Cognitive sequelae of methanol poisoning involve executive dysfunction and memory impairment in cross-sectional and long-term perspective

Bezdíček, Ondřej; Michalec, J.; Vaněčková, Manuela; Klempíř, Jiří; Lišková, Irena; Seidl, Zdeněk; Janíková, Barbara; Miovský, Michal; Hubacek, Jaroslav A.; Diblik, Pavel; Kuthan, Pavel; Pilín, A; Kurcová, Ivana; Fenclová, Zdeňka; Petrik, Vit; Navrátil, Tomáš; Pelclová, Daniela; Zakharov, Sergey; Růžička, Evžen

doi:10.1016/j.alcohol.2016.12.003

Cited by 23 publications

(16 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our previously published study, we analyzed the prevalence and predisposing factors of brain damage and hemorrhages in survivors of acute methanol poisoning [15, 37, 38]. This group included 34 patients treated with RRT from the present study.…”

Section: Discussionmentioning

confidence: 99%

Intermittent versus continuous renal replacement therapy in acute methanol poisoning: comparison of clinical effectiveness in mass poisoning outbreaks

Zakharov

Rulíšek

Nurieva

et al. 2017

Ann. Intensive Care

View full text Add to dashboard Cite

BackgroundIntermittent hemodialysis (IHD) is the modality of choice in the extracorporeal treatment (ECTR) of acute methanol poisoning. However, the comparative clinical effectiveness of intermittent versus continuous modalities (CRRT) is unknown. During an outbreak of mass methanol poisoning, we therefore studied the effect of IHD versus CRRT on mortality and the prevalence of visual/central nervous system (CNS) sequelae in survivors.MethodsThe study was designed as prospective observational cohort study. Patients hospitalized with a diagnosis of acute methanol poisoning were identified for the study. Exploratory factor analysis and multivariate logistic regression were applied to determine the effect of ECTR modality on the outcome.ResultsData were obtained from 41 patients treated with IHD and 40 patients with CRRT. The follow-up time in survivors was two years. Both groups of patients were comparable by age, time to presentation, laboratory data, clinical features, and other treatment applied. The CRRT group was more acidemic (arterial blood pH 6.96 ± 0.08 vs. 7.17 ± 0.07; p < 0.001) and more severely poisoned (25/40 vs. 9/41 patients with Glasgow Coma Scale (GCS) ≤ 8; p < 0.001). The median intensive care unit length of stay (4 (range 1–16) days vs. 4 (1–22) days; p = 0.703) and the number of patients with complications during the treatment (11/41 vs. 13/40 patients; p = 0.576) did not differ between the groups. The mortality was higher in the CRRT group (15/40 vs. 5/41; p = 0.008). The number of survivors without sequelae of poisoning was higher in the IHD group (23/41 vs. 10/40; p = 0.004). There was a significant association of ECTR modality with both mortality and the number of survivors with visual and CNS sequelae of poisoning, but this association was not present after adjustment for arterial blood pH and GCS on admission (all p > 0.05).ConclusionsIn spite of the faster correction of the acidosis and the quicker removal of the toxic metabolite in intermittent dialysis, we did not find significant differences in the treatment outcomes between the two groups after adjusting for the degree of acidemia and the severity of poisoning on admission. These findings support the strategy of “use what you have” in situations with large outbreaks and limited dialysis capacity.

show abstract

Section: Discussionmentioning

confidence: 99%

Intermittent versus continuous renal replacement therapy in acute methanol poisoning: comparison of clinical effectiveness in mass poisoning outbreaks

Zakharov

Rulíšek

Nurieva

et al. 2017

Ann. Intensive Care

View full text Add to dashboard Cite

show abstract

“…The remaining 30 surviving patients refused to participate in the study. Forty‐six patients were examined using the same protocol 2 years later in a follow‐up assessment in 2015 (Bezdicek et al., ). In the present study, a total of 43 patients with methanol poisoning were examined using the same protocol as above, 42 of which were part of the 2013 sample (total attrition 16%).…”

