Cognitive Training and Noninvasive Brain Stimulation for Cognition in Parkinson’s Disease: A Meta-analysis

Lawrence, Blake J.; Gasson, Natalie; Bucks, Romola S.; Troeung, Lakkhina; Loftus, Andrea M.

doi:10.1177/1545968317712468

Cited by 60 publications

(62 citation statements)

References 65 publications

(170 reference statements)

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“…One of these reviews included people with dementia living in long-term care facilities (Folkerts et al, 2017). Two reviews focused on PD (Lawrence, Gasson, Bucks, Troeung, & Loftus, 2017;Leung et al, 2015) and four on individuals with stroke (das Nair, Cogger, Worthington, & Lincoln, 2016;Loetscher & Lincoln, 2013;Rogers, Foord, Stolwyk, Wong, & Wilson, 2018;Virk, Williams, Brunsdon, Suh, & Morrow, 2015). Five reviews were classified as a mixed population, three included individuals with MCI and dementia (Hoefler, 2016;Kurz, Leucht, & Lautenschlager, 2011;Yang et al, 2018), one stated that they looked at participants without dementia (Floyd & Scogin, 1997) and one did not specify cognitive status (Pinquart & Sörensen, 2001).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Cognition-Oriented Treatments for Older Adults: a Systematic Overview of Systematic Reviews

et al. 2020

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Cognition-oriented treatmentscommonly categorized as cognitive training, cognitive rehabilitation and cognitive stimulationare promising approaches for the prevention of cognitive and functional decline in older adults. We conducted a systematic overview of meta-analyses investigating the efficacy of cognition-oriented treatments on cognitive and non-cognitive outcomes in older adults with or without cognitive impairment. Review quality was assessed by A Measurement Tool to Assess Systematic Reviews 2 (AMSTAR). We identified 51 eligible reviews, 46 of which were included in the quantitative synthesis. The confidence ratings were "moderate" for 9 (20%), "low" for 13 (28%) and "critically low" for 24 (52%) of the 46 reviews. While most reviews provided pooled effect estimates for objective cognition, non-cognitive outcomes of potential relevance were more sparsely reported. The mean effect estimate on cognition was small for cognitive training in healthy older adults (mean Hedges' g = 0.32, range 0.13-0.64, 19 reviews), mild cognitive impairment (mean Hedges' g = 0.40, range 0.32-0.60, five reviews), and dementia (mean Hedges' g = 0.38, range 0.09-1.16, seven reviews), and small for cognitive stimulation in dementia (mean Hedges' g = 0.36, range 0.26-0.44, five reviews). Meta-regression revealed that higher AMSTAR score was associated with larger effect estimates for cognitive outcomes. The available evidence supports the efficacy of cognition-oriented treatments improving cognitive performance in older adults. The extent to which such effects are of clinical value remains unclear, due to the scarcity of high-quality evidence and heterogeneity in reported findings. An important avenue for future trials is to include relevant non-cognitive outcomes in a more consistent way and, for meta-analyses in the field, there is a need for better adherence to methodological standards. PROSPERO registration number: CRD42018084490.

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Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Two reviews assessed the effects of cognitive training in PD (Lawrence et al, 2017;Leung et al, 2015), both showed a small and significant interventional effect on cognitive outcomes.…”

Section: Cognitive Outcomesmentioning

confidence: 99%

Cognition-Oriented Treatments for Older Adults: a Systematic Overview of Systematic Reviews

et al. 2020

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“…Two reviews assessed the effects of CT in PD (Lawrence et al, 2017;I. H. Leung et al, 2015), both showed a small and significant interventional effect on cognitive outcomes.…”

Section: Cognitive Outcomesmentioning

confidence: 99%

Cognition-oriented treatments for older adults: A systematic overview of systematic reviews

