Cognitive functioning in patients with familial bipolar I disorder and their unaffected relatives

Abstract

Impaired psychomotor performance speed and executive function may represent endophenotypes of BPD, reflecting possible underlying vulnerability to the disorder. Verbal memory impairments appear to be more related to the fully developed disorder.

Cognitive Impairment in Bipolar Disorder

“…Searching for neurocognitive endophenotypes in bipolar disorder, Finnish investigators administered a test battery to 32 familial bipolar I disorder patients, 40 of their unaffected first-degree relatives and 55 controls 52 . The relatives showed impairments in psychomotor performance speed and in executive function.…”

The Effect of Processing Speed on Cognitive Functioning in Patients with Familial Bipolar I Disorder and Their Unaffected Relatives

“…The role of slowed processing speed in verbal memory has been evidenced in other mental disorders including schizophrenia [9][10][11] and depression [12] and also in a twin sample of bipolar I disorder patients [13] . According to our previous studies of bipolar I disorder patients and their first-degree relatives, processing speed may be a potential endophenotype [14] for bipolar disorder [4,15] . In our previous study, we found that both the patients with familial bipolar I disorder and their unaffected first-degree relatives were significantly impaired compared to the controls in the task measuring processing speed (assessed with the digit symbol subtest of the Wechsler Adult Intelligence Scale-Revised, WAIS-R) [4] .…”

“…According to our previous studies of bipolar I disorder patients and their first-degree relatives, processing speed may be a potential endophenotype [14] for bipolar disorder [4,15] . In our previous study, we found that both the patients with familial bipolar I disorder and their unaffected first-degree relatives were significantly impaired compared to the controls in the task measuring processing speed (assessed with the digit symbol subtest of the Wechsler Adult Intelligence Scale-Revised, WAIS-R) [4] . In addition, the patients were more impaired in this function than their relatives.…”

“…Similar cognitive dysfunctions are also found in first-degree relatives of bipolar patients, although to a lesser degree [1][2][3] . In addition, bipolar patients show large deficits in processing speed [1,2] , which may be impaired also in relatives of familial bipolar I disorder [4,5] . Robinson et al [6] have suggested that further research is required to investigate whether the cognitive dysfunction associated with bipolar disorder arises from a certain deficit.…”

O uso da atenção como classificador diagnóstico em crianças e adolescentes com transtorno do humor bipolar e transtorno de déficit de atenção e hiperatividade

“…O prejuízo da atenção é bem documentado em adultos com THB (Clark et al, 2001;Cavanagh et al, 2002;Liu et al, 2002;Quraishi e Frangou, 2002); mesmo em pacientes eutímicos -com os sintomas do humor remitidos (Clark et al, 2002;Thompson et al, 2005); porém, estudos em familiares tiveram resultados contraditórios (Clark et al, 2005;Antila et al, 2007;Brotman et al, 2009). O prejuízo na atenção também foi descrito em pacientes e familiares com TDAH (Doyle et al, 2005a;Andreou et al, 2007).…”