Cognitive Impairment: An Independent Predictor of Excess Mortality

Sachs, Greg A.; Carter, Ravan; Holtz, Laura R.; Smith, Frederick; Stump, Timothy E.; Tu, Wanzhu; Callahan, Christopher M.

doi:10.7326/0003-4819-155-5-201109060-00007

Cited by 168 publications

(138 citation statements)

References 30 publications

Supporting

Mentioning

127

Contrasting

Unclassified

Order By: Relevance

“…18,19 Among those who died within 1 year, the frequency of on-site CGAT consultations was lower than those who survived, possibly because the former were often in hospital and hence missed many scheduled CGAT clinics. Instead, they tended to see CVMOs more frequently and had more frequent fast-track clinic consultations.…”

Section: Discussionmentioning

confidence: 99%

Mortality and health services utilisation among older people with advanced cognitive impairment living in residential care homes

Luk¹,

Chan²,

Ng³

et al. 2013

Hong Kong Med J

View full text Add to dashboard Cite

Objectives To study the demography, clinical characteristics, service utilisation, mortality, and predictors of mortality in older residential care home residents with advanced cognitive impairment.Design Cohort longitudinal study. Setting ConclusionResidents of residential care homes for the elderly with advanced cognitive impairment were frail, exhibited multiple comorbidities and high mortality. They were frequent users of outpatient, emergency, and in-patient services. The development of end-of-life care services in residential care homes for the elderly is an important need for this group of elderly.

show abstract

Section: Discussionmentioning

confidence: 99%

Mortality and health services utilisation among older people with advanced cognitive impairment living in residential care homes

Luk¹,

Chan²,

Ng³

et al. 2013

Hong Kong Med J

View full text Add to dashboard Cite

show abstract

“…The number of deaths attributable to dementia in China went up from 1.6 million in 1990 to 2.3 million in 2016 2. Most recent epidemiological studies have reported an association between cognitive impairment and increased risk of all‐cause mortality, with both mild and moderate‐to‐severe cognitive impairment being predictors of all‐cause mortality in older adults 3, 4. However, to our knowledge, very few studies have examined this relationship in China 5, 6.…”

Section: Introductionmentioning

confidence: 97%

Cognitive Impairment and Risk of All‐Cause and Cardiovascular Disease Mortality Over 20‐Year Follow‐up: Results From the BLSA

Tang

et al. 2018

JAHA

View full text Add to dashboard Cite

BackgroundCognitive impairment may increase the risk of all‐cause and cardiovascular disease (CVD) mortality. This study examined the association between cognitive function and risk of all‐cause and CVD mortality among the elderly in Beijing, China.Methods and ResultsA total of 1996 participants aged ≥55 years at baseline were enrolled from the BLSA (Beijing Longitudinal Study of Aging). Cognitive function was assessed using the Mini‐Mental State Examination (MMSE), and participants were categorized as: <18, 18 to 23, 24 to 27, and 28 to 30. Cox proportional hazard models were used to estimate the association. Hazard ratio (HR) and 95% confidence interval (CI) were reported. During a 20‐year follow‐up, 1122 (56.21%) participants died, 478 (42.60%) of whom died of CVD. Compared with MMSE scores of 28 to 30, participants with MMSE scores of <18 were independently associated with all‐cause mortality (hazard ratio, 2.14; 95% confidence interval, 1.59–2.87; P<0.001) and CVD mortality (hazard ratio, 4.52; 95% confidence interval, 2.80–7.30, P<0.001). Each 5‐point decrease in MMSE score was associated with a 34% increased risk of all‐cause mortality and a 56% increased risk of CVD mortality. This relationship remained statistically significant after using the competing risk model to consider non‐CVD death as a competing risk event.ConclusionCognitive impairment measured by MMSE score was associated with elevated risk of all‐cause and CVD mortality among the elderly in Beijing, China.

show abstract

“…Mon raisonnement est le suivant: Il existe des données probantes convaincantes tirées de situations non chirurgicales qui montrent qu'une altération cognitive (AC) est associée à une mortalité précoce. [3][4][5] Il existe également une abondance de données probantes indiquant que l'AC est prévalente en préopératoire dans certaines populations chirurgicales.…”

unclassified

“…My reasoning is as follows: There is compelling evidence from non-surgical situations that cognitive impairment (CI) is associated with early mortality. [3][4][5] There is also ample evidence that CI is prevalent preoperatively in some surgical populations. [6][7][8][9] The association of CI with early mortality is unlikely to be erased by the process of undergoing anesthesia and surgery.…”

mentioning

confidence: 99%