Section: Methodsmentioning

confidence: 99%

“…The present study is a part of the multidisciplinary project commenced in 2013 in reaction to mass methanol poisoning in the Czech Republic (Zakharov et al., ). The previous studies showed that patients performed worse than matched healthy controls on tests of several executive functions (conceptualization, mental flexibility, programming, and sensitivity to interference), explicit verbal memory (learning, immediate recall, and delayed recognition), and motor speed (Bezdicek et al, , ). In survivors of methanol poisoning, there is an association between the presence of bilateral symmetrical lesions in putamen and explicit verbal recognition memory, as well as between the presence of lesions in globus pallidus and sustained visual attention (Bezdicek et al., ).…”

mentioning

confidence: 96%

“…The previous studies showed that patients performed worse than matched healthy controls on tests of several executive functions (conceptualization, mental flexibility, programming, and sensitivity to interference), explicit verbal memory (learning, immediate recall, and delayed recognition), and motor speed (Bezdicek et al, , ). In survivors of methanol poisoning, there is an association between the presence of bilateral symmetrical lesions in putamen and explicit verbal recognition memory, as well as between the presence of lesions in globus pallidus and sustained visual attention (Bezdicek et al., ). In the present study, we extend these findings via cross‐sectional follow‐up that correlates quantitatively derived volumes of chosen brain structures (regions of interest, ROIs) with performance on cognitive tests in the same longitudinally followed sample of survivors of methanol poisoning.…”

mentioning

confidence: 96%

See 1 more Smart Citation

Methanol Poisoning as an Acute Toxicological Basal Ganglia Lesion Model: Evidence from Brain Volumetry and Cognition

Mana

Vaněčková

Klempíř

et al. 2019

Alcoholism Clin & Exp Res

View full text Add to dashboard Cite

Background: Acute methanol poisoning leads to optic neuropathy and necrotic lesions of basal ganglia (BG) and subcortical white matter. Survivors of methanol poisoning exhibit long-term executive and memory deficits. Associations between brain volumetry parameters and cognitive sequelae of methanol poisoning are not known. The aim of our study was to identify long-term associations between the cognitive performance of survivors of methanol poisoning and the volume of the brain structures that are selectively vulnerable to methanol.Methods: We conducted a cross-sectional follow-up study on a sample of patients (n = 33, age 50 AE 14 years, 82% males) who survived acute methanol poisoning during methanol mass poisoning outbreak from September 2012 till January 2013 in the Czech Republic. A battery of neuropsychological tests and brain magnetic resonance imaging were included in the clinical examination protocol. Specific brain structures (putamen, globus pallidus, nucleus caudatus, and frontal white matter) were selected as regions of interest, and their volumes were estimated using the MorphoBox prototype software.Results: In robust multiple regression models, sustained visual attention performance (as assessed by Trail Making Test and Prague Stroop Test) was positively associated with BG structures and frontal white matter volumes (Wald = 9.03 to 85.50, p < 0.01), sensitivity to interference (as assessed by Frontal Battery Assessment) was negatively associated with frontal white matter volume (Wald = 35.44 to 42.25, p < 0.001), and motor performance (as assessed by Finger Tapping Test) was positively associated with globus pallidus and frontal white matter volumes (Wald = 9.66 to 13.29, p < 0.01).Conclusions: Our results demonstrate that smaller volumes of elements of BG-thalamocortical circuitry, namely the BG and frontal white matter, relate to attention and motor performance in methanol poisoning from a long-term perspective. Disruption of those functional circuits may underlie specific cognitive deficits observed in methanol poisoning.

show abstract

“…Major consequences of non-fatal methanol poisoning include impaired vision, neurological impairments, or brain damage, mostly irreversible (Paasma, Hovda, & Jacobsen, 2009). A recent study has also shown cognitive impairments among methanol poisoning survivors (Bezdicek et al, 2017).…”

mentioning

confidence: 99%

“It can’t happen to me”

Běláčková

Janíková

Vacek

et al. 2017

Nordic Studies on Alcohol and Drugs

View full text Add to dashboard Cite

Background: In September 2012, a series of methanol poisonings occurred in the Czech Republic as a result of an influx of illicit alcohol into (predominantly) cheap alcoholic beverages on the retail market. The public authorities decided to prevent public health risks by prohibiting sales of liquors that contained more than 20% alcohol (> 20% liquor). The "partial" prohibition lasted for almost two weeks, but the poisonings still continued. This article assesses the impact of the methanol

show abstract

Cognitive sequelae of methanol poisoning involve executive dysfunction and memory impairment in cross-sectional and long-term perspective

Cited by 23 publications

References 42 publications

Intermittent versus continuous renal replacement therapy in acute methanol poisoning: comparison of clinical effectiveness in mass poisoning outbreaks

Intermittent versus continuous renal replacement therapy in acute methanol poisoning: comparison of clinical effectiveness in mass poisoning outbreaks

Methanol Poisoning as an Acute Toxicological Basal Ganglia Lesion Model: Evidence from Brain Volumetry and Cognition

“It can’t happen to me”

Contact Info

Product

Resources

About