Resting-state functional connectivity of the vermal and hemispheric subregions of the cerebellum with both the cerebral cortical networks and subcortical structures

Li, Sang; Qin, Wen; Liu, Yong; Han, Wei; Zhang, Yunting; Jiang, Tianzi; Yu, Chunshui

doi:10.1016/j.neuroimage.2012.04.011

Cited by 218 publications

(206 citation statements)

References 122 publications

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“…Moreover, the cerebellum makes reciprocal connections with the prefrontal cortex [26]. Consistent with neuroanatomical findings, functional magnetic resonance imaging (fMRI) studies have demonstrated functional coherence between the cerebellum; the cerebral areas that mediate the processing of emotional information, such as the amygdala, hippocampus, hypothalamus, insula and anterior cingulate cortex; and cortical associative areas [27, [66][67][68].…”

Section: Emotional Unconscious and Conscious Circuitsmentioning

confidence: 92%

The Role of the Cerebellum in Unconscious and Conscious Processing of Emotions: A Review

et al. 2017

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Abstract:Studies from the past three decades have demonstrated that there is cerebellar involvement in the emotional domain. Emotional processing in humans requires both unconscious and conscious mechanisms. A significant amount of evidence indicates that the cerebellum is one of the cerebral structures that subserve emotional processing, although conflicting data has been reported on its function in unconscious and conscious mechanisms. This review discusses the available clinical, neuroimaging, and neurophysiological data on this issue. We also propose a model in which the cerebellum acts as a mediator between the internal state and external environment for the unconscious and conscious levels of emotional processing.

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Section: Emotional Unconscious and Conscious Circuitsmentioning

confidence: 92%

The Role of the Cerebellum in Unconscious and Conscious Processing of Emotions: A Review

et al. 2017

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“…Studies in rodents (Carbo-Gas et al, 2014a, Ikai et al, 1992, monkeys (Melchitzky and Lewis, 2000), and humans (Anderson et al, 2006) are indicative of dopaminergic synaptic components and transmission in the cerebellum across species. This evidence is accompanied by the fact that the cerebellar vermis has demonstrated to be linked to limbic and reward-related structures, such as amygdala (Sang et al, 2012;Yu et al, 2016), hippocampus (Sang et al, 2012), as well as ventral tegmental area (Rogers et al, 2011;Etkin et al, 2009;Kline et al, 2016;Kwon et al, 2014) and both dorsal (Tomasi and Volkow, 2011) ventral striatal zones (Cauda et al, 2011;Koehler et al, 2013). Accordingly, this part of the cerebellum could be able to integrate the incoming information from all these brain areas, which would encode the primary emotional and motivational aspects of the cue, to guide the response.…”

Section: The Cerebellum's Role: Craving or Prediction?mentioning

confidence: 99%

“…Notably, functional magnetic resonance imaging studies, including resting-state and task-related functional connectivity confirm cerebellar relationships between the cortical and subcortical areas involved in addiction, and specifically in craving. Concretely, co-activations and functional connections between cerebellum and cortical structures, such as dorsolateral prefrontal cortex (Habas et al, 2009;Leutgeb et al, 2016;Moulton et al, 2011;Sang et al, 2012), orbitofrontal cortex (Addis et al, 2016;Habas et al, 2009;Leutgeb et al, 2016), anterior cingulate cortex (Addis et al, 2016;Moulton et al, 2011;Sang et al, 2012;Zeng et al, 2012), insula (Addis et al, 2016;Habas et al, 2009;Moulton et al, 2011;Sang et al, 2012), and inferior frontal gyrus (Addis et , 2016;Moulton et al, 2011;Tomasi and Volkow, 2011) have been reported. Other subcortical structures such as amygdala (Leutgeb et al, 2016;Sang et al, 2012;Zeng et al, 2012), hippocampus (Onuki et al, 2015;Sang et al, 2012;Zeng et al, 2012), ventral tegmental area (Carnell et al, 2014;Etkin et al, 2009;Kline et al, 2016;Kwon et al, 2014), dorsal striatum (Moulton et al, 2011;Sang et al, 2012;Tomasi and Volkow, 2011), and ventral striatum (Cauda et al, 2011;Cservenka et al, 2014;Koehler et al, 2013) also have demonstrated to be connected to the cerebellum.…”

Section: Introductionmentioning

confidence: 99%

The cerebellum in drug craving

Moreno-Rius

Miquel

2017

Drug and Alcohol Dependence

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Craving has been considered one of the core features of addiction. It can be defined as the urge or conscious desire to use a drug elicited by the drug itself, drug-associated cues or stressors. Craving plays a major role in relapse, even after prolonged periods of abstinence, as well as in the maintenance of drug seeking in non-abstinent addicts. The circuitry of craving includes medial parts of the prefrontal cortex, ventral striatal zones, ventral tegmental area, ventral pallidum, and limbic regions. Interestingly, the cerebellum shows reciprocal loops with many of these areas. The cerebellum has been linked traditionally to motor functions but increasing evidence indicates that this part of the brain is also involved in functions related to cognition, prediction, learning, and memory. Moreover, the functional neuroimaging studies that have addressed the study of craving in humans repeatedly demonstrate cerebellar activation when craving is elicited by the presentation of drug-related cues. However, the role of cerebellar activity in these craving episodes remains unknown. Therefore, the main goal of this review is to provide a brief update on craving studies and the traditional neural basis of this phenomenon, and then discuss and propose a hypothesis for the function of the cerebellum in craving episodes.

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“…It may highly indicate the association between fusiform gyrus and cerebellar vermis. The atrophy of fusiform gyrus may be due to the cerebellar vermian deficits as functional connectivity between them has been reported (Sang et al., 2012). …”

Section: Discussionmentioning

confidence: 99%

Voxel‐based meta‐analysis of gray and white matter volume abnormalities in spinocerebellar ataxia type 2

et al. 2018

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ObjectiveTo identify the consistent findings from the whole‐brain voxel‐based morphometry (VBM) studies on spinocerebellar ataxia type 2 (SCA2).MethodsThe whole‐brain VBM studies comparing SCA2 patients and healthy controls (HCs) were systematically searched in PubMed, Embase databases from January 2000 to June 2017. The coordinates with significant differences in gray matter (GM) and white matter (WM) between SCA2 patients and HCs were extracted separately from each cluster. A meta‐analysis was performed using anisotropic effect size‐based signed differential mapping (AES‐SDM) software.ResultsA total of five studies with 65 SCA2 patients and 124 HCs were included in the GM meta‐analysis. Four of the five studies with 50 SCA2 patients and 109 HCs were included in the WM meta‐analysis. Significant and consistent GM volume reductions were detected in bilateral cerebellar hemispheres, cerebellar vermis, the right fusiform gyrus, the right parahippocampal gyrus, and the right lingual gyrus. The WM volume reductions were observed in bilateral cerebellar hemispheres, cerebellar vermis, middle cerebellar peduncles, pons, and bilateral cortico‐spinal projections. The findings of the study remained largely unchanged in jackknife sensitivity analysis.ConclusionsThe consistent findings from our meta‐analysis showed that GM volume reductions in SCA2 patients were not limited in cerebellum while significant WM volume reductions widely existed in cerebellum and pyramidal system. The findings provide morphological basis for further studies on SCA2.

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Resting-state functional connectivity of the vermal and hemispheric subregions of the cerebellum with both the cerebral cortical networks and subcortical structures

Cited by 218 publications

References 122 publications

The Role of the Cerebellum in Unconscious and Conscious Processing of Emotions: A Review

The Role of the Cerebellum in Unconscious and Conscious Processing of Emotions: A Review

The cerebellum in drug craving

Voxel‐based meta‐analysis of gray and white matter volume abnormalities in spinocerebellar ataxia type 2

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