2016
DOI: 10.1212/wnl.0000000000002252
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Cognitive functioning of patients with a PRL-secreting pituitary adenoma

Abstract: This study demonstrated a significant relationship between PRL overproduction and worsening of cognitive processes, especially in the domains of memory and attention in hospitalized patients with pituitary adenomas. Greater hyperprolactinemia was associated with a larger decrease in cognitive performance. There was no effect of tumor size.

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Cited by 31 publications
(33 citation statements)
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“…In addition, serum hormone levels including PRL, E2, and LH, presented independent relationships with the mean GMV. These findings provide fundamental evidence for previous reports of cognitive dysfunction in a population with high PRL serum levels ( 4 , 21 , 22 ).…”
Section: Discussionsupporting
confidence: 86%
See 1 more Smart Citation
“…In addition, serum hormone levels including PRL, E2, and LH, presented independent relationships with the mean GMV. These findings provide fundamental evidence for previous reports of cognitive dysfunction in a population with high PRL serum levels ( 4 , 21 , 22 ).…”
Section: Discussionsupporting
confidence: 86%
“…In addition to these physical manifestations ( 2 , 3 ), dysfunctional hormones lead to cognitive impairments ( 4 , 5 ), yet, little is known about changes in brain structure in patients with prolactinomas. In the brain, hormone receptor expression has been identified in several regions and is generally located in the cell membrane or intracellularly in the nucleus, as well as in the glia, spines, and presynaptic terminals.…”
Section: Introductionmentioning
confidence: 99%
“…The cognitive dysfunction may be caused by both tumor mass compression of the related brain structures and effects of related hormonal imbalance that influence cognitive structures. However, up to now, the detailed mechanism of cognitive impairments is still unexplained [44][45] [46].…”
Section: Discussionmentioning
confidence: 99%
“…Hyperpituitarism can mainly cause cognitive deficits in functioning pituitary adenoma patients [46] Previous studies have suggested that frontal/parietal cortex and subcortical structures (e.g., thalamus) were related to attention selection and shifting [57] [58]. For example, recent studies specifically showed impairments in recognizing and regulating emotion in patients with temporal or frontal tumors [59].…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, apart from the physical damages, abnormal cognition appears commonly in pituitary adenoma patients. Substantial evidence has shown that pituitary patients frequently complain about problems in attention [5], working memory [6], executive function [7], depression [8], and emotion processing [9], which affect the quality of patients' life [10] [11].…”
Section: Introductionmentioning
confidence: 99%