Cognitive functions, electroencephalographic and diffusion tensor imaging changes in children with active idiopathic epilepsy

Yassine, I.; Eldeeb, Waleed M.; Gad, Khaled; Ashour, Yossri; Yassine, Inas A.; Hosny, Ahmed O.

doi:10.1016/j.yebeh.2018.04.024

Cited by 5 publications

(7 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Carlson HL et al found that bilateral thalamus cortical pathways in epilepsy patients were abnormal, and damage was associated with the disease course (Carlson HL, et al, 2014). DTI helps locate epileptic foci and recognizes cognitive changes between epilepsy patients and healthy individuals by analyzing these indices (A Yassine I, et al, 2018). Luis et al found that the FA value is decreased and the relevant cognitive score is related to the FA value.…”

Section: Difusion Tensor Imaging (Dti) and Difusion-weighted Imaging (Dwi)mentioning

confidence: 99%

Application value of molecular imaging technology in epilepsy

Rong

Zhang

Wang

et al. 2021

Ibrain

View full text Add to dashboard Cite

Epilepsy is a common neurological disease with various seizure types, complicated etiologies, and unclear mechanisms. Its diagnosis mainly relies on clinical history, but an electroencephalogram is also a crucial auxiliary examination. Recently, brain imaging technology has gained increasing attention in the diagnosis of epilepsy, and conventional magnetic resonance imaging can detect epileptic foci in some patients with epilepsy. However, the results of brain magnetic resonance imaging are normal in some patients. New molecular imaging has gradually developed in recent years and has been applied in the diagnosis of epilepsy, leading to enhanced lesion detection rates. However, the application of these technologies in epilepsy patients with negative brain magnetic resonance must be clarified. Thus, we reviewed the relevant literature and summarized the information to improve the understanding of the molecular imaging application value of epilepsy.

show abstract

Section: Difusion Tensor Imaging (Dti) and Difusion-weighted Imaging (Dwi)mentioning

confidence: 99%

Application value of molecular imaging technology in epilepsy

Rong

Zhang

Wang

et al. 2021

Ibrain

View full text Add to dashboard Cite

show abstract

“…It has a severe influence on children's growth and development. [8] The early standardized treatment can improve the prognosis in children with epilepsy. However, there is still a lack of effective treatment options at present.…”

Section: Discussionmentioning

confidence: 99%

Effects of sodium valproate combined with levetiracetam in treatment of children epilepsy and its influences on serum S-100 and high mobility group box-1

