Cohort Profile: The Golestan Cohort Study--a prospective study of oesophageal cancer in northern Iran

Pourshams, Akram; Khademi, Hooman; Malekshah, Akbar Fazeltabar; Islami, Farhad; Nouraei, Mehdi; Sadjadi, Alireza; Jafari, Elham; Rakhshani, Naser; Salahi, Rasool; Semnani, Shahryar; Kamangar, Farin; Abnet, Christian C.; Ponder, Bruce A.J.; Day, Nick; Dawsey, Sanford M.; Boffetta, Paolo; Malekzadeh, Reza

doi:10.1093/ije/dyp161

Cited by 205 publications

(278 citation statements)

References 16 publications

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“…Study participants were selected using random sampling of persons without a history of upper gastrointestinal cancer who lived in Gonbad City and 326 villages in Golestan Province. Further details have been provided elsewhere (32). Our analyses included men and women who completed a food frequency questionnaire (n = 49,112) at baseline.…”

Section: Study Populationmentioning

confidence: 99%

Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality

Farvid¹,

Malekshah²,

Pourshams³

et al. 2017

American Journal of Epidemiology

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We investigated the association between dairy product consumption and all-cause, cardiovascular disease (CVD), and cancer mortality in the Golestan Cohort Study, a prospective cohort study launched in January 2004 in Golestan Province, northeastern Iran. A total of 42,403 men and women participated in the study and completed a diet questionnaire at enrollment. Cox proportional hazards models were used to estimate hazard ratios and 95% confidence intervals. We documented 3,291 deaths (1,467 from CVD and 859 from cancer) during 11 years of follow-up (2004-2015). The highest quintile of total dairy product consumption (versus the lowest) was associated with 19% lower all-cause mortality risk (hazard ratio (HR) = 0.81, 95% confidence interval (CI): 0.72, 0.91; P trend = 0.006) and 28% lower CVD mortality risk (HR = 0.72, 95% CI: 0.60, 0.86; P trend = 0.005). High consumption of low-fat dairy food was associated with lower risk of all-cause (HR = 0.83, 95% CI: 0.73, 0.94; P trend = 0.002) and CVD (HR = 0.74, 95% CI: 0.61, 0.89; P trend = 0.001) mortality. We noted 11% lower all-cause mortality and 16% lower CVD mortality risk with high yogurt intake. Cheese intake was associated with 16% lower all-cause mortality and 26% lower CVD mortality risk. Higher intake of high-fat dairy food and milk was not associated with all-cause or CVD mortality. Neither intake of individual dairy products nor intake of total dairy products was significantly associated with overall cancer mortality. High consumption of dairy products, especially yogurt and cheese, may reduce the risk of overall and CVD mortality.

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Section: Study Populationmentioning

confidence: 99%

Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality

Farvid¹,

Malekshah²,

Pourshams³

et al. 2017

American Journal of Epidemiology

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“…This report is based on one of several studies on gastric and esophageal cancers (Islami et al 2004;Pourshams et al 2010;Sadjadi et al 2003) which is underway in Gonbad, the second largest city of Golestan province, in northeastern Iran and in Ardabil, the largest city in Ardabil province in northwestern Iran. Turkmens constitute half of the population in Golestan province, and Persians, Turks, Sistanies, Balouches, and Kurds constitute the other half (referred to here as non-Turkmens).…”

Section: Study Subjectsmentioning

confidence: 99%

Mutations in Fanconi anemia genes and the risk of esophageal cancer

et al. 2011

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The incidence of esophageal squamous cell carcinoma (ESCC) is very high in northeastern Iran. Previously, we reported a strong familial component of ESCC among Turkmens, who constitute approximately one-half of the population of this region. We hypothesized that the genes which cause Fanconi anemia might be candidate genes for ESCC. We sequenced the entire coding regions of 12 Fanconi anemia genes in the germline DNA of 190 Turkmen cases of ESCC. We identified three heterozygous insertion/deletion mutations: one in FANCD2 (p.Val1233del), one in FANCE (p.Val311SerfsX2), and one in FANCL (p.Thr367AsnfsX13). All three patients had a strong family history of ESCC. In addition, four patients (out of 746 tested) were homozygous for the FANCA p.Ser858Arg mutation, compared to none of 1,373 matched controls (OR = 16.7, 95% CI = 6.2-44.2, P = 0.01). The p. Lys3326X mutation in BRCA2 (also known as Fanconi anemia gene FANCD1) was present in 27 of 746 ESCC cases and in 16 of 1,373 controls (OR = 3.38, 95% CI = 1.97-6.91, P = 0.0002). In summary, both heterozygous and homozygous mutations in several Fanconi anemia-predisposing genes are associated with an increased risk of ESCC in Iran.

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“…Rashidkhani et al reported that a history of reflux symptoms was shown to be a risk factor for esophageal cancer (41). In a cohort study carried out by Pourshams et al in northeast Iran, complaints of gastric esophageal reflux disease were widespread in the participants during the preparatory phase, and 31% of them complained of this problem at least once a week (42). The role of weekly symptoms of gastroesophageal acid reflux has also been confirmed as one of the major causes of esophageal cancer in northwest Iran (Ardabil) (43).…”

Section: Discussionmentioning

confidence: 99%

Study of Risk Factors for Esophageal Cancer in Khorramabad City From 2012 - 2014

Shamsifar

Sepahvand

Rezapour

et al. 2016

Jundishapur J Chronic Dis Care

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Background: Esophageal cancer is of major concern worldwide, ranking sixth as the most common cause of cancer mortality. Lifestyles such as cigarette smoking, alcohol consumption, and poor dietary habits have been suggested to be associated with the carcinogenesis of esophageal cancer. Objectives: This study aimed to determine the factors affecting and associated with esophageal cancer in Khorramabad city from 2012 to 2014. Patients and Methods: This is an analytical study of 48 patients with esophageal cancer, including 80 controls. The patients were selected on the basis of a census. The data were collected using a questionnaire, and Chi-square, t-test, and one way ANOVA analyses were performed using SPSS 19. Results: In this study, 57.8% males and 42.2% females participated, while the mean age of the patients was 68.46 years old, and the mean age of the healthy individuals was 59.79 years old. The findings of this study showed a family history of cancer, anemia, and smoking, and associations with education, occupation, socioeconomic status, blood group, consumption of hot drinks, as well as a history of gastroesophageal reflux. In addition, there was a significant relationship, but no significant association, between alcohol consumption and esophageal cancer. Conclusions: According to the results of this study, the necessary measures to modify the risk factors, such as educational programs and changing food consumption patterns in the subjects, are effective, and can reduce the risk of esophageal cancer.

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Cohort Profile: The Golestan Cohort Study--a prospective study of oesophageal cancer in northern Iran

Cited by 205 publications

References 16 publications

Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality

Dairy Food Intake and All-Cause, Cardiovascular Disease, and Cancer Mortality

Mutations in Fanconi anemia genes and the risk of esophageal cancer

Study of Risk Factors for Esophageal Cancer in Khorramabad City From 2012 - 2014

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