Cognitive functioning of children with end-stage renal disease before and after successful transplantation

Rasbury, Wiley C.; Fennell, Robert S.; Morris, Mary

doi:10.1016/s0022-3476(83)80194-2

Cited by 43 publications

(19 citation statements)

References 7 publications

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“…In addition to the disease-specific physical challenges, adolescents are different from other ESRD subsets based on necessary cognitive maturation, academic and vocational achievement, and social maturation [23][24][25]. Chronic kidney failure has been implicated as a risk factor for cognitive deficits in children and adolescents [25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Trends in treatment and outcomes of survival of adolescents initiating end-stage renal disease care in the United States of America

et al. 2006

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This study characterizes treatment and outcome trends of adolescent patients initiating renal replacement therapy in the USA from 1978 to 2002. This is a retrospective analysis of data from the US Renal Data System (USRDS) of incident end-stage renal disease (ESRD) patients, ages 12 years through 19 years, initiating renal replacement therapy between 1978 and 2002. Survival analyses were conducted from either the first date of kidney failure or date of transplantation until death or 31 December 2002. The ESRD incidence per million adolescents increased from 17.6 in 1978 to 26.0 in 1990, with no change in incidence in the ensuing 12 years. Incidence was slightly higher among males than females and was twice as great in black than in white populations. The major cause of ESRD was glomerulonephritis followed by cystic/congenital diseases and focal segmental glomerulosclerosis (FSGS). Incidence increased with age, from 13.0 per million for children aged 13 years to 32.6 per million for 19 year olds. Three-quarters of all adolescent patients received at least one transplant, and one-fifth of patients received two or more transplants. Ten percent of incident adolescent patients received a preemptive transplant. The 10-year survival rate was lowest in the 1978-1982 incident cohort (77.6%) and improved to approximately 80% for later cohorts. Survival was better for younger adolescents, transplant recipients, preemptive transplant recipients, males, Caucasian, and Asian patients. The primary mode of renal replacement therapy is transplantation in most adolescent ESRD patients. The 80% 10-year survival rate for adolescent-onset ESRD is very good when compared with adult-onset ESRD. However, this represents a 30-fold increase in mortality compared to the general US adolescent population.

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Section: Discussionmentioning

confidence: 99%

Trends in treatment and outcomes of survival of adolescents initiating end-stage renal disease care in the United States of America

et al. 2006

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“…The effects of CKD on neurodevelopment and cognitive function of children remain largely unknown, but age of CKD onset (42,43), duration of kidney failure (44,45), hypertension (46), anemia (47)(48)(49)(50), and depression (51-53) have been associated with impairments in cognition and neurodevelopment. Furthermore, systematic assessment of nutritional status by measurement of growth parameters (height, weight, mid-upper arm circumference, pubertal development, and nutritional intake via 3 d diet history) and food frequency questionnaire will be collected to define further the influence of CKD on these parameters and the influence of these parameters on cognition and development.…”

Section: Discussionmentioning

confidence: 99%

Design and Methods of the Chronic Kidney Disease in Children (CKiD) Prospective Cohort Study

Furth

Cole

Moxey-Mims

et al. 2006

Clinical Journal of the American Society of Nephrology

362

326

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An estimated 650,000 Americans will have ESRD by 2010. Young adults with kidney failure often develop progressive chronic kidney disease (CKD) in childhood and adolescence. The Chronic Kidney Disease in Children (CKiD) prospective cohort study of 540 children aged 1 to 16 yr and have estimated GFR between 30 and 75 ml/min per 1.73 m 2 was established to identify novel risk factors for CKD progression; the impact of kidney function decline on growth, cognition, and behavior; and the evolution of cardiovascular disease risk factors. Annually, a physical examination documenting height, weight, Tanner stage, and standardized BP is conducted, and cognitive function, quality of life, nutritional, and behavioral questionnaires are completed by the parent or the child. Samples of serum, plasma, urine, hair, and fingernail clippings are stored in biosamples and genetics repositories. GFR is measured annually for 2 yr, then every other year using iohexol, HPLC creatinine, and cystatin C. Using age, gender, and serial measurements of Tanner stage, height, and creatinine, compared with iohexol GFR, a formula to estimate GFR that will improve on traditional pediatric GFR estimating equations when applied longitudinally is expected to be developed. Every other year, echocardiography and ambulatory BP monitoring will assess risk for cardiovascular disease. The primary outcome is the rate of decline of GFR. The CKiD study will be the largest North American multicenter study of pediatric CKD.

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“…Infants and young children who undergo complex paediatric therapies, such as open heart surgery (1-5), extracorporeal membrane oxygenation (ECMO) (6)(7)(8)(9) and solid organ transplants (10)(11)(12)(13)(14), are at risk for adverse long-term outcomes. The risk factors associated with adverse outcomes are multifactorial.…”

Section: Le Suivi Des Enfants Qui Reçoivent Des Traitements Effractifmentioning

confidence: 99%

“…A number of reports (1)(2)(3)(4)(5) on outcomes of open heart surgery in small infants have been published, and there has been a plea for centres treating congenital heart disease to collect and analyze outcome data, and to make these available to families with affected children and other institutions (5). There are also some data on the outcomes of infants and children treated with ECMO (6-9) and those with solid organ transplants (10)(11)(12)(13)(14), but many unanswered questions remain, and the same plea can be made to centres providing these therapies.…”

Section: Le Suivi Des Enfants Qui Reçoivent Des Traitements Effractifmentioning

confidence: 99%

Follow-up of children who received complex invasive therapies early in life

Sauvé

Robertson

2006

Paediatrics and Child Health

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Cognitive functioning of children with end-stage renal disease before and after successful transplantation

Cited by 43 publications

References 7 publications

Trends in treatment and outcomes of survival of adolescents initiating end-stage renal disease care in the United States of America

Trends in treatment and outcomes of survival of adolescents initiating end-stage renal disease care in the United States of America

Design and Methods of the Chronic Kidney Disease in Children (CKiD) Prospective Cohort Study

Follow-up of children who received complex invasive therapies early in life

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