 publications

(135 citation statements)

References 23 publications

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“…11,12 Briefly, families of 5-month-old infants were recruited to the study at well-baby clinics in Turku, Finland, between 1990 and 1992. At age 7 months, 1062 infants were randomized to an intervention group (n=540) or to a control group (n=522).…”

Section: Design and Subjectsmentioning

confidence: 99%

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Cardiometabolic Determinants of Carotid and Aortic Distensibility From Childhood to Early Adulthood

et al. 2017

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A rterial stiffness or decreased arterial distensibility has been implicated as a predictor of cardiovascular diseases.1,2 Cardiometabolic risk factors, such as high LDL-C (low-density lipoprotein cholesterol), elevated blood pressure (BP), and obesity, have been associated with arterial stiffness in adults. 3 We have shown that exposure to cardiometabolic risk markers in childhood is associated with decreased carotid artery distensibility (cdist) in adulthood. 4 Already at early age, obese children and those with familial hypercholesterolemia have stiffer arteries compared with lean, healthy peers in a cross-sectional setting. 5,6 We have previously reported in the longitudinal STRIP (Special Turku Coronary Risk Factor Intervention Project) studying healthy children that cdist and aortic distensibility (adist) decrease from childhood to early adulthood and that boys have markedly stiffer arteries than girls. 7 The STRIP dietary intervention focused on quality of fat was not associated with arterial distensibility at this early age. 7 We have also shown that childhood exposure to tobacco smoke is associated with decreased adist at age of 11 years 8 while higher cardiorespiratory fitness and ideal cardiovascular health score associate with increased arterial distensibility in adolescence. 9,10 However, to date, in healthy children, a comprehensive, longitudinal assessment of cardiometabolic determinants of arterial distensibility from childhood to adulthood is still lacking.Therefore, we studied in the prospective STRIP cohort the association of several cardiometabolic risk markers and dietary variables with distensibility of the 2 key arteries, aorta Abstract-Children who are obese or have familial hypercholesterolemia have stiffer arteries compared with lean, healthy peers. Limited data are, however, available on the association of cardiometabolic risk markers and arterial distensibility in healthy children, particularly in a longitudinal setting. Therefore, we studied in the prospective STRIP (Special Turku Coronary Risk Factor Intervention Project) comprising healthy, predominantly normal weight participants the association of several cardiometabolic and dietary risk markers with arterial distensibility from childhood to early adulthood. Carotid and aortic distensibility (cdist, adist) was assessed repeatedly with ultrasonography at the age of 11, 13, 15, 17, and 19 years in the longitudinal atherosclerosis prevention study (n cdist =420-503, n adist =407-476 Dietary variables were not independently associated with arterial distensibility. Participants with low arterial distensibility had higher body mass index (P cdist =0.0090, P adist =0.098) and higher systolic (P cdist <0.0001, P adist <0.0001) and diastolic blood pressures (P cdist <0.0001, P adist =0.0002) already from early childhood. Body mass index, blood pressure, low-density lipoprotein cholesterol, and homeostasis model of insulin resistance identified since childhood associate with arterial distensibility in healthy children and adolescents. Thes...

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Section: Design and Subjectsmentioning

confidence: 99%

“…In the cohort, cdist and adist were measured repeatedly at the ages of 11,13,15,17, and 19 years (n cdist =420-503, n adist =407-476), along with cardiometabolic and dietary risk markers.…”

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confidence: 99%

Cardiometabolic Determinants of Carotid and Aortic Distensibility From Childhood to Early Adulthood

et al. 2017

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“…15 All participants were White. The families were randomly assigned to an intervention group (n ¼ 562 children) or to a control group (n ¼ 545 children).…”

Section: Study Design and Participantsmentioning

confidence: 99%

Longitudinal child-oriented dietary intervention: Association with parental diet and cardio-metabolic risk factors. The Special Turku Coronary Risk Factor Intervention Project

