Cognitive, linguistic and affective disturbances following a right superior cerebellar artery infarction: A case study

Mariën, Peter; Baillieux, Hanne; Smet, Hyo Jung De; Engelborghs, Sebastiaan; Wilssens, Ineke; Paquier, Philippe; Deyn, Peter Paul De

doi:10.1016/j.cortex.2007.12.010

Cited by 97 publications

(54 citation statements)

References 57 publications

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“…In the 1990s a possible role of the cerebellum in morphological, syntactic and lexical aspects of grammar was for the first time explored. These early studies indicated involvement of the cerebellum in the detection of deviations from predicted grammar rules such as subject-verb agreement or canonical word order [158, 160–162][159, 163–165]. Subsequent investigations substantiated and extended this view to a wider spectrum of cerebellar contribution including motor-independent comprehensive grammar analysis of sentence structure [158].…”

Section: Cerebellar Contributions To Grammar Processing (M Adamaszek)mentioning

confidence: 99%

“…Subsequent investigations substantiated and extended this view to a wider spectrum of cerebellar contribution including motor-independent comprehensive grammar analysis of sentence structure [158]. Recent experimental and neuroimaging data indicates that the cerebellum interfaces with the cerebral areas involved in grammar processing by means of integrating specific cerebral processing signals in a feed-forward manner [34, 159, 162, 166]. Although most studies have shown that the right cerebellar hemisphere is part of the cerebral network subserving grammar processing [86, 157, 160, 162, 167], a few studies indicate that the left or even both cerebellar hemispheres may be involved in grammar processing as well [29, 158, 161].…”

Section: Cerebellar Contributions To Grammar Processing (M Adamaszek)mentioning

confidence: 99%

“…Although most studies have shown that the right cerebellar hemisphere is part of the cerebral network subserving grammar processing [86, 157, 160, 162, 167], a few studies indicate that the left or even both cerebellar hemispheres may be involved in grammar processing as well [29, 158, 161]. Overall, recent findings indicate that the right cerebellum is embedded within a distinct grammar processing network, including the language dominant left prefrontal, temporal and parietal cortex and the basal ganglia [159, 163–165]. …”

Section: Cerebellar Contributions To Grammar Processing (M Adamaszek)mentioning

confidence: 99%

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Consensus Paper: Language and the Cerebellum: an Ongoing Enigma

Mariën

Ackermann

Adamaszek³

et al. 2013

Cerebellum

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In less than three decades, the concept “cerebellar neurocognition” has evolved from a mere afterthought to an entirely new and multifaceted area of neuroscientific research. A close interplay between three main strands of contemporary neuroscience induced a substantial modification of the traditional view of the cerebellum as a mere coordinator of autonomic and somatic motor functions. Indeed, the wealth of current evidence derived from detailed neuroanatomical investigations, functional neuroimaging studies with healthy subjects and patients and in-depth neuropsychological assessment of patients with cerebellar disorders shows that the cerebellum has a cardinal role to play in affective regulation, cognitive processing, and linguistic function. Although considerable progress has been made in models of cerebellar function, controversy remains regarding the exact role of the “linguistic cerebellum” in a broad variety of nonmotor language processes. This consensus paper brings together a range of different viewpoints and opinions regarding the contribution of the cerebellum to language function. Recent developments and insights in the nonmotor modulatory role of the cerebellum in language and some related disorders will be discussed. The role of the cerebellum in speech and language perception, in motor speech planning including apraxia of speech, in verbal working memory, in phonological and semantic verbal fluency, in syntax processing, in the dynamics of language production, in reading and in writing will be addressed. In addition, the functional topography of the linguistic cerebellum and the contribution of the deep nuclei to linguistic function will be briefly discussed. As such, a framework for debate and discussion will be offered in this consensus paper.

