Cognitive functioning in chronic fatigue syndrome: a meta-analysis

Cockshell, Susan J.; Mathias, Jane L.

doi:10.1017/s0033291709992054

Cited by 131 publications

(143 citation statements)

References 85 publications

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“…The levels of attention dysfunction found in this study appear to be consistent with deficits found in other studies (Busichio, et al, 2004;Capuron, et al, 2006;Cockshell & Mathias, 2010;DeLuca, et al, 1997). In addition, attention was the primary impairment in our sample.…”

Section: Discussionsupporting

confidence: 92%

“…Participants showed poor performance in motor functioning, consistent with some studies (Busichio et al, 2004;Claypoole et al, 2007) but not others (Cockshell & Mathias, 2010). These inconsistencies may be the result of instrument heterogeneity in the assessment of this function.…”

Section: Discussionsupporting

confidence: 83%

“…The selection of the battery used was based on previous studies (Busichio, et al, 2004;Claypoole, et al, 2007;Cockshell & Mathias, 2010), with the goal of assessing different cognitive domains. The instruments included were: Mental Control (WMS-III, Wechsler, 1997b), Paced Auditory Serial Addition Test (PASAT, Gronwall, 1977) , Digit Span (WAIS-III, Wechsler, 1997a), and Symbol Digit Modalities Test (SDMT, Smith, 1982); Stroop Test (Golden, 1978), Trail-Making Test (TMT, Reitan & Wofson, 1985), Verbal Fluency Test (FAS, Benton & Hamsher, 1978), and the Tower of London test (Shallice, 1982); Rey Auditory Verbal Learning test (RAVLT, Rey, 1964) andRey Complex Figure Test (RCFT(Rey, 1964) and Recognition Test (RT, (Meyers & Meyers, 1995); Grooved pegboard (Klove, 1963); and vocabulary subtest of the WAIS-III (Wechsler, 1997a).…”

Section: Neuropsychological Assessmentmentioning

confidence: 99%

“…Other findings suggest that attention could be the primary cognitive dysfunction in CFS Dickson, Toft, & O'Carroll, 2009), whereas other cognitive deficits, such as memory, could be secondary to this impairment. Overall, recent reviews conclude that the most common CFS related cognitive impairments are attention impairment (working memory and slowed reaction time) and reduced information processing speed (Cockshell & Mathias, 2010;Michiels The etiology of cognitive dysfunction in CFS is uncertain, and may have as its origin a wide spectrum of factors. One possible explanation is the effect of psychopathological factors (e.g.…”

Section: Introductionmentioning

confidence: 99%

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Neuropsychological Impairment in Female Patients with Chronic Fatigue Syndrome: A Preliminary Study

Santamarina-Pérez

Eiroá-Orosa

Rodríguez‐Urrutia

et al. 2013

Applied Neuropsychology: Adult

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This study examines neuropsychological impairments associated with Chronic Fatigue Syndrome (CFS) and explores their association with related clinical factors.Sixty-eight women with CFS were assessed with a neuropsychological battery. Raw scores were adjusted for age and gender and converted to T-scores according to normative data extracted from a local sample of 250 healthy subjects.Neuropsychological dysfunction was calculated using summary impairment indices (proportion of test scores outside normal limits-T-score<40-for each cognitive domain).Finally, a linear regression was calculated to identify predictors of cognitive deficit, including intrinsic factors (level of fatigue and length of illness) and extrinsic factors (emotional factors, age and education) of the disease. Approximately 50% of scores showed impairment in attention and motor functioning, and nearly 40% in speed information processing and executive functioning. Fatigue predicted attention and executive functioning impairment, and emotional factors predicted verbal memory dysfunction. According to our findings, cognitive dysfunction in CFS could be explained by pathophysiological processes of the disease. One implication of this would be the need to identify homogeneous subgroups of CFS patients by taking into account common factors which, in turn, would help to identify more specific cognitive profiles, which could then serve to implement appropriate therapeutic measures accordingly.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 83%

Section: Neuropsychological Assessmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Neuropsychological Impairment in Female Patients with Chronic Fatigue Syndrome: A Preliminary Study

Santamarina-Pérez

Eiroá-Orosa

Rodríguez‐Urrutia

et al. 2013

Applied Neuropsychology: Adult

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“…4 Patients who suffer from ME/CFS often report that they require increased mental effort, relative to that required before the onset of their illness, to complete everyday activities that require cognition. Experimentally, ME/CFS patients perform poorly, relative to controls, at tasks assessing attentional and working memory capacity [10][11][12][13]. Furthermore, a number of recent neuroimaging studies have shown increased brain activation in ME/CFS patients relative to control participants during cognitive tasks [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Characterising eye movement dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome

Badham

Hutchinson

2013

Graefes Arch Clin Exp Ophthalmol

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Background People who suffer from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) often report that their eye movements are sluggish and that they have difficulties tracking moving objects. However, descriptions of these visual problems are based solely on patients' self-reports of their subjective visual experiences and there is a distinct lack of empirical evidence to objectively verify their claims. This paper presents the first experimental research to objectively examine eye movements in those suffering from ME/CFS.Methods Patients were assessed for ME/CFS symptoms and were compared to age, gender and education matched controls for their ability to generate saccades and smooth pursuit eye movements.Results Patients and controls exhibited similar error rates and saccade latencies (response times) on prosaccade and antisaccade tasks. Patients showed relatively intact ability to accurately fixate the target (prosaccades) but were impaired when required to focus accurately in a specific position opposite the target (antisaccades). Patients were most markedly impaired when required to direct their gaze as closely as possible to a smoothly moving target (smooth pursuit).Conclusions It is hypothesised that the effects of ME/CFS can be overcome briefly for completion of saccades, but that continuous pursuit activity (accurately tracking a moving object) even for a short time period highlights dysfunctional eye movement behaviour in ME/CFS patients. Future smooth pursuit research may elucidate and improve diagnosis of ME/CFS.

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Sleep, Cognitive and Mood Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Wallis

Jackson

Ball

et al. 2017

The Handbook of Stress and Health

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Cognitive functioning in chronic fatigue syndrome: a meta-analysis

Abstract: Persons with CFS demonstrate moderate to large impairments in simple and complex information processing speed and in tasks requiring working memory over a sustained period of time.

Cited by 131 publications

References 85 publications

Neuropsychological Impairment in Female Patients with Chronic Fatigue Syndrome: A Preliminary Study

Neuropsychological Impairment in Female Patients with Chronic Fatigue Syndrome: A Preliminary Study

Characterising eye movement dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome

Sleep, Cognitive and Mood Symptoms in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

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