Hao

Chen

et al. 2020

DCC

View full text Add to dashboard Cite

Objective: To explore the effects of sodium valproate combined with levetiracetam in the treatment of children epilepsy, and its influences on serum S-100 and high mobility group box-1 (HMGB-1) in children with epilepsy.Methods: A total of 160 children who were diagnosed as epilepsy in Baogang Hospital of Inner Mongolia from July 2016 to October 2018 were selected as research objects. They were randomly divided into the study group (n = 80) and the control group (n = 80) by the random number table method, i.e., they were treated with sodium valproate combined with levetiracetam and sodium valproate alone, respectively. After 16 weeks of treatment, the effective rates of epileptic seizure treatment and the improvement of epileptiform discharge were evaluated, and chi-square test was used for statistical comparison. The related indicators, including serum tumor necrosis factor- (TNF-), hypersensitive C-reactive protein (hs-CRP), homocysteine (Hcy), haematocrit (HCT), erythrocyte sedimentation rate (ESR), serum S-100 and HMGB-1, were measured before and after treatment. Paired t-test was used for the comparison in the above indicators within a group before and after treatment; group t-test was used for the comparison between two groups. Chi-square test was used for the comparison in the rate of adverse reactions during treatment between two groups. The study was approved by Ethics Committee of Baogang Hospital (Approval No.: BG201606073), and all children’s guardians were required to sign informed consent forms for clinical study. There were no statistically significant differences between two groups in general clinical data (p > .05), such as sex constituent ratio, age, the course of disease, the frequency of epileptic seizure per year before treatment, the incidence of epileptiform discharge before treatment and the constituent ratio of types of epileptic seizure, etc.Results: 1) After treatment, the effective rates of epileptic seizure treatment and the improvement of epileptiform discharge in the study group were 92.5% (74/80) and 85.0% (68/80) respectively, which were both significantly higher than those in the control group [68.8% (55/80) and 58.8% (47/80)], and the differences were statistically significant (2 = 14.444, 13.635; p < .001). 2) In the study group, the levels of serum TNF-, hs-CRP and Hcy, as well as HCT and ESR after treatment were (53.1 ± 14.0) pg/ml, (5.0 ± 2.5) mg/L, (12.5 ± 3.1) μmol/L, (38.1 ± 5.1)% and (3.0 ± 0.5) mm/h respectively, which were all significantly lower than those [(107.9 ± 17.8) pg/ml, (10.1 ± 2.5) mg/L, (42.2 ± 5.8) μmol/L, (45.3 ± 4.5)% and (5.2 ± 0.6) mm/h] before treatment, and all the differences were statistically significant (t = 21.644, 12.902, 40.393, 9.468, 25.194; p < .001). In the control group, the levels of serum TNF-, hs-CRP and Hcy, as well as HCT and ESR after treatment were (60.6 ± 17.8) pg/ml, (8.2 ± 2.2) mg/L, (15.2 ± 3.1) μmol/L, (40.2 ± 3.4)% and (4.5 ± 0.6) mm/h respectively, which were all significantly lower than those [(112.4 ± 14.3) pg/ml, (9.3 ± 3.8) mg/L, (41.1 ± 2.8) μmol/L, (44.6 ± 5.5)% and (5.4 ± 0.8) mm/h] before treatment, and all the differences were statistically significant (t = 20.292, 2.241, 55.456, 3.320, 8.050; p < .05). After treatment, the above indicators in the study group were all significantly lower than those in the control group, and all the differences were statistically significant (t = 2.962, 8.595, 5.508, 3.064, 17.178; p < .05). 3) In the study group, the levels of serum S-100 and HMGB-1 after treatment were (0.65 ± 0.38) μg/L and (5.3 ± 2.4) μg/L respectively, which were significantly lower than those [(0.91 ± 0.32) μg/L and (8.1 ± 2.0) μg/L] before treatment, and the differences were statistically significant (t = 4.681, 8.020; p < .001). In the control group, the levels of serum S-100 and HMGB-1 after treatment were (0.78 ± 0.27) μg/L and (6.4 ± 2.2) μg/L respectively, which were significantly lower than those [(0.88 ± 0.25) μg/L and (7.9 ± 1.7) μg/L] before treatment, and the differences were statistically significant (t = 2.431, p = .016; t = 4.826, p < .001). After treatment, the levels of serum S-100 and HMGB-1 in the study group were significantly lower than those in the control group, and the differences were statistically significant (t = 2.495, p = .014; t = 2.840, p = .005). 4) There was no significant difference between two groups in the rate of adverse reactions, such as nausea, vomiting, poor appetite, dizziness, drowsiness, hepatic and renal injury during treatment (p > .05).Conclusions: The efficacy of sodium valproate combined with levetiracetam is obviously better than that of sodium valproate alone in the treatment of children epilepsy. The children patients’ serum S-100 and HMGB-1 are more significantly reduced, resulting in a lower rate of adverse reactions, which has a certain clinical value.

show abstract

“…This has been seen in temporal lobe epilepsy (TLE) and in FCD, where DTI-based VBM analysis assisted in accurate FCD subtype classification 8, 12 . In children diagnosed with active idiopathic epilepsy with and without cognitive impairment, DTI-based VBM and tractography analysis showed subtle microstructure and connectivity patterns that correlate to cognitive impairments (for example, verbal and memory) with relation to age of first seizure 11 . DKI and NODDI are even more sensitive than DTI 8 , but currently their use in pediatric epilepsy is limited.…”

Section: Precision In Structural Causes Of Epilepsy and Surgical Manamentioning

confidence: 99%

Precision in pediatric epilepsy

2019

View full text Add to dashboard Cite

Epilepsy in infants and children is one of the most common and devastating neurological disorders. In the past, we had a limited understanding of the causes of epilepsy in pediatric patients, so we treated pediatric epilepsy according to seizure type. Now with new tools and tests, we are entering the age of precision medicine in pediatric epilepsy. In this review, we use the new etiological classification system proposed by the International League Against Epilepsy to review the advances in the diagnosis of pediatric epilepsy, describe new tools to identify seizure foci for epilepsy surgery, and define treatable epilepsy syndromes.

show abstract

Cognitive functions, electroencephalographic and diffusion tensor imaging changes in children with active idiopathic epilepsy

Cited by 5 publications

References 59 publications

Application value of molecular imaging technology in epilepsy

Application value of molecular imaging technology in epilepsy

Effects of sodium valproate combined with levetiracetam in treatment of children epilepsy and its influences on serum S-100 and high mobility group box-1

Precision in pediatric epilepsy

Contact Info

Product

Resources

About