Cognitive functioning over 3 years in community dwelling older adults with chronic partial epilepsy

Griffith, H. Randall; Martin, Roy C.; Bambara, Jennifer K.; Faught, Edward; Vogtle, Laura; Marson, Daniel C.

doi:10.1016/j.eplepsyres.2007.01.002

Cited by 37 publications

(20 citation statements)

References 17 publications

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“…In the longitudinal studies reviewed here, duration emerged as a reliable predictor of cognitive decline in studies with a mean duration ranging from 18 years to 22 years. Of interest, Griffith et al (2007) did not find a significant duration effect despite a mean duration of 27 years. However, the older subjects included in this study also had a very late age of onset (mean of 37 years of age) which may have impacted the findings.…”

Section: Chronological Agementioning

confidence: 77%

“…The majority of studies (5/6) included subjects with a mean age of less than 50 years, and therefore predates the potential changes in cognition typically associated with normal aging. The lone exception is the study by Griffith et al (2007) which examined subjects with an average age at baseline of 65 years. Not surprisingly, the epilepsy group performed more poorly than controls on all cognitive measures at both baseline and retest.…”

Section: Chronological Agementioning

confidence: 99%

“…In contrast, 4/5 of the remaining studies included a younger aged cohort and found significant cognitive "decline" compared to controls. Griffith et al (2007) suggested a number of possible explanations for their unexpected findings (i.e., lack of progression) including the inclusion of a small sample size, floor effects, and variation due to duration of epilepsy. Nevertheless, these findings underscore the need for more longitudinal studies with older groups of subjects.…”

Section: Chronological Agementioning

confidence: 99%

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Cognitive Progression in Epilepsy

2007

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The issue of cognitive progression in people with epilepsy is of considerable interest and has important clinical and theoretical implications. In this paper, we review recent studies in both the adult and childhood epilepsy literature which have included a longitudinal test-retest design to examine this question. Several important methodological issues of this literature are highlighted and areas which require more investigation are identified.

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Section: Chronological Agementioning

confidence: 77%

Section: Chronological Agementioning

confidence: 99%

Section: Chronological Agementioning

confidence: 99%

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Cognitive Progression in Epilepsy

2007

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“…Some longitudinal studies in adult and mixed populations provide evidence for progressive intellectual decline in patients with (secondarily) generalized tonic–clonic seizures (Dodrill, 1986; Stefan and Pauli, 2002), but not for patients with focal seizures with or without loss of consciousness (Holmes et al, 1998; Stefan and Pauli, 2002; Griffith et al, 2007; Helmstädter and Elger, 2009). However, a problem in examining the impact of seizures is that most studies are based on self reporting.…”

Section: Structural Brain Damage Seizures or Ictal Slow Waves?mentioning

confidence: 99%

Is There a Relation between EEG-Slow Waves and Memory Dysfunction in Epilepsy? A Critical Appraisal

Höller

Trinka

2015

Front. Hum. Neurosci.

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Is there a relationship between peri-ictal slow waves, loss of consciousness, memory, and slow-wave sleep, in patients with different forms of epilepsy? We hypothesize that mechanisms, which result in peri-ictal slow-wave activity as detected by the electroencephalogram, could negatively affect memory processes. Slow waves (≤4 Hz) can be found in seizures with impairment of consciousness and also occur in focal seizures without impairment of consciousness but with inhibited access to memory functions. Peri-ictal slow waves are regarded as dysfunctional and are probably caused by mechanisms, which are essential to disturb the consolidation of memory entries in these patients. This is in strong contrast to physiological slow-wave activity during deep sleep, which is thought to group memory-consolidating fast oscillatory activity. In patients with epilepsy, slow waves may not only correlate with the peri-ictal clouding of consciousness, but could be the epiphenomenon of mechanisms, which interfere with normal brain function in a wider range. These mechanisms may have transient impacts on memory, such as temporary inhibition of memory systems, altered patterns of hippocampal–neocortical interactions during slow-wave sleep, or disturbed cross-frequency coupling of slow and fast oscillations. In addition, repeated tonic–clonic seizures over the years in uncontrolled chronic epilepsy may cause a progressive cognitive decline. This hypothesis can only be assessed in long-term prospective studies. These studies could disentangle the reversible short-term impacts of seizures, and the impacts of chronic uncontrolled seizures. Chronic uncontrolled seizures lead to irreversible memory impairment. By contrast, short-term impacts do not necessarily lead to a progressive cognitive decline but result in significantly impaired peri-ictal memory performance.

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“…According to some literary data, it is not possible to achieve complete recovery of cognitive functions even in case of stable remission [15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%