Cognitive remediation and occupational outcome in schizophrenia spectrum disorders: A 2 year follow-up study

Lystad, June Ullevoldsæter; Falkum, Erik; Haaland, Vegard Øksendal; Bull, Helen; Evensen, Stig; McGurk, Susan R.; Ueland, Torill

doi:10.1016/j.schres.2016.12.020

Cited by 27 publications

(39 citation statements)

References 56 publications

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“…Recently, a study of the effects of cognitive remediation therapy on cognitive outcomes, assessed by the Norwegian MCCB, in schizophrenia spectrum disorders was conducted (Lystad et al, 2017). Verbal learning was the domain most improved after the intervention, replicating findings from international studies (McGurk et al, 2009;Christensen et al, 2014).…”

Section: Discussionmentioning

confidence: 59%

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Details of attention and learning change in first-episode schizophrenia

Mohn

Torgalsbøen

2018

Psychiatry Research

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Impaired attention and learning functions are common in schizophrenia. The details of this impairment, and how these change across time, are not well known. We aimed to compare the parameters of well-known attention and learning neuropsychological tests in first-episode schizophrenia (FES) patients and healthy controls in a 2-year follow-up period. The performance of 28-25 FES patients and pairwise matched healthy controls on the Continuous Performance Test-Identical Pairs, the revised Hopkins Verbal Learning Test, and the revised Brief Visuospatial Memory Test was compared at baseline and 2 years later. The attention dysfunction of the FES group was driven by slow reaction time and a comparative failure to identify correct hits. The reaction time was reduced somewhat across time in the patient group. Regarding the learning tasks, both groups increased their number of correct answers across trials. However, at each trial, the patient group exhibited lower scores, with a trend towards better visual learning performance across time. In summary, the FES patients were impaired in most of the parameters of the attention and learning tasks. Across time, modest improvements in reaction time and visual learning were displayed in the FES group. However, this group never caught up with the control group.

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Section: Discussionmentioning

confidence: 59%

“…Our results are particularly interesting due to the rapidly increasing use of the MCCB in studies of cognitive remediation in psychosis disorders Lystad et al, 2017). Cognitive remediation programs are usually strictly standardized, with the participants receiving the same therapeutic interventions at the same intervals.…”

Section: Discussionmentioning

confidence: 94%

Details of attention and learning change in first-episode schizophrenia

Mohn

Torgalsbøen

2018

Psychiatry Research

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“…Executive function should be examined in this group of patients, and intervention programs (as mentioned above) aiming at improving or preserving processing speed and executive function, should be administrated. Intervention programs that target cognitive dysfunction, such as cognitive remediation, has shown promising results in recent years (Deste et al, 2019;Lystad et al, 2017;Nuechterlein et al, 2011;Ventura et al, 2019;Wykes, 2008). Moreover, cognitive remediation in combination with rehabilitation, such as school and work training, enabled many patients to attain and maintain daily occupation (Lystad et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…Intervention programs that target cognitive dysfunction, such as cognitive remediation, has shown promising results in recent years (Deste et al, 2019;Lystad et al, 2017;Nuechterlein et al, 2011;Ventura et al, 2019;Wykes, 2008). Moreover, cognitive remediation in combination with rehabilitation, such as school and work training, enabled many patients to attain and maintain daily occupation (Lystad et al, 2017). For this vulnerable group of adolescents, it is especially important to provide cognitive remediation that may counteract a negative neurodevelopment and improve their prospects of achieving academic and professional success.…”

Section: Discussionmentioning

confidence: 99%

Gestational length affects neurocognition in early-onset schizophrenia

Teigset

Mohn

Rund

2016

Psychiatry Research

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Obstetric complications (OC) have been linked to an increased risk for schizophrenia in offspring, especially in early-onset schizophrenia (EOS). Extensive cognitive deficits occur in EOS, although no study has yet to investigate the relationship between OC and cognition in EOS. This study aims to examine the frequency of OC in EOS compared to controls, and also investigates the relationship between OC and neurocognitive dysfunction in the two groups. Nineteen EOS patients and 53 healthy controls were tested with the MATRICS Consensus Cognitive Battery (MCCB), and the cognitive measures were combined with OC data from the Norwegian Birth Registry. The results indicated no group differences in OC in EOS and healthy controls, but a shorter gestational length in the EOS group led to significant decreases in the overall neurocognitive composite score, and in processing speed. This suggests that the poorer neuropsychological performances commonly found in EOS may be partly attributable to the length of gestation. The worsened neurocognitive functioning did not appear among controls, so gestational length had a different impact on the two groups. Our findings indicated that a shorter gestational length did not increase the risk for developing EOS, but did significantly affect the cognitive difficulties in this group.

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“…Evidences suggest that significant improvement in social functioning occurs when cognitive training and other psychosocial rehabilitation programs administered together in addition to adoption of strategy coaching approach based on learning strategies. 66) Studies, where cognitive remediation was combined with other forms of rehabilitation and when it included strategy coaching, demonstrated significantly better functional outcomes.…”

Section: Evidence Base For Cognitive Remediationmentioning

confidence: 99%

Cognitive Deficits in Schizophrenia: Understanding the Biological Correlates and Remediation Strategies

Tripathi

Kar

Shukla

2018

Clin Psychopharmacol Neurosci

155

105

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Cognitive deficits are one of the core symptoms of schizophrenia that evolve during the course of schizophrenia, after being originated even before the onset of illness. Existing pharmacological and biological treatment modalities fall short to meet the needs to improve the cognitive symptoms; hence, various cognitive remediation strategies have been adopted to address these deficits. Research evidences suggest that cognitive remediation measures improve the functioning, limit disability bettering the quality of life. The functional outcomes of cognitive remediation in schizophrenia are resultant of neurobiological changes in specific brain areas. Recent years witnessed significant innovations in cognitive remediation strategies in schizophrenia. This comprehensive review highlights the biological correlates of cognitive deficits in schizophrenia and the remedial measures with evidence base.

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Cognitive remediation and occupational outcome in schizophrenia spectrum disorders: A 2 year follow-up study

Cited by 27 publications

References 56 publications

Details of attention and learning change in first-episode schizophrenia

Details of attention and learning change in first-episode schizophrenia

Gestational length affects neurocognition in early-onset schizophrenia

Cognitive Deficits in Schizophrenia: Understanding the Biological Correlates and Remediation Strategies

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