Application value of molecular imaging technology in epilepsy

Rong, Yan; Zhang, Haiqing; Wang, Jing; Zheng, Yongsu; Luo, Zhong; Zhang, Xia; Zhou, Xu

doi:10.1002/j.2769-2795.2021.tb00084.x

Cited by 4 publications

(1 citation statement)

References 106 publications

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“…[ 18 F] 28 has also been studied for measuring cortical thickness and neurons, − traumatic brain injury, − and disorders such as epilepsy, − as well as investigating the relationship between age and hearing, stroke, cerebral palsy, psychosis, aversive, awareness, , and healthy . However, despite the advantages of [ 18 F] 28 over [ 11 C] 28 , its widespread use has been hampered by low RCY or unavailability of precursors .…”

Section: F- and 11c-labeled Pet Tracers Based On Anestheticsmentioning

confidence: 99%

A Molecular Toolbox of Positron Emission Tomography Tracers for General Anesthesia Mechanism Research

Wang

Fan

et al. 2023

J. Med. Chem.

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With appropriate radiotracers, positron emission tomography (PET) allows direct or indirect monitoring of the spatial and temporal distribution of anesthetics, neurotransmitters, and biomarkers, making it an indispensable tool for studying the general anesthesia mechanism. In this Perspective, PET tracers that have been recruited in general anesthesia research are introduced in the following order: 1) 11 C/ 18 F-labeled anesthetics, i.e., PET tracers made from inhaled and intravenous anesthetics; 2) PET tracers targeting anesthesia-related receptors, e.g., neurotransmitters and voltage-gated ion channels; and 3) PET tracers for studying anesthesia-related neurophysiological effects and neurotoxicity. The radiosynthesis, pharmacodynamics, and pharmacokinetics of the above PET tracers are mainly discussed to provide a practical molecular toolbox for radiochemists, anesthesiologists, and those who are interested in general anesthesia.

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Section: F- and 11c-labeled Pet Tracers Based On Anestheticsmentioning

confidence: 99%

A Molecular Toolbox of Positron Emission Tomography Tracers for General Anesthesia Mechanism Research

Wang

Fan

et al. 2023

J. Med. Chem.

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Progesterone receptor membrane component 2 regulates the neuronal activity and participates in epileptic seizures in experimental mice

Xiao-yan

Yang

et al. 2023

Ibrain

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It was found the expression of progesterone receptor membrane component 2 (PGRMC2) in the histone of epileptic mice was lower than that of normal mice. In this study, we found by the immunofluorescence technique, PGRMC2 was expressed in both astrocytes and neurons of the mouse hippocampus. In addition, the seizure latency and seizure grade of mice in each group were observed after stereotactic injection of the PGRMC2 knockdown virus, PGRMC2 overexpression lentivirus, and related null virus into the hippocampus of mice. It was found that the seizure latency of mice in the PTZ + siPGRMC2 group was prolonged compared with the null virus group. The seizure latency was shortened in the PTZ + PGRMC2 group. The number of grade IV and above seizures in the PTZ + siPGRMC2 group was significantly reduced, while the number of grade IV and above seizures in the PTZ + PGRMC2 group was significantly increased. It was found that the nerve cells in the PTZ + siPGRMC2 group were still intact. In the PTZ + PGRMC2 group, the neural cells were damaged, the intercellular space was widened, and the number of cells was reduced. These findings support that PGRMC2 may be involved in epileptic seizures.

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Sheehan's syndrome misdiagnosed as encephalitis: A case report and literature review

Xiao-yan

Zheng

Tuo

et al. 2023

Ibrain

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A 48‐year‐old female patient was hospitalized for 5 days after a cold. Encephalitis was considered after preliminary history and routine examination, but the patient did not show significant improvement after antiviral treatment. At this time, magnetic resonance imaging indicated pituitary atrophy, and the patient's medical history was assessed. She had a history of postpartum bleeding and amenorrhea 15 years ago. The supplementary examination indicated hormonal abnormalities. These suggested that the patient may have had Sheehan's syndrome (SS). After hormone supplementation treatment for 10 days, her condition improved. This case suggested that in female patients with neuropsychiatric disorders with a history of previous postpartum hemorrhage, attention needs to be paid to screening for SS to improve the related diagnosis and treatment rate.

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Application value of molecular imaging technology in epilepsy

Cited by 4 publications

References 106 publications

A Molecular Toolbox of Positron Emission Tomography Tracers for General Anesthesia Mechanism Research

A Molecular Toolbox of Positron Emission Tomography Tracers for General Anesthesia Mechanism Research

Progesterone receptor membrane component 2 regulates the neuronal activity and participates in epileptic seizures in experimental mice

Sheehan's syndrome misdiagnosed as encephalitis: A case report and literature review

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