Cognitive impairment in remitted patients with bipolar disorder

Чумаков, Егор; Петрова, Н. Н.; Лиманкин, О. В.; Ashenbrenner, Yulia

doi:10.17116/jnevro202112104112

Cited by 6 publications

(5 citation statements)

References 38 publications

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“…Cognitive impairment has been found to exist not only during the acute onset of bipolar disorder ( 14 , 15 ) but also during the remission phase of the disease ( 16 , 17 ). Bora et al ( 18 ) showed that deficits in neurocognitive development are already present in the early stages of bipolar disorder onset and that patients with bipolar disorder in the early stages of onset have significant neuropsychological deficits in IQ, verbal and deficits in IQ, verbal and visual memory, verbal fluency, and reasoning.…”

Section: Introductionmentioning

confidence: 99%

“…( 19 ), suggesting that some of the indicators of cognitive deficits in bipolar disorder are state markers of the patient that change as the condition changes and some are genetic markers that remain relatively stable across the stages of change. Since bipolar disorder is highly familial ( 17 , 18 ), it is entirely possible that some cognitive deficits exist in first-degree relatives of patients with bipolar disorder who do not have the condition ( 20 ). Therefore, exploring the clinical characteristics of patients with bipolar disorder and clarify the features of cognitive impairments is conducive to a more appropriate assessment the patients’ condition.…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics and cognitive function in bipolar disorder patients with different onset symptom

Wang,

Cao,

Cao

et al. 2023

Front. Psychiatry

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BackgroundIn recent years, studies on the clinical features and cognitive impairment of patients with different first-episode types of bipolar disorder have received increasing attention. The patients with bipolar disorder may present with different symptoms at first onset. The aim of this study is to assess the cognitive functions of a patient’s index episode of bipolar disorder, depression or mania, on risk factors of effecting on cognitive functions.MethodOne hundred sixty eight patients with bipolar disorder diagnosed for the first time were enrolled in the study. All patients were divided into two groups according to their index episode of bipolar disorder, either depression or mania. Seventy three patients of the cohort had an index episode mania and 95 patients had initial symptoms of depression. Demographic and clinical disease characteristic data of all enrolled patients were collected. Meanwhile, 75 healthy controls were included. Demographic data of controls were collected. The cognitive functions of all patients and controls were detected by continuous performance test (CPT), digital span test (DST) and Wisconsin card sorting test (WCST). The main cognitive functions data were compared among the mania group, depression group and control group. The relevant risk factors affecting cognitive function were analyzed.Results(1) Most patients with bipolar disorder had an index episode depression (56.55% vs. 43.45%). Compared with the depression group, the mania group had later age of onset [(24.01 ± 4.254) vs. (22.25 ± 6.472), t = 2. 122, p = 0.035]. The education level of patient groups was lower than control group (p < 0.001). (2) The healthy control group’s DST, WCST and CPT scores were better than the patient groups (All p < 0.05). The mania group’s DST (forward, reverse, sum), WCST (total responses, completed classifications, correct responses, incorrect responses, percentage of correct responses, completed the number of responses required for classification, the percentage of conceptualization level, the number of persistent responses, non-persistent errors), CPT (2 digit score, 3 digit score, 4 digit score) was better than the depression group (p < 0.05). (3) In mania group, correlation analysis showed that all CPT parameter, inverse digit span, and the sum of DST was negatively correlated with the education level (All p < 0.05). The CPT-4 digit score was negatively correlated with onset age (p < 0.05). In the WCST, the number of correct responses, the percentage of correct responses and the percentage of conceptualization level were positively correlated with the BRMS score (All p < 0.05). The number of false responses and persistent responses were negatively correlated with the BRMS score (All p < 0.05). The number of persistent errors and percentage of persistent errors was positively correlated with education years (All p < 0.05). In depression group, there was a positive correlation between inverse digit span and the education level (p < 0.05).ConclusionIn our study, there were cognitive impairments in attention, memory, and executive function of patients with different onset syndromes of bipolar disorder. Compared with the mania group, the degree of cognitive impairments in bipolar patients with the depressive episode was more severe. The risk factors affecting cognitive impairments included the age of onset, education level, number of hospitalizations and severity of illness.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical characteristics and cognitive function in bipolar disorder patients with different onset symptom

Wang,

Cao,

Cao

et al. 2023

Front. Psychiatry

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“…Given the new data on the frequency of residual [ 41 ] and subthreshold [ 22 , 43 , 44 ] symptoms in patients with BD in remission, the very notion of the limits of remission in BD is widely debated in the scientific literature. A growing body of evidence indicates that during remission, patients with BD often present subsyndromal mood symptoms, which are associated with poor psychosocial functioning, cognitive impairment, and reduced quality of life [ 45 , 46 , 47 , 48 ]. The validated IBI-BD index helps to assess the burden of negative factors on remission.…”

Section: Discussionmentioning

confidence: 99%

Individual Burden of Illness Index in Bipolar Disorder Remission: A Cross-Sectional Study

Chumakov,

Ashenbrenner,

Gvozdetskii

et al. 2024

Consortium Psychiatricum

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BACKGROUND: A population-based method for estimating disease burden is commonly used. Nevertheless, these measurements do not entirely capture the comprehensive burden of illness on an individual patient. To address the problem, the Individual Burden of Illness Index (IBI index) Index was created and validated, specifically for major depressive disorder. The IBI represents the overall influence of the condition, encompassing distress from symptom intensity, functional impairment, and the patient’s quality of life. AIM: The aim of the study was to approve and validate the IBI index for the integral assessment of disease burden in patients with bipolar disorder (BD) in remission. METHODS: The cross-sectional study was conducted in the outpatient psychiatric services in Saint Petersburg, Russia, from April through October 2020. Eighty-five patients aged 18 to 45 (mean age 36.6±5.7 years) with BD (type I — 75%, n=64; type II — 25%, n=21) in remission were examined. The study procedure included a structured clinical interview and the use of clinical scales: the World Health Organization’s Quality of Life Questionnaire, Hamilton Rating Scale for Depression (HDRS), Young Mania Rating Scale (YMRS), and Personal and the Social Performance Scale. RESULTS: The principal component analysis in accordance with the adjusted one showed that the burden of illness in patients with BD in remission is directly related to the severity of residual depressive symptoms, reflected in the HDRS score: as the HDRS score increases (0.27, p 0.001), residual mania (-0.14, p 0.001), social functioning (-0.06, p 0.001), and quality of life (-0.04, p 0.001) decrease. In contrast, when there are remaining residual mania symptoms, as indicated by the YMRS score, the result tends to be a lower burden, better social functioning, and enhanced quality of life. CONCLUSION: The study has demonstrated through statistical means a successful adaptation and validation of the previously calculated IBI index for patients with BD in remission. Residual affective symptoms were shown to have different impacts on the social functioning of patients with BD in remission, indicating the need for a timely assessment and targeted therapy of these symptoms in such patients.

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“…Cognitive dysfunction refers to the impairment of the above-mentioned cognitive functions, which seriously affects people's daily or social skills. Common cognitive dysfunction diseases include neurasthenia, mania, reactive psychosis (Mekori-Domachevsky et al, 2017;Anderson, 2019;Nemkova et al, 2019;Chumakov et al, 2021), etc. These diseases will seriously affect people's life safety and quality of life.…”

Section: Anti-cognitive Dysfunctionmentioning

confidence: 99%

Structure, function and mechanism of edible fungus polysaccharides in human beings chronic diseases

et al. 2023

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The feasibility of human nutritional supplementation is imperative. As a part of daily diet, edible fungus polysaccharides have a variety of health promoting effects, especially for the prevention of chronic diseases. Based on the extensive collection and collation of relevant research datas, the beneficial effects of edible fungus polysaccharides on various chronic diseases were analyzed, and the structure and functional mechanism of edible fungus polysaccharides with anti-chronic disease properties were summarized in this current review. Based on a comprehensive analysis of the current researchs on edible fungus polysaccharides, it was considered that edible fungus polysaccharides can be used as the material basis of anti-chronic disease drugs. In addition, the relevant contents can also provide some reference for the selection and development of anti-chronic disease drugs.

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Cognitive impairment in remitted patients with bipolar disorder

Cited by 6 publications

References 38 publications

Clinical characteristics and cognitive function in bipolar disorder patients with different onset symptom

Clinical characteristics and cognitive function in bipolar disorder patients with different onset symptom

Individual Burden of Illness Index in Bipolar Disorder Remission: A Cross-Sectional Study

Structure, function and mechanism of edible fungus polysaccharides in human beings chronic diseases

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