<p>Higher Normal Levels of Triglyceride and Low and High-Density Lipoprotein Cholesterol Might Have a Protective Effect Against Activities of Daily Living Disability Within Chinese Female Centenarians: A Cross-Sectional, Complete Sample Study</p>

Abstract

Background and Objective: Activities of daily living (ADL) disability seriously affects the quality of life in the elderly. This study aims to examine the prevalence of ADL disability and its possible correlation with lipid profile indicators (LDL-C, TG and HDL-C) among female centenarians in Hainan, China. Methods: A cross-section of complete sample study including 822 female centenarians was conducted from the China Hainan Centenarians Cohort Study (CHCCS) from June 2014 to December 2016. Barthel index was used to estimate ADL disability and multivariate logistic regression model was used to explore the relationship between lipid profile indicator and ADL disability. Results: A total of 822 female centenarians were recruited in Hainan province, and the median age was 102 (IQR: 101-104) years, and 244 (29.7%) centenarians had ADL disability. After adjustment, 1 mmol/L increment in LDL-C, TG and HDL-C were associated with 26.4% (aOR=0.736, 95% CI:0.592-0.915), 29.8% (aOR=0.702, 95% CI:0.521-0.948) and 60.5% (aOR=0.395, 95% CI:0.257-0.610) decline in ADL disability of female centenarian, respectively. The prevalence of ADL disability showed downward trend with the increase of the quintile of LDL-C, TG and HDL-C (P trend <0.05). Increment of HDL-C levels had the strongest protective effect against ADL disability. Conclusion: We concluded that a new possible association of higher normal lipid profile indicators, especially HDL-C, might have a protective effect on ADL disability among female centenarians.

Analyzing Successful Aging and Longevity: Risk Factors and Health Promoters in 2020 Older Adults

“…Reduced high-density lipoprotein levels were also associated with three GSs, including impaired cognitive function, dependence ADL, and frailty. Other studies have also confirmed that increased levels of high-density lipoproteins have an additional protective effect against dependence in ADL [59]. Notably, no association was found between the GSs and low-density lipoproteins.…”

The Role of BMI and Blood Pressure in the Relationship Between Total Cholesterol and Disability in Chinese Centenarians: A Cross-Sectional Study

“…However, in an older population, there is no consensus concerning the health impact of hypercholesterolemia on longevity and disability. Studies have shown that higher triglyceride may be related to better ADL among the older population ( 10 , 11 ), and even higher lipid profiles are beneficial to longevity and functional performance among the older population ( 12 – 15 ). In addition, the influence pathway and physiological mechanism of the possible effect of blood lipids on disability were complex and uncertain.…”