Jaakkola

Pahkala

Rönnemaa

et al. 2017

Eur J Prev Cardiolog

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Background: The child-oriented dietary intervention given in the prospective Special Turku Coronary Risk Factor Intervention Project (STRIP) has decreased the intake of saturated fat and lowered serum cholesterol concentration in children from infancy until early adulthood. In this study, we investigated whether the uniquely long-term child-oriented intervention has affected also secondarily parental diet and cardio-metabolic risk factors. Methods: The STRIP study is a longitudinal, randomized infancy-onset atherosclerosis prevention trial continued from the child's age of 8 months to 20 years. The main aim was to modify the child's diet towards reduced intake of saturated fat. Parental dietary intake assessed by a one-day food record and cardio-metabolic risk factors were analysed between the child's ages of 9-19 years. Results: Saturated fat intake of parents in the intervention group was lower [mothers: 12.0 versus 13.9 daily energy (E%), p < 0.0001; fathers: 12.5 versus 13.9 E%, p < 0.0001] and polyunsaturated fat intake was higher (mothers: 6.1 versus 5.4 E%, p < 0.0001; fathers: 6.3 versus 5.9 E%, p ¼ 0.0003) compared with the control parents. Maternal total and lowdensity lipoprotein cholesterol concentrations were lower in the intervention compared with the control group (mean AE SE 5.02 AE 0.04 versus 5.14 AE 0.04 mmol/l, p ¼ 0.04 and 3.19 AE 0.04 versus 3.30 AE 0.03 mmol/l, p ¼ 0.03, respectively). Paternal cholesterol values did not differ between the intervention and control groups. Other cardio-metabolic risk factors were similar in the study groups. Conclusions: Child-oriented dietary intervention shifted the dietary fat intakes of parents closer to the recommendations and tended to decrease total and low-density lipoprotein cholesterol in the intervention mothers. Dietary intervention directed to children benefits also parents.

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“…15,16 Briefly, families of 5-month-old infants were recruited to the study at the well-baby clinics in Turku, Finland, between February 1990 and June 1992 (extended methods, please see online-only Data Supplement). This study cohort comprised those children for whom vascular ultrasound data (distensibility) was available at ages of 11, 13, 15, 17, and 19 years.…”

Section: Design and Subjectsmentioning

confidence: 99%

Distensibility of the Aorta and Carotid Artery and Left Ventricular Mass From Childhood to Early Adulthood

et al. 2015

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Abstract-In adults, arterial distensibility decreases with age and relates to changes in cardiac left ventricular mass.Longitudinal data on changes in arterial distensibility from childhood to adulthood are lacking. Our aim was to study the effect of age and sex, and low-saturated fat dietary counseling on arterial distensibility from childhood to early adulthood. In addition, we assessed the association of arterial distensibility with left ventricular mass. Distensibility of the abdominal aorta and common carotid artery was measured repeatedly at ages 11, 13, 15, 17, and 19 years (n=395-472) in an atherosclerosis prevention trial (Special Turku Coronary Risk Factor Intervention Project [STRIP]). Aortic and carotid distensibility decreased with age (both P<0.0001). In boys, distensibility values were generally lower (P<0.0001) and showed steeper decrease by age (age and sex interaction: both P<0.01). The low-saturated fat dietary counseling given in STRIP was not significantly associated with arterial distensibility. Left ventricular mass increased with age (P<0.0001), and it was greater in boys (P<0.0001). In conclusion, a marked age-related decrease in vascular distensibility was found already at this young age, and this decrease was more pronounced in boys than girls. The longitudinal progression of aortic and carotid distensibility was related with changes in left ventricular mass. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: NCT00223600.

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Cohort Profile: The STRIP Study (Special Turku Coronary Risk Factor Intervention Project), an Infancy-onset Dietary and Life-style Intervention Trial

Cited by 94 publications

References 23 publications

Cardiometabolic Determinants of Carotid and Aortic Distensibility From Childhood to Early Adulthood

Cardiometabolic Determinants of Carotid and Aortic Distensibility From Childhood to Early Adulthood

Longitudinal child-oriented dietary intervention: Association with parental diet and cardio-metabolic risk factors. The Special Turku Coronary Risk Factor Intervention Project

Distensibility of the Aorta and Carotid Artery and Left Ventricular Mass From Childhood to Early Adulthood

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