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Section: Cerebellar Contributions To Grammar Processing (M Adamaszek)mentioning

confidence: 99%

Section: Cerebellar Contributions To Grammar Processing (M Adamaszek)mentioning

confidence: 99%

Section: Cerebellar Contributions To Grammar Processing (M Adamaszek)mentioning

confidence: 99%

See 1 more Smart Citation

Consensus Paper: Language and the Cerebellum: an Ongoing Enigma

Mariën

Ackermann

Adamaszek³

et al. 2013

Cerebellum

Self Cite

319

351

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“…The vermis is involved in the processing of affective and fear-related responses such as anxiety (Reiman, 1997), grief (Gundel et al, 2003), and pain (Dimitrova et al, 2004). Many studies on cerebellar cognitive affective syndrome (CCAS) have ascribed the emotional disorders in these patients to vermal lesions (Marien et al, 2009;Schmahmann, 2004;Tavano and Borgatti, 2010). Neuroimaging studies have suggested that the cerebellum participates in affective circuits in which positive emotions are associated with the left cerebral hemisphere and negative emotions appear to be more aligned with the right hemisphere Silberman and Weingartner, 1986).…”

Section: Cerebellum and Amygdalamentioning

confidence: 99%

Resting-state functional connectivity of the vermal and hemispheric subregions of the cerebellum with both the cerebral cortical networks and subcortical structures

et al. 2012

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“…In the last two decades, an increasing number of studies have described cognitive impairments following damage to the cerebellum. Some reports have linked cerebellar lesions to difficulties in various cognitive domains, e.g., language and speech problems [4][5][6][7][8], visuo-spatial impairments [8][9][10], execu-tive dysfunctions and (verbal) working memory problems [11][12][13], learning disabilities [8,10,12], as well as impaired sequencing in cognitive domains [14,15]. In 1998, Schmahmann and Sherman tried to combine some of the described symptoms under the term cerebellar cognitive affective syndrome [16].…”

Section: Introductionmentioning

confidence: 99%

Long-term sequelae after acquired pediatric hemorrhagic cerebellar lesions

et al. 2010

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Purpose The aim of the present study was to assess cognitive, affective, and motor long-term sequelae after acquired focal pediatric cerebellar lesions. Methods Eight patients with a history of isolated acquired hemorrhagic cerebellar lesions before the age of 13 participated in this study. All participants underwent a neurologic examination, including the Zurich Neuromotor Assessment (ZNA) and the International Cooperative Ataxia Rating Scale (ICARS). Cognitive functions have been evaluated with a general cognitive assessment and an extensive neuropsychological battery. Furthermore, patients and parents filled in questionnaires about quality of life and possible behavioral or emotional problems. Results The results revealed that all patients exhibited motor problems (ZNA). Most participants had further restricted oculomotor movements (ICARS). Age at injury and the full scale IQ were significantly positively correlated (Pearson correlation 0.779; p=0.023). Conversely, no overall neuropsychological profile could be identified except for marginally reduced reaction times and susceptibility to interference. In addition, borderline results in semantic and phonemic word fluency tasks were apparent. A dysexecutive syndrome was diagnosed in one patient. However, verbal performance and reading abilities were non-pathologic in all participants. The patients reported having a good quality of life without major physical restrictions. Conclusions Emotional disturbances and the presence of a mild cerebellar cognitive affective syndrome (as frequently described in adult patients) could only be confirmed in adolescents with vermis lesions. Nevertheless, in laboratory conditions, neuropsychological impairments were present in all patients. Heterogeneity of age at injury and exact lesion site may have led to interpersonal differences in neuropsychological outcome.

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Cognitive, linguistic and affective disturbances following a right superior cerebellar artery infarction: A case study

Cited by 97 publications

References 57 publications

Consensus Paper: Language and the Cerebellum: an Ongoing Enigma

Consensus Paper: Language and the Cerebellum: an Ongoing Enigma

Resting-state functional connectivity of the vermal and hemispheric subregions of the cerebellum with both the cerebral cortical networks and subcortical structures

Long-term sequelae after acquired pediatric hemorrhagic cerebellar lesions

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