Cognitive Predictors of Everyday Functioning in Older Adults: Results From the ACTIVE Cognitive Intervention Trial

Gross, Alden L.; Rebok, George W.; Unverzagt, Frederick W.; Willis, Sherry L.; Brandt, Jason

doi:10.1093/geronb/gbr033

Cited by 83 publications

(84 citation statements)

References 55 publications

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“…Informant-SCC may be more sensitive to global changes (Jorm et al, 1996); therefore, while the RAVLT-Total measures initial auditory episodic learning of unstructured verbal information, it could also represent the participant’s general ability to learn new information, which, over time, could manifest as subtle yet observable deficits in daily functioning (Cargin, Collie, Masters, & Maruff, 2008; Gross, Rebok, Unverzagt, Willis, & Brandt, 2011). …”

Section: Discussionmentioning

confidence: 99%

Longitudinal Assessment of Self- and Informant-Subjective Cognitive Complaints in a Sample of Healthy Late-Middle Aged Adults Enriched with a Family History of Alzheimer’s Disease

Nicholas

Dowling

Racine

et al. 2017

J Int Neuropsychol Soc

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Objectives The purpose of this study was to investigate the longitudinal trajectory of self- and informant-subjective cognitive complaints (SCC), and to determine if SCC predict longitudinal changes in objective measures (OM) of cognitive function. Methods The study included healthy and cognitively normal late middle-aged adults enriched with a family history of AD who were evaluated at up to three visits over a 4-year period. At each visit (Visit 1–3), self- and informant-SCC and OM were evaluated. Linear mixed models were used to determine if the longitudinal rate of change of self- and informant-SCC were associated with demographic variables, depressive symptoms, family history (FH), and apolipoprotein epsilon 4 (APOE4) status. The same modeling approach was used to examine the effect of Visit 1 SCC on longitudinal cognitive change after controlling for the same variables. Results At Visit 1, more self-SCC were associated with fewer years of education and more depressive symptoms. SCC were also associated with poorer performance on cognitive measures, such that more self-SCC at Visit 1 were associated with poorer performance on memory and executive functioning measures at Visit 1, while more informant-SCC were associated with faster rate of longitudinal decline on a measure of episodic learning and memory. FH and APOE4 status were not associated with SCC. Discussion Self- and informant-SCC showed an association with OM, albeit over different time frames in our late middle-aged sample. Additional longitudinal follow-up will likely assist in further clarifying these relationships as our sample ages and more pronounced cognitive changes eventually emerge.

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Section: Discussionmentioning

confidence: 99%

Longitudinal Assessment of Self- and Informant-Subjective Cognitive Complaints in a Sample of Healthy Late-Middle Aged Adults Enriched with a Family History of Alzheimer’s Disease

Nicholas

Dowling

Racine

et al. 2017

J Int Neuropsychol Soc

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“…The Timed IADL was designed to assess rapid and efficient performance of tasks beneficial to daily life from the established IADL domains of telephone communication, financial abilities, nutrition, shopping, and medication usage (Owsley, Sloane, McGwin, & Ball, 2002). This measure has shown construct validity in comparison to other well-accepted measures of everyday function (Gross, Rebok, Unverzagt, Willis, & Brandt, 2011). Unfortunately, measures of everyday functional performance are somewhat limited.…”

Section: Discussionmentioning

confidence: 99%

A Comparison of Cognitive and Everyday Functional Performance Among Older Adults With and Without Hypertension

Hudak

Edwards

Athilingam

et al. 2013

Clinical Gerontologist

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Secondary data analyses examined the differences in cognitive and instrumental activities of daily living (IADL) performance among hypertensive individuals taking one of four classes of antihypertensive medications, hypertensive individuals not taking any antihypertensive medications, and normotensive individuals (N=770). After adjusting for covariates, significant group differences were evident on all measures (speed of processing, motor speed, reaction time, ps < .05) except memory and Timed IADL (ps > .05). Follow-up a priori planned comparisons compared hypertensive individuals not on medications to each of the four antihypertensive medication groups. Results indicated that only those on beta blockers (BB) were significantly slower in speed of processing (ps < .05). A priori planned comparisons also revealed that normotensive individuals had better cognitive performance on measures of processing speed, motor speed, and reaction time than hypertensive individuals regardless of antihypertensive medication use. Additionally, normotensive individuals performed significantly better on memory (Digit and Spatial Span) than individuals with hypertension on medications. No differences were found between groups on memory (Hopkins Verbal Learning Test) or Timed IADL performance. With regard to antihypertensive medications, the use of BBs was associated with slowed processing speed. These analyses provide empirical evidence that hypertension primarily impacts speed of processing, but not severe enough to affect IADL performance. Given the contribution of processing speed to memory and executive function performance, this is an important finding. Clinicians need to take into consideration the potential negative impact that BBs may have on cognition when determining the best treatment of hypertension among older adult patients.

