Cognitive impairment in euthymic major depressive disorder: a meta-analysis

Bora, Emre; Harrison, Ben J; Yücel, Murat; Pantelis, Christos

doi:10.1017/s0033291712002085

Cited by 446 publications

(385 citation statements)

References 55 publications

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“…With regard to demographic factors, our finding that cognitive impairment was less common in women compared with men in the MS group on some measures may reflect generally less severe disease course in women 32; a similar finding for women in the major depression group was unexpected in the light of a recent review, however 33. Impairment was also less common in older compared with younger participants within mania/BD, MS and PD groups.…”

Section: Discussionmentioning

confidence: 49%

The ‘cognitive footprint’ of psychiatric and neurological conditions: cross‐sectional study in the UK Biobank cohort

Cullen

Smith

Deary

et al. 2017

Acta Psychiatr Scand

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ObjectiveWe aimed to quantify the prevalence of cognitive impairment in adults with a history of mood disorder, schizophrenia, multiple sclerosis or Parkinson's disease, within a large general population cohort.MethodCross‐sectional study using UK Biobank data (n = 502 642). Psychiatric and neurological exposure status was ascertained via self‐reported diagnoses, hospital records and questionnaires. Impairment on reasoning, reaction time and memory tests was defined with reference to a single unexposed comparison group. Results were standardised for age and gender. Sensitivity analyses examined the influence of comorbidity, education, information sources and missing data.ResultsRelative to the unexposed group, cognitive impairment was least common in major depression (standardised prevalence ratios across tests = 1.00 [95% CI 0.98, 1.02] to 1.49 [95% CI 1.24, 1.79]) and most common in schizophrenia (1.89 [95% CI 1.47, 2.42] to 3.92 [95% CI 2.34, 6.57]). Prevalence in mania/bipolar was similar to that in multiple sclerosis and Parkinson's disease. Estimated population attributable prevalence of cognitive impairment was higher for major depression (256 per 100 000 [95% CI 130, 381]) than for all other disorders.ConclusionAlthough the relative prevalence of cognitive impairment was lowest in major depression, the population attributable prevalence was highest overall for this group.

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Section: Discussionmentioning

confidence: 49%

The ‘cognitive footprint’ of psychiatric and neurological conditions: cross‐sectional study in the UK Biobank cohort

Cullen

Smith

Deary

et al. 2017

Acta Psychiatr Scand

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“…Cognitive impairment is a common feature of mood disorders, persisting throughout remission or euthymia, 56 and contributing to functional disability (1)(2)(3)(4)(5)(6). Impairment is typically found on tests of attention, working 57 and episodic memory, processing speed and executive function, with standardised effect sizes in the 58 medium range compared to non-mood disordered controls (3)(4)(5)(6).…”

Section: Introduction 54 55mentioning

confidence: 99%

Cognitive function and lifetime features of depression and bipolar disorder in a large population sample: Cross-sectional study of 143,828 UK Biobank participants

et al. 2015

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There may be differences between this version and the published version. You are advised to consult the publisher's version if you wish to cite from it.http://eprints.gla.ac.uk/111591/ This study investigated differences in cognitive performance between middle-aged adults with and without a 28 lifetime history of mood disorder features, adjusting for a range of potential confounders. 29 30 Methods 31Cross-sectional analysis of baseline data from the UK Biobank cohort. Adults aged 40-69 (n=143,828) were 32 assessed using measures of reasoning, reaction time and memory. Self-reported data on lifetime features of 33 major depression and bipolar disorder were used to construct groups for comparison against controls. 34Regression models examined the association between mood disorder classification and cognitive 35 performance, adjusting for sociodemographic, lifestyle and clinical confounders.

