Cohort Profile: The China Hainan Centenarian Cohort Study (CHCCS)

He, Yao; Zhao, Yali; Yao, Yao; Yang, Shanshan; Li, Jing; Liu, Miaomiao; Chen, Xiaoping; Wang, Jianhua; Zhu, Qiao; Li, Xiaoying; Zhang, Fu; Luan, Fuxin

doi:10.1093/ije/dyy017

Cited by 68 publications

(59 citation statements)

References 32 publications

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“…The survey included a representative sample of the individuals aged between 80-99 years old and centenarians (>100 years old) in Hainan Province. Details of the sampling strategy for centenarians were described in other studies (13,14). For the individuals aged between 80-99, stratified random sampling was adopted.…”

Section: Study Design and Study Populationmentioning

confidence: 99%

Health-Related Quality of Life and Associated Factors Among Oldest-Old in China

Chen

Liu

Shi

et al. 2020

The Journal of nutrition, health and aging

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Objectives: The oldest old population has become the fastest growing segment with excess need of care and social support, it is crucial to improve the health-related quality of life (HRQoL) of these populations. This study seeks to evaluate the health status and to investigate modifiable factors associated with health-related quality of life for oldest old adults in China. Design: A cross-sectional population-based study. Setting: Hainan Province in the south of China. Participants: 1,278 adults aged 80 years or older. Methods: HRQoL was assessed by three-level EuroQol-5D scale (EQ-5D-3L) and a visual analogue scale (VAS). Demographic and healthrelated variables were analysed by estimating mean values and standard deviations for continuous variables, percentages and standard deviations for categorical variables. Tobit regressions, ordinary least Squared (OLS) regressions and ordered probit regressions were adopted to determine the associated factors for overall HRQoL and for each health dimension. Results: Anxiety/depression was the least reported problem while mobility was the most frequently reported with problem. Female respondents had lower EQ-5D score (0.76 vs. 0.86) and VAS score (66.55 vs. 69.84) than male respondents. Better health-related quality of life was significantly associated with higher BMI, no drinking habit, more leisure activities, living with family members, good sleeping quality, closer social and family connections, fewer numbers of drugs consumed per day, without having hearing or visual impairment, and fewer chronic conditions, after controlling for potential confounders. Conclusion: Findings from this study suggested that quality of life was not only associated with age-related diseases, but also correlated with a range of health-related lifestyles, and factors indicating social and family support.

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Section: Study Design and Study Populationmentioning

confidence: 99%

Health-Related Quality of Life and Associated Factors Among Oldest-Old in China

Chen

Liu

Shi

et al. 2020

The Journal of nutrition, health and aging

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“…The design, implementation and methods of CHCCS have been reported previously. 7 Briefly, all participants and their relatives were aware of the planned study and the criteria for inclusion and exclusion. The baseline survey included field questionnaire survey, physical/clinical examination and biological specimen collection, and finally included 1002 participants (18.0% male, 82.0% female).…”

Section: Study Populationmentioning

confidence: 99%

“…There were three rounds for age validation process to avoid participants from exaggerating their age. 7 Then clinical examinations, including the measurement of blood pressure, anthropometric indices, were conducted by the specialized group consisting of experienced geriatricians and trained nurses from the Hainan Branch of the Chinese PLA General Hospital. The blood pressure was measured by an electronic sphygmomanometer (1mmHg = 0.133 kPa) with an accuracy of 1 mmHg, which should be measured twice, and repeated measurement should be made at intervals of 1-2 mins.…”

Section: Other Measurementmentioning

confidence: 99%

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<p>Higher Normal Levels of Triglyceride and Low and High-Density Lipoprotein Cholesterol Might Have a Protective Effect Against Activities of Daily Living Disability Within Chinese Female Centenarians: A Cross-Sectional, Complete Sample Study</p>

Wang¹,

Liu²,

Yang³

et al. 2020

CIA

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Background and Objective: Activities of daily living (ADL) disability seriously affects the quality of life in the elderly. This study aims to examine the prevalence of ADL disability and its possible correlation with lipid profile indicators (LDL-C, TG and HDL-C) among female centenarians in Hainan, China. Methods: A cross-section of complete sample study including 822 female centenarians was conducted from the China Hainan Centenarians Cohort Study (CHCCS) from June 2014 to December 2016. Barthel index was used to estimate ADL disability and multivariate logistic regression model was used to explore the relationship between lipid profile indicator and ADL disability. Results: A total of 822 female centenarians were recruited in Hainan province, and the median age was 102 (IQR: 101-104) years, and 244 (29.7%) centenarians had ADL disability. After adjustment, 1 mmol/L increment in LDL-C, TG and HDL-C were associated with 26.4% (aOR=0.736, 95% CI:0.592-0.915), 29.8% (aOR=0.702, 95% CI:0.521-0.948) and 60.5% (aOR=0.395, 95% CI:0.257-0.610) decline in ADL disability of female centenarian, respectively. The prevalence of ADL disability showed downward trend with the increase of the quintile of LDL-C, TG and HDL-C (P trend <0.05). Increment of HDL-C levels had the strongest protective effect against ADL disability. Conclusion: We concluded that a new possible association of higher normal lipid profile indicators, especially HDL-C, might have a protective effect on ADL disability among female centenarians.

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“…We assessed cross-sectional data collected from 2014-2016 in the China Hainan Centenarian Cohort Study (CHCCS) [20], a longitudinal observational study that targeted the population aged 100 years or older in Hainan, China. The CHCCS is based on a complete sample of the Hainan community-dwelling and institutionalized centenarian population conducted by an interdisciplinary research team.…”

Section: Study Populationmentioning

confidence: 99%

Serum Albumin and Activities of Daily Living in Chinese Centenarians: A Cross-Sectional Study

Han

Wang

Jia

et al. 2020

Preprint

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Abstract Background Objective deterioration in activities of daily living (ADLs) exists among older people, and particularly worsens with age. Considering the criterion standard of positive aging and longevity, little information focusing on centenarians is available. The present study aimed to examine the relationship between serum albumin and ADLs among centenarians in long-lived areas. Methods This population-based cross-sectional study investigated a complete sample of Chinese persons aged ≥100 years in Hainan, the longest-lived area of China (n=1002). We assessed serum albumin levels and basic and instrumental activities of daily living (BADLs and IADLs). Results Of 1002 participants included in the analysis, 287 (28.64%) had BADL disabilities and 648 (64.67%) had IADL disabilities. The median serum albumin level was 38.5 g/L (interquartile range, 36.2–41.3). The multivariable analyses controlling for socio-demographic characteristics, lifestyle, morbidities, and other influential factors showed that albumin level was associated with the total score of BADL ( standard β=0.335, P<0.001) and IADL ( standard β=0.206, P<0.001). With the increasing of albumin level, the risk of ADLs disability decreased (BADL: odds ratios [OR] = 0.835, 95% Confidence interval [CI]: 0.797-0.876; IADL: OR=0.863, 95%CI: 0.824-0.905). In the stratified analyses, similar results were found in both sex, but were more prominent in women. Conclusions Higher levels of serum albumin was a protective factor for the decline of ADLs in centenarians. This association can be observed in both genders and is more pronounced in women.

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Cohort Profile: The China Hainan Centenarian Cohort Study (CHCCS)

Cited by 68 publications

References 32 publications

Health-Related Quality of Life and Associated Factors Among Oldest-Old in China

Health-Related Quality of Life and Associated Factors Among Oldest-Old in China

<p>Higher Normal Levels of Triglyceride and Low and High-Density Lipoprotein Cholesterol Might Have a Protective Effect Against Activities of Daily Living Disability Within Chinese Female Centenarians: A Cross-Sectional, Complete Sample Study</p>

Serum Albumin and Activities of Daily Living in Chinese Centenarians: A Cross-Sectional Study

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