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“…The association between cognitive impairment and dependence may be explained by the fact that the elderly with lower cognitive levels are less likely to be involved in treatment programs and control of chronic diseases, which may result in increased hospitalizations, causing major limitations (25) . Subjects with better cognitive status may be able to make choices and maintain lifestyle more favorable to health (28) . Hospitalization is an indicator of the occurrence of diseases that requires specialized care, which in itself results in a greater likelihood of functional incapacity.…”

Section: Discussionmentioning

confidence: 99%

Capacidade funcional e fatores associados em idosos: estudo populacional

et al. 2012

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Objective: To analyze the association of impaired functional capacity with health conditions and sociodemographic and behavioral factors among elderly residents in a community of northeastern Brazil. Methods: A cross-sectional population-based study, conducted with 316 elderly residents in Lafaiete Coutinho-BA. Functional capacity was evaluated by hierarchical scaling, by verifying association with health conditions and sociodemographic and behavioral factors by the technique of multinomial logistic regression. Results: The dependence for independent activities of daily living (IADL) was associated with the age group ≥ 80 years, use of two or more medications and cognitive impairment. Dependency in basic activities of daily living and IADL was associated with those in the age group ≥ 80 years, with a lack of participation in religious activities, hospitalization in the past 12 months, cognitive impairment and who were overweight. Conclusion: There was an association with impaired functional capacity, health conditions and sociodemographic factors among elderly residents in a community in northeastern Brazil. Keywords: Aged; Activities of daily living; Socioeconomic factors; Health of the elderly; Risk factors RESUMO Objetivo: Analisar a associação do comprometimento da capacidade funcional com condições de saúde e fatores sociodemográficos e comportamentais entre idosos residentes em comunidade do interior do Nordeste brasileiro. Métodos: Estudo transversal de base populacional realizado com 316 idosos residentes em Lafaiete Coutinho-BA. A capacidade funcional foi avaliada por escala hierárquica, verificando associação com condições de saúde e fatores sóciodemográficos e comportamentais pela técnica de regressão logística multinomial. Resultados: A dependência nas atividades independentes da vida diária (AIVD) foi associada ao grupo etário ≥ 80 anos, uso de dois ou mais medicamentos e comprometimento cognitivo. A dependência nas atividades básicas da vida diária e AIVD foi associada ao grupo etário ≥ 80 anos, falta de participação em atividades religiosas, hospitalização nos últimos 12 meses, comprometimento cognitivo e sobrepeso. Conclusão: Houve associação com comprometimento da capacidade funcional e condições de saúde e fatores sociodemográficos entre idosos residentes em comunidade no Nordeste brasileiro. Descritores: Idoso; Atividades cotidianas; Fatores socioeconômicos; Saúde do idoso; Fatores de risco RESUMEN Objetivo: Analizar la asociación del compromiso de la capacidad funcional con condiciones de salud y factores sociodemográficos y comportamentales entre ancianos residentes en una comunidad del interior del Noreste brasileño. Métodos: Estudio transversal de base poblacional realizado con 316 ancianos residentes en Lafaiete Coutinho-BA. La capacidad funcional fue evaluada por una escala jerárquica, verificando asociación con condiciones de salud y factores sociodemográficos y comportamentales por la técnica de regresión logística multinomial. Resultados: La dependencia en las atividades indep...

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Cognitive Predictors of Everyday Functioning in Older Adults: Results From the ACTIVE Cognitive Intervention Trial

Cited by 83 publications

References 55 publications

Longitudinal Assessment of Self- and Informant-Subjective Cognitive Complaints in a Sample of Healthy Late-Middle Aged Adults Enriched with a Family History of Alzheimer’s Disease

Longitudinal Assessment of Self- and Informant-Subjective Cognitive Complaints in a Sample of Healthy Late-Middle Aged Adults Enriched with a Family History of Alzheimer’s Disease

A Comparison of Cognitive and Everyday Functional Performance Among Older Adults With and Without Hypertension

Capacidade funcional e fatores associados em idosos: estudo populacional

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