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“…Studies provide evidence to suggest that depression is in fact associated with a global cognitive dysfunction affecting various cognitive domains. (Murrough et al 2011, Hasselbalch et al 2012, Lee et al 2012, Bora et al 2013, Wagner et al 2015. Cognitive deficits are related to the severity of the depressive episode and are more prevalent among patients with psychotic or melancholic features during their depressive episode (Bora et al 2013, Hasselbalch et al 2013.…”

Section: Cognitive Impairments In Depressionmentioning

confidence: 99%

“…(Murrough et al 2011, Hasselbalch et al 2012, Lee et al 2012, Bora et al 2013, Wagner et al 2015. Cognitive deficits are related to the severity of the depressive episode and are more prevalent among patients with psychotic or melancholic features during their depressive episode (Bora et al 2013, Hasselbalch et al 2013. Increasing evidence suggests that at least some of this cognitive dysfunction remains even after remission (Hasselbalch et al 2012, Bora et al 2013 Depression might also interfere with the motivational aspects of memory such that the patient puts less effort into necessary recall.…”

Section: Cognitive Impairments In Depressionmentioning

confidence: 99%

On electroconvulsive therapy in depression : Clinical, cognitive and neurobiological aspects

Nordanskog¹

2015

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Electroconvulsive therapy (ECT) is used worldwide to treat severe mental disorders. The most common mental disorder, and the third leading cause of disease burden in the world is depression. The clinical efficacy of ECT for severe depression is well-established. However, both the pathophysiology of depression and the mechanism of action of ECT remain elusive. The main aims of this thesis are to address the following issues: 1) the use and practice of ECT in Sweden has not been systematically evaluated since 1975, 2) cognitive side-effects (memory disturbances) are a major concern with ECT and 3) the mechanism of action of ECT remain elusive. The neurobiological aspects of ECT focus on two hypotheses. First, the recent years´ preclinical studies that have provided evidence that ECT induces hippocampal cell proliferation, including neurogenesis. Second, that enhanced functional inhibition of neuronal activity is a key feature. Current use and practice of ECT in Sweden (paper I) is based on data from the national quality register for ECT, the mandatory patient register of the National Board of Health and Welfare and a survey. Treated person rate (TPR) in Sweden 2013 was found to be 41 individuals / 100 000, and thus unchanged since the latest systematic investigation in Sweden 1975. In more than 70% of treatment series the indication was a depressive episode. The selection of patients for ECT and treatment technique in Sweden was similar to that in other western countries, but the consent procedure and the involvement of nurses and nursing assistants in the delivery of ECT differ. Data also shows that there is room for improvement in both the specificity of use and availability of ECT. The second study in this thesis is a longitudinal observational trial where 12 (paper II and III) and 14 (paper IV) patients with depression referred for ECT were investigated. Patients underwent a 3 T MRI structural scanning and DSC-MRI perfusion, a neuropsychological test battery and clinical ratings before ECT, within one to two weeks after ECT and after 6 and 12 months. In line with preclinical findings and the plasticity hypothesis of mechanism of action of ECT, the hippocampal volume increased after ECT in patients with depression. However, this increase was transient and returned to baseline levels within 6 months. No correlation was found between volumetric changes and clinical effect or cognitive outcome. Instead our results suggested an association to the number of treatments, without relation to the side of stimulation. A right-sided decrease in frontal blood flow distinguished remission from non-remission after ECT. There were significant impairments in verbal episodic memory and verbal fluency within one week after ending the ECT course, but these impairments were transient and no persistent cognitive impairments were seen during the follow-up. In summary, this thesis present the first update on the use and practice of ECT in Sweden in the last 40 years as well as a pioneering MRI-study on the hippocampal volume increase...

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Cognitive impairment in euthymic major depressive disorder: a meta-analysis

Cited by 446 publications

References 55 publications

The ‘cognitive footprint’ of psychiatric and neurological conditions: cross‐sectional study in the UK Biobank cohort

The ‘cognitive footprint’ of psychiatric and neurological conditions: cross‐sectional study in the UK Biobank cohort

Cognitive function and lifetime features of depression and bipolar disorder in a large population sample: Cross-sectional study of 143,828 UK Biobank participants

On electroconvulsive therapy in depression : Clinical, cognitive and neurobiological aspects

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