Gavelin¹,

Lampit²,

Hallock³

et al. 2019

Preprint

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Cognition-oriented treatments (COTs) -commonly categorized as cognitive training, cognitive rehabilitation and cognitive stimulation -are promising approaches for the prevention of cognitive and functional decline in older adults. We conducted a systematic overview of meta-analyses investigating the efficacy of COTs on cognitive and non-cognitive outcomes in older adults with or without cognitive impairment. Review quality was assessed by AMSTAR 2. We identified 51 eligible reviews, 46 of which were included in the quantitative synthesis. The confidence ratings were "moderate" for 9 (20%), "low" for 13 (28%) and "critically low" for 24 (52%) of the 46 reviews. While most reviews provided pooled effect estimates for objective cognition, non-cognitive outcomes of potential relevance were more sparsely reported. The mean effect estimate on cognition was small for cognitive training in healthy older adults (Hedge's g 0.32, range 0.13-0.64, 19 reviews), mild cognitive impairment (Hedge's g 0.40, range 0.32-0.60, five reviews), and dementia (Hedge's g 0.38, range 0.09-1.16, seven reviews), and small for cognitive stimulation in dementia (Hedge's g 0.36, range 0.26-0.44, five reviews). Meta-regression revealed that higher AMSTAR score was associated with larger effect estimates for cognitive outcomes. The available evidence supports the efficacy of COTs improving cognitive performance in older adults. The extent to which such effects are of clinical value remains unclear, due to the scarcity of high-quality evidence and heterogeneity in reported findings. An important avenue for future trials is to include relevant non-cognitive outcomes in a more consistent way and, for meta-analyses in the field, there is a need for better adherence to methodological standards. PROSPERO registration number: CRD42018084490.

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“…Numerous investigations have proved that the aberrant spontaneous neural activity and functional networks of several diseases could be modulated by using repetitive transcranial magnetic stimulation (rTMS) through changing the excitability of the site of stimulation as well as the distant anatomically connected sites [16][17][18][19][20][21][22]. Previous rTMS studies on patients with cognition impairment in Alzheimer's disease, Parkinson's disease, schizophrenia, and dementia in older patients have reported significant positive effectiveness on improving cognitive ability [23][24][25][26]. Similar results were reported in both animal and human studies on SD which also observed the potential effectiveness of rTMS for the treatment of cognitive impairment induced by SD, especially the working memory [27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

High-Frequency Repetitive Transcranial Magnetic Stimulation Could Improve Impaired Working Memory Induced by Sleep Deprivation

Jiang

McClure

et al. 2019

Neural Plasticity

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Objective. To investigate whether and how the working memory impairment induced by sleep deprivation (SD) could be recovered by using repetitive transcranial magnetic stimulation (rTMS), as well as to clarify the corresponding brain activity changes. Methods. Seventeen healthy adults received one session of 5.0 Hz rTMS over the left dorsolateral prefrontal cortex (DLPFC) following 24 hours of SD. Resting state functional magnetic resonance imaging (fMRI) and working memory test were performed during a rested waking period, after SD and rTMS. The amplitude of low-frequency fluctuations (ALFF) was used to detect the spontaneous neural activity changes after both SD and rTMS. The relationship between ALFF and the performance of working memory was also assessed by using correlation analysis. Results. After SD, the participants exhibited lower response accuracies and longer reaction times on the working memory tests of letters and numbers. The decreased response accuracy of numbers was significantly improved after rTMS similarly to the state of the rested waking period after a normal night of sleep. ALFF values decreased from the rested waking period state to the state of SD in the brain regions involving the frontal gyrus, precuneus, angular gyrus, and parietal lobe which showed significantly increased ALFF after rTMS. Furthermore, significantly positive correlations were observed between changes of response accuracy and the changes of ALFF value of the inferior frontal gyrus and supramarginal gyrus. Conclusion. These results indicate that high-frequency rTMS applied over left DLPFC may contribute to the recovery of the impaired working memory after SD by modulating the neural activity of related brain regions.

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Cognitive Training and Noninvasive Brain Stimulation for Cognition in Parkinson’s Disease: A Meta-analysis

Abstract: The results suggest that standard and tailored cognitive training may improve executive function, attention/working memory, and memory in PD. Future studies must adopt randomized controlled trial designs to explore the therapeutic potential of these interventions.

Cited by 60 publications

References 65 publications

Cognition-Oriented Treatments for Older Adults: a Systematic Overview of Systematic Reviews

Cognition-Oriented Treatments for Older Adults: a Systematic Overview of Systematic Reviews

Cognition-oriented treatments for older adults: A systematic overview of systematic reviews

High-Frequency Repetitive Transcranial Magnetic Stimulation Could Improve Impaired Working Memory Induced by Sleep